^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    FUBP1 (Far Upstream Element Binding Protein 1)

    i
    Other names: FUBP1, Far Upstream Element Binding Protein 1, FBP, Far Upstream Element (FUSE) Binding Protein 1, Far Upstream Element-Binding Protein 1, FUSE Binding Protein 1, DNA Helicase V, HDH V, FUBP, Epididymis Secretory Sperm Binding Protein, FUSE-Binding Protein 1
    Associations

    News

    Trials
    27d
    FIR/PUF60: Multifunctional Molecule Through RNA Splicing for Revealing the Novel Disease Mechanism and Effective Individualized Therapies. (PubMed, Int J Mol Sci)
    Our objective is to develop efficient methods for identifying biomarkers for disease diagnosis and therapeutic targets. In the field of cancer treatment, therapeutic drugs targeting intracellular signaling have proven effective.
    Review • Journal
    |
    FUBP1 (Far Upstream Element Binding Protein 1)
    2ms
    Ovarian GLI1 fusion tumors Mimicking Sex Cord-Stromal Tumors: Clinicopathological and Molecular Characterization of a Five-Case Series. (PubMed, Hum Pathol)
    Transcriptomic analysis revealed no significant correlation between ovarian GLI1 fusion tumors and sclerosing stromal tumors. These findings underscore the necessity of molecular testing for GLI1 rearrangements in SCST-like ovarian tumors to ensure accurate diagnosis and appropriate clinical management.
    Journal
    |
    GLI1 (GLI Family Zinc Finger 1) • MME (Membrane Metalloendopeptidase) • FOXL2 (Forkhead Box L2) • FUBP1 (Far Upstream Element Binding Protein 1)
    4ms
    Quantitative Reactivity Profiling of Functional Arginine Residues in Human Cancer Cell Line Proteomes. (PubMed, Angew Chem Int Ed Engl)
    We also introduced ArGO-LDHA-1, a covalent inhibitor targeting LDHA's hyperreactive arginine residues, showing potential to enhance chemotherapy efficacy. This work highlights the biological significance of arginine residues and provides a platform for large-scale profiling of arginine reactivity.
    Preclinical • Journal
    |
    LDHA (Lactate dehydrogenase A) • LDHB (L-lactate dehydrogenase B chain) • CKB (Creatine Kinase B) • FUBP1 (Far Upstream Element Binding Protein 1)
    5ms
    PTBP1 Reduces KLF9 mRNA Stability and Upregulates FUBP1 to Promote Colorectal Cancer Stemness and Cisplatin Resistance. (PubMed, FASEB J)
    PTBP1 reduced KLF9 mRNA stabilization by binding to KLF9 mRNA, which promoted CRC cell stemness and DDP chemoresistance. PTBP1 reduced the stability of KLF9 mRNA, thereby relieving the transcriptional inhibition of FUBP1 by KLF9, leading to the development of stemness and DDP chemoresistance in CRC cells.
    Journal
    |
    PTBP1 (Polypyrimidine Tract Binding Protein 1) • FUBP1 (Far Upstream Element Binding Protein 1)
    |
    cisplatin
    6ms
    Expression of FUBP1 in gastrointestinal stromal tumors and its regulation of cell proliferation, migration, and invasion. (PubMed, Pathobiology)
    FUBP1 is upregulated in GISTs and facilitates the invasion, migration, and proliferation of GIST cells. This provides a new perspective for understanding the pathogenesis of GIST and lays a foundation for developing potential therapeutic strategies targeting FUBP1.
    Journal
    |
    FUBP1 (Far Upstream Element Binding Protein 1)
    7ms
    Epigenetic Activation of CCDC183-AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis. (PubMed, Adv Sci (Weinh))
    Significantly, the administration of the selective FUBP1 inhibitor, FUBP1-IN-1, is shown to effectively suppress CCDC183-AS1-induced PCa BM. These results shed light on the involvement of CCDC183-AS1 in enhancing osteoclastogenesis and the underlying mechanism in facilitating PCa BM, offering a potential avenue for therapeutic interventions.
    Journal
