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DRUG CLASS:

Free radical stimulant

8d
Trial termination • Metastases
|
gemcitabine • 5-fluorouracil • capecitabine • sirolimus • racemetyrosine (SM-88)
1m
Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3. (PubMed, J Nanobiotechnology)
Mice achieving remission through NBTXR3 + PRT + αPD1 exhibited a robust memory immune response, effectively inhibiting growth of subsequent tumors from three distinct lung cancer cell lines. Proton IRT combined with NBTXR3 offers enhanced tumor control and survival rates over photon-based treatments in managing αPD1-resistant lung cancer, indicating its potential as a potent systemic therapy.
Journal • PD(L)-1 Biomarker • IO biomarker
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IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule) • GZMB (Granzyme B) • TGFB1 (Transforming Growth Factor Beta 1) • NKG7 (Natural