FUS (FUS RNA Binding Protein)

SEO exerts antidepressant-like effects in BCRD by modulating hippocampus-centered metabolic and functional networks. Eugenol and 2-phenylethanol were identified as key brain-entry components to function through metabolic pathways. ALOX15 inhibition and CAII improvement were proven to be the main molecular mechanisms. These findings provide mechanistic insights and identify SEO as a promising plant-derived therapeutic candidate for managing cancer-related depression.

No specific clustering was seen among different fusion types or tumor grade. Our findings support that BSS represents a unique and molecularly distinct sinonasal sarcoma with a characteristic DNA methylation signature, independent of gene fusion partners or histologic progression, providing a valuable tool for the classification of challenging cases.

P2/3, N=437, Active, not recruiting, Children's Oncology Group | Trial completion date: Jul 2032 --> Dec 2027 | Trial primary completion date: Jul 2032 --> Dec 2027

The influence of pulling force on co-condensation displays a step-like pattern, and increasing force can reduce superhelical levels. These findings elucidate the mechanisms underlying the response of FUS-DNA co-condensation to mechanical stress and provide new insights into their regulatory roles in biological processes.

These results establish that MB-FUS enables spatially-targeted AAV delivery with quantifiable enhancement of both acute vector biodistribution and downstream transgene expression. The integration of radiolabeled AAV with PET imaging provides a non-invasive methodology for real-time assessment of vector delivery and optimization of treatment protocol for brain cancer gene therapy.

The t(16;21)(p11;q22) FUS::ERG fusion gene is rare in pediatric AML and associated with poor prognosis. Allo-HSCT may mitigate the adverse prognostic impact of the FUS::ERG fusion gene and contribute to prolonged survival.

Distinct pathogenic NLS mutations of FUS differentially regulate cellular stress responses through different mechanisms, contributing to ALS initiation and progression. Among these, FUSP525L promotes the formation of larger stress granules, whereas FUSR514S more readily activates the cellular ISR.

These findings suggest that in early prostate cancer, FUS represses AR activity and tumour progression, leading to its down-regulation. In contrast, increased FUS expression in advanced disease appears to be linked to a loss of AR regulatory control.

The structure is unable to incorporate wild-type TAF15, despite the individual being heterozygous, suggesting that this variant drives TAF15 filament assembly. This study provides structural and genetic evidence that TAF15 amyloid filaments underlie the diverse group of neurodegenerative diseases currently termed FTLD-FET, which we therefore rename FTLD-TAF15.

Our work provides new insights into factors that uncouple FUS and TDP-43 aggregation from toxicity and support a rather protective role for FUS and TDP-43 aggregates in promoting longevity.

The patient succumbed to the disease 4 months after surgery. RMS with FUS-TFCP2 fusion is rare, highly aggressive and associated with a poor prognosis.

These findings confirm the diagnosis of MELTVR. Although the biological behaviors of MELTVR remain incompletely understood, recognition of its characteristic morphologic and immunophenotypic profiles will aid in distinguishing it from potential histological mimics better.