    |
    KDM5C (Lysine Demethylase 5C) • TNFSF14 (TNF Superfamily Member 14) • FUBP1 (Far Upstream Element Binding Protein 1)
    8ms
    circACTN4 promotes breast cancer cell cycle progression and oncogenesis via c-MYC induced histone H4 acetylation. (PubMed, Oncol Res)
    Taken together, our findings reveal for the first time a new mechanism by which circACTN4 could promote oncogenesis and the development of BC by increasing the AcH4 of MYC target genes via TIP60. Therefore, circACTN4 could be a novel target for BC diagnosis and remedy.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • ACTN4 (Actinin Alpha 4) • FUBP1 (Far Upstream Element Binding Protein 1)
    8ms
    Regulatory RNA network mediated by FUBP1 drives the proliferation and invasion of triple-negative breast cancer cells. (PubMed, Med Oncol)
    Additionally, lnc-CCNB1IP1-1-1 knockdown reduced PARP2 expression. Thus, FUBP1 knockdown activates lnc-CCNB1IP1-1-1 to modulate TNBC progression, revealing new insights into FUBP1's role in TNBC RNA networks.
    Journal • PARP Biomarker
    |
    PARP2 (Poly(ADP-Ribose) Polymerase 2) • FUBP1 (Far Upstream Element Binding Protein 1)
    8ms
    Disruption of Microhomology-mediated End-joining in Ewing Sarcoma. (PubMed, bioRxiv)
    - Ewing sarcoma tumors have a deficiency in POLθ expression and a corresponding loss of MMEJ activity - EWSR1 is a splicing factor that interacts with other splicing factors such as FUBP1 and KHSRP/FUBP2 to accurately splice the POLQ mRNA. - The EWS-FLI1 fusion oncoprotein, or loss of EWSR1, causes a splicing defect, leading to exon25 skipping of the POLQ pre-mRNA and loss of POLθ expression - The MMEJ deficiency of EwS cells results in cellular sensitivity to inhibitors of Homologous Recombination or Non-Homologous End-Joining - Exon 25 skipping of POLQ mRNA is a predictive biomarker for HR inhibitors in human cancers.
    Journal
    |
    EWSR1 (EWS RNA Binding Protein 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUBP1 (Far Upstream Element Binding Protein 1)
    8ms
    Identification of Proteins Associated with Ovarian Cancer Chemotherapy Resistance Using MALDI-MSI. (PubMed, Int J Mol Sci)
    Furthermore, both COL12A1 and PLEC mRNA and protein levels were significantly associated with chemotherapy resistance. In summary, using MALDI-MSI, we have identified proteins, including COL12A1 and PLEC, associated with chemotherapy resistance to be further evaluated as HGSOC biomarkers and/or therapeutic targets.
    Journal
    |
    COL12A1 (Collagen Type XII Alpha 1 Chain) • SLC4A1 (Solute Carrier Family 4 Member 1) • FUBP1 (Far Upstream Element Binding Protein 1)
    9ms
    Genomic and clinical insights into ovarian cancer: subtype-specific alterations and predictors of metastasis and relapse. (PubMed, Discov Oncol)
    This study reveals subtype-specific and metastasis-related genomic alterations in ovarian cancer and identifies potential relapse-associated mutations in HGSC. While exploring, these findings support further investigation into individualized risk stratification and biomarker-driven therapeutic strategies.
    Journal • Tumor mutational burden
    |
    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • FLT3 (Fms-related tyrosine kinase 3) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • ARID1A (AT-rich interaction domain 1A) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • ATRX (ATRX Chromatin Remodeler) • ARID1B (AT-Rich Interaction Domain 1B) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • EPAS1 (Endothelial PAS domain protein 1) • FLT4 (Fms-related tyrosine kinase 4) • CDH23 (Cadherin Related 23) • FUBP1 (Far Upstream Element Binding Protein 1)
    |
    TP53 mutation • TMB-H • PIK3CA mutation • ARID1A mutation