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    BIOMARKER:

    FUS-ERG fusion

    i
    Other names: ERG, ETS Transcription Factor ERG, Transcriptional Regulator ERG (Transforming Protein ERG), V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog, V-Ets Avian Erythroblastosis Virus E26 Oncogene Related, V-Ets Erythroblastosis Virus E26 Oncogene Like, Transcriptional Regulator ERG, Erythroblast Transformation-Specific Transcription Factor ERG Variant 10, V-Ets Erythroblastosis Virus E26 Oncogene Homolog, TMPRSS2-ERG Prostate Cancer Specific, ERG ETS Transcription Factor, Transforming Protein
    Entrez ID:
    2078; 2521
    Related biomarkers:
    Expression
    Fusion
    12ms
    Comparison of characteristics and prognostic impact of FUS-ERG and AML1-MTG16 fusion genes in adult AML patients: A retrospective study from 1988 to 2022 with a medical database. (ASCO 2023)
    The retrospective study summarized the clinical characteristics of AML1-MTG16 and FUS-ERG, identifying their distinctions on multiple aspects such as prior disease, recurrence rate, response to chemotherapy and cytogenetics. AML1-MTG16 exhibited extremely bad prognosis like FUS-ERG in adult population, which varied from the results in pediatric cohort. Several factors including age, CR after induction chemotherapy, HSCT, trisomy and monosomy were relevant to the prognosis of FUS-ERG.
    Retrospective data
    |
    RUNX1 (RUNX Family Transcription Factor 1) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • ERG (ETS Transcription Factor ERG) • FUS (FUS RNA Binding Protein) • CBFA2T3 (CBFA2/RUNX1 Partner Transcriptional Co-Repressor 3)
    |
    ER positive • FUS-ERG fusion
    over1year
    TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review. (PubMed, Ann Hematol)
    The relevant mechanism includes new mutation, jumping translocation, different transcripts, and so on. The mechanism still acquaints scarcely, which requires further study.
    Retrospective data • Review • Journal
    |
    BRAF (B-raf proto-oncogene) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • SMAD4 (SMAD family member 4) • BCOR (BCL6 Corepressor) • CD123 (Interleukin 3 Receptor Subunit Alpha) • ERG (ETS Transcription Factor ERG) • JAK3 (Janus Kinase 3) • NCAM1 (Neural cell adhesion molecule 1) • FUS (FUS RNA Binding Protein) • GATA2 (GATA Binding Protein 2)
    |
    BRAF mutation • RUNX1 mutation • SMAD4 mutation • JAK3 mutation • FUS-ERG fusion