FSIP2 (Fibrous Sheath Interacting Protein 2)

News alerts, weekly reports and conference planners

Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial. (PubMed, BMC Med)

Adjuvant tislelizumab, lenvatinib, and capecitabine demonstrated clinical activity and tolerable safety in patients with resected BTC. Despite not meeting the primary endpoint, continued follow-up and further evaluation are warranted to better define the potential role of this combination regimen.

1 month ago

P2 data • Journal • PD(L)-1 Biomarker

FSIP2 (Fibrous Sheath Interacting Protein 2)

Lenvima (lenvatinib) • Tevimbra (tislelizumab-jsgr) • capecitabine

3ms

Mapping the Somatic Mutation Landscape of Familial NF2-Related Schwannomatosis using Whole-Exome Sequencing. (PubMed, Int J Med Sci)

Missense mutations and C>T transitions were the most common alteration types. TTN, CR2, FLG, and FSIP2 demonstrated elevated mutation frequencies in these familial NF2-SWN patients, indicating that these mutations may contribute to the development and progression of familial NF2-SWN.

3 months ago

Retrospective data • Journal

NF2 (Neurofibromin 2) • FSIP2 (Fibrous Sheath Interacting Protein 2)

4ms

The FSIP Family: Roles in Health and Cancer. (PubMed, Cancers (Basel))

Their restricted expression in normal tissues, together with their consistent association with poor prognosis across cancer types, highlights their potential as diagnostic biomarkers, therapeutic targets, and prognostic indicators. This review summarizes the structural features and biological functions of the FSIP family, emphasizes recent advances in elucidating their regulatory roles in tumor-associated signaling pathways, and outlines the major challenges and future perspectives in this emerging field.

4 months ago

Review • Journal

FSIP1 (Fibrous Sheath Interacting Protein 1) • FSIP2 (Fibrous Sheath Interacting Protein 2)

almost3years

Multiregional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Tumors from Latinos. (PubMed, Cancer Res Commun)

Our findings of a higher frequency of a poor prognosis associated molecular subtype in Latinos and a possible new aflatoxin gastric cancer etiology also advance cancer disparities research. Our study contributes to advancing our knowledge of gastric carcinogenesis, diagnostics, and cancer health disparities.

almost 3 years ago

Journal

RAD50 (RAD50 Double Strand Break Repair Protein) • FAT4 (FAT Atypical Cadherin 4) • FSIP2 (Fibrous Sheath Interacting Protein 2) • PCDHA1 (Protocadherin Alpha 1) • RECQL4( RecQ Like Helicase 4)

RAD50 mutation • RECQL4 mutation

3years

Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer. (PubMed, JAMA Netw Open)

Analyses of variant signatures and double-hit events revealed potentially important mechanisms for HDGC tumorigenesis. Findings from the present study may provide helpful information for further investigations of HDGC.

3 years ago

Journal • BRCA Biomarker

BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • FGFR3 (Fibroblast growth factor receptor 3) • STK11 (Serine/threonine kinase 11) • PALB2 (Partner and localizer of BRCA2) • CDH1 (Cadherin 1) • RAD51C (RAD51 paralog C) • IGF1 (Insulin-like growth factor 1) • MUC4 (Mucin 4, Cell Surface Associated) • CTNNA1 (Catenin Alpha 1) • ASPSCR1 (ASPSCR1 Tether For SLC2A4) • FSIP2 (Fibrous Sheath Interacting Protein 2) • PRSS1 (Serine Protease 1) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • LZTR1 (Leucine Zipper Like Transcription Regulator 1)

almost4years

Genomic analyses reveal SCN7A is associated with the prognosis of esophageal squamous cell carcinoma. (PubMed, Esophagus)

In summary, this study provided comprehensive analysis of the somatic mutation profiles of ESCC, and identified SCN7A and Signature_15 for the prognosis of ESCC for the first time. The findings might serve as a conceptual basis for molecular diagnosis and prevention of ESCC.

almost 4 years ago

Journal

FSIP2 (Fibrous Sheath Interacting Protein 2) • HRNR (Hornerin)

almost4years

Comprehensive Genomic and Epigenomic Analyses on Transcriptomic Regulation in Stomach Adenocarcinoma. (PubMed, Front Genet)

According to the results, these aforementioned genes exerted crucial roles in the development of invasive STAD. Our findings on transcriptomic regulation genomically and epigenetically facilitate the understanding of the STAD pathology from different aspects, which help to develop efficient anti-STAD therapy.

almost 4 years ago

Journal

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ARID1A (AT-rich interaction domain 1A) • KMT2D (Lysine Methyltransferase 2D) • RANBP2 (RAN Binding Protein 2) • ZFHX3 (Zinc Finger Homeobox 3) • FSIP2 (Fibrous Sheath Interacting Protein 2) • SPECC1 (Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1)

PIK3CA mutation • ARID1A mutation

over4years

Combination of 35-Gene Mutation Profile and Radiotherapy Dosimetry Predicts the Therapeutic Outcome of Definitive Chemoradiation in Patients With Esophageal Squamous Cell Carcinoma. (PubMed, Front Oncol)

Our cohort showed higher MUC17 (79.5% vs. 5.7%), FSIP2 (18.2% vs. 6.2%), and SYNE1 (38.6% vs. 11.0%) mutation rates and lower TP53 (38.6% vs. 68.7%) mutation rates than the ESCC cohorts from The Cancer Genome Atlas. In conclusion, by using a combination of a 35-gene mutation profile and radiotherapy dosimetry, mutations in FSIP2 and SYNE1 as well as lung V30 were identified as potential predictors for developing a prediction model for clinical outcomes in patients with ESCC administered definitive CCRT.

over 4 years ago

Clinical • Journal

TP53 (Tumor protein P53) • FSIP2 (Fibrous Sheath Interacting Protein 2) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1)

TP53 mutation • FSIP2 mutation