^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    FZD5 (Frizzled Class Receptor 5)

    i
    Other names: FZD5, Frizzled Class Receptor 5, C2orf31, HFZ5, Frizzled 5, Seven Transmembrane Spanning Receptor, Frizzled Family Receptor 5, DKFZP434E2135, Frizzled-5, Fz-5, FzE5, Seven-Transmembrane Receptor Frizzled-5, Chromosome 2 Open Reading Frame 31, Frizzled (Drosophila) Homolog 5, Frizzled Homolog 5 (Drosophila), Wnt Receptor, HFz5
    Associations

    News

    Trials
    5ms
    Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL. (PubMed, Elife)
    RSPO1 enhances Wnt signaling by specifically stabilizing FZD5/8...We further demonstrated that DVL proteins promote ligand-independent endocytosis of FZD but are dispensable for Wnt-induced FZD5/8 endocytosis and degradation. Our results reveal a novel negative regulatory mechanism of Wnt signaling at the receptor level and illuminate the mechanism by which RSPO-ZNRF3/RNF43 regulates Wnt signaling in human cells, which may provide new insights into regenerative medicine and cancer therapy.
    Journal
    |
    RNF43 (Ring Finger Protein 43) • FZD5 (Frizzled Class Receptor 5) • RSPO1 (R-Spondin 1) • ZNRF3 (Zinc And Ring Finger 3)
    5ms
    ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis. (PubMed, Free Radic Biol Med)
    In addition, ZNF831 inhibited tumour growth and progression through YTHDF1 mediated translational regulation of WNT pathway key genes WNT7B and FZD5. These results demonstrated that the feedback loop of ZNF831-YTHDF1-DNMT1/3a regulates cell growth, migration and invasion via WNT7B-FZD5-β-catenin axis, further providing a new idea for targeting epigenetic regulators of LC.
    Journal
    |
    DNMT3A (DNA methyltransferase 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • DNMT1 (DNA methyltransferase 1) • FZD5 (Frizzled Class Receptor 5) • WNT7B (Wnt Family Member 7B) • YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1)
    6ms
    Isovalerylspiramycin I Reprograms the Immunosuppressive and Temozolomide-Resistant Microenvironment by Inhibiting the Frizzled-5/Wnt/β-Catenin Pathway in Glioblastoma. (PubMed, Research (Wash D C))
    Consequently, the binding of transcription factors (T-cell factor 1/lymphoid enhancer factor 1) to promoters of CD274 and O6-methylguanine-DNA methyltransferase (MGMT) was impeded, thereby enhancing GBM cell susceptibility to TMZ. These findings elucidate the mechanisms underlying ISP-I's therapeutic efficacy in GBM and provide essential evidence for its clinical translation and combinatorial therapeutic strategies.
    Journal
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • CALR (Calreticulin) • FZD5 (Frizzled Class Receptor 5)
    |
    temozolomide
    8ms
    Fusion of spatiotemporal and network models to prioritize multiscale effects in single-cell perturbations. (PubMed, Brief Bioinform)
    In colitis, Perturb-STNet identified key genes (Csf1r, Col6a1, Lgr4, Myc, and Fzd5) and mediator pairs (Itga5-Flnc, Cd68-Csf1r, Csf1r-Cx3cl1, and Tnfrsf1b-Bmp1) involved in immune regulation, matrix remodeling, and epithelial repair, offering potential therapeutic targets. Overall, Perturb-STNet enables robust identification of spatiotemporal regulatory networks in single-cell perturbation data across diverse disease contexts.
    Journal
    |
    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD8 (cluster of differentiation 8) • CD79B (CD79b Molecule) • IL2RA (Interleukin 2 receptor, alpha) • CD5 (CD5 Molecule) • CD68 (CD68 Molecule) • CSF1R (Colony stimulating factor 1 receptor) • FOXP3 (Forkhead Box P3) • COL6A1 (Collagen Type VI Alpha 1 Chain) • CX3CL1 (C-X3-C Motif Chemokine Ligand 1) • KLRG1 (Killer Cell Lectin Like Receptor G1) • FLNC (Filamin C) • FZD5 (Frizzled Class Receptor 5) • ITGA5 (Integrin Subunit Alpha 5) • LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    9ms
    Internalization of extracellular double-stranded DNA as a potential marker of cancer stem cells in Epstein-Barr virus-induced B-cell lymphoma. (PubMed, Cancer Biomark)
    Transcriptomic analysis revealed that in TAMRA + cells, the synthesis of mitochondrial genes, as well as caspases and some apoptosis inhibitors, is reduced. TAMRA + cells possess clonogenic properties, increased level of synthesis of mRNA for key genes associated with self-renewal and poorly differentiated state maintenance.ConclusionsInternalization of the TAMRA-DNA probe is the marker of B-lymphoma cancer stem cells and can be used to detect tumor stem cells and develop new approaches to targeted treatment of B-lymphoma.
    Journal
    |
