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    BIOMARKER:

    FSCN1 elevation

    i
    Other names: FSCN1, Fascin Actin-Bundling Protein 1, P55, SNL, 55 KDa Actin-Bundling Protein, FLJ38511, Fascin, FAN1, HSN, Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus), Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like), Epididymis Secretory Sperm Binding Protein, Fascin Homolog 1, Actin-Bundling Protein, Singed-Like (Fascin Homolog, Sea Urchin), Singed, Drosophila, Homolog-Like, Actin Bundling Protein, Singed-Like Protein
    Entrez ID:
    6624
    almost2years
    N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma. (PubMed, Clin Exp Pharmacol Physiol)
    Their tumour-suppressive effects were abolished through overexpressing FSCN1. Overall, HPV E6/E7 advanced CSCC development through upregulating METTL14/IGF2BP3-mediated FSCN1 m6A modification.
    Journal
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    FSCN1 (Fascin Actin-Bundling Protein 1) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • METTL14 (Methyltransferase 14)
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    FSCN1 elevation
    2years
    Relevance and mechanism of STAT3/miR-221-3p/Fascin-1 axis in EGFR TKI resistance of triple-negative breast cancer. (PubMed, Mol Cell Biochem)
    In our study, we observed that the TNBC cell lines MDA-MB-231 and MDA-MB-468 exhibited resistance to Gefitinib...Moreover, we propose that STAT3 regulates the expression of miR-221-3p/FSCN1 and therefore modulates resistance to EGFR TKI therapy in TNBC. Combining EGFR TKI therapy with inhibition of FSCN1 or STAT3 may offer a promising new therapeutic option for TNBC.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • MIR221 (MicroRNA 221) • FSCN1 (Fascin Actin-Bundling Protein 1)
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    FSCN1 elevation • miR-221 expression
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    gefitinib
    over2years
    CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing. (PubMed, Cell Signal)
    Elevated circFSCN1 induces tumor progression and EMT in BC via enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p. Targeting circFSCN1, a novel identified target, may be conducive in impeding BC progression and providing survival benefits for patients with BC.
    Journal
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    MDM2 (E3 ubiquitin protein ligase) • FSCN1 (Fascin Actin-Bundling Protein 1) • MIR145 (MicroRNA 145)
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    FSCN1 elevation