    MMP2 (Matrix metallopeptidase 2) • SOX2 • TCF3 (Transcription Factor 3) • POU5F1 (POU Class 5 Homeobox 1) • NANOG (Nanog Homeobox) • CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) • FZD5 (Frizzled Class Receptor 5) • FZD7 (Frizzled Class Receptor 7)
    10ms
    Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors. (PubMed, Cell Commun Signal)
    Reduction of ER stress by treatment of cells with the chemical chaperone tauroursodeoxycholic acid or by expression of the chaperone protein BiP resulted in restoration of receptor maturation and signaling. We show a previously unappreciated pathological effect of ER stress; impaired cellular communication due to altered receptor processing. Our findings have implications for disease mechanisms related to ER stress and are particularly important when receptor-based pharmacological approaches are used for treatment.
    Journal
    |
    FGFR3 (Fibroblast growth factor receptor 3) • FGFR1 (Fibroblast growth factor receptor 1) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • FZD5 (Frizzled Class Receptor 5)
    1year
    Cancer-associated fibroblasts promote growth and dissemination of esophageal squamous cell carcinoma cells by secreting WNT family member 5A. (PubMed, Mol Cell Biochem)
    The rW treatment also enhanced tumorigenesis and metastasis of xenograft tumors in nude mice, with these effects diminished by AW or AF treatment. This study suggests that CAFs promote growth and dissemination of ESCC cell primarily through the secretion of WNT5A.
    Journal
    |
    FZD5 (Frizzled Class Receptor 5)
    1year
    MAFG-DT promotes prostate cancer bone metastasis through activation of the Wnt/β-catenin pathway. (PubMed, Front Oncol)
    Additionally, the transcription factor MAFG was found to transcriptionally activate MAFG-DT in PCa. This study confirms the oncogenic role of MAFG/MAFG-DT/miR-24-3p/Wnt/β-catenin in PCa, which suggests that MAFG-DT could serve as a potential therapeutic target for PCa.
    Journal
    |
    FZD5 (Frizzled Class Receptor 5) • MILIP (MYC Inducible LncRNA Inactivating P53)
    1year
    Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. (PubMed, Cancer Immunol Res)
    In murine tumor models, both genetic and pharmaceutical suppression of WNT7A led to increased MHC-I levels on tumor cells, and consequently enhanced the infiltration and functionality of CD8+ T cells, which bolstered antitumor immunity and improved the effectiveness of immune checkpoint blockade therapy. These findings have elucidated the intrinsic mechanisms of WNT7A-induced immune suppression, suggesting that therapeutic interventions targeting WNT7A hold promise for enhancing the efficacy of immunotherapy.
    Journal • Checkpoint inhibition • IO biomarker • Checkpoint block
    |
    CD8 (cluster of differentiation 8) • WNT7A (Wnt Family Member 7A) • FZD5 (Frizzled Class Receptor 5)
    |
    CD8 expression
    over1year
    Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL. (PubMed, bioRxiv)
    RSPO1 enhances Wnt signaling by specifically stabilizing FZD5/8...We further demonstrated that DVL proteins promote ligand-independent endocytosis of FZD but are dispensable for Wnt-induced FZD5/8 endocytosis and degradation. Our results reveal a novel negative regulatory mechanism of Wnt signaling at the receptor level and illuminate the mechanism by which RSPO-ZNRF3/RNF43 regulates Wnt signaling, which may provide new insights into regenerative medicine and cancer therapy.
    Journal
    |
    RNF43 (Ring Finger Protein 43) • FZD5 (Frizzled Class Receptor 5) • RSPO1 (R-Spondin 1) • ZNRF3 (Zinc And Ring Finger 3)
    over1year
    E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors. (PubMed, Life Sci Alliance)
    In accordance, tissue-specific expression patterns of FZD homologues correlate with the incidence of RNF43 or ZNRF3 cancer mutations in those tissues. Consequently, our data point to druggable vulnerabilities of specific FZD receptors in RNF43- or ZNRF3-mutant human cancers.
    Journal
    |
    RNF43 (Ring Finger Protein 43) • FZD5 (Frizzled Class Receptor 5) • FZD6 (Frizzled Class Receptor 6) • FZD7 (Frizzled Class Receptor 7) • ZNRF3 (Zinc And Ring Finger 3)
    almost2years
    circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis. (PubMed, J Biochem Mol Toxicol)
    In summary, circ_0000592 promoted the progress of ESCC by counteracting the inhibitory impact on FZD5 through its interaction with miR-155-5p. Together, our findings highlighted circ_0000592 as a prospective therapeutic target for ESCC.
    Journal
    |
    MIR155 (MicroRNA 155) • FZD5 (Frizzled Class Receptor 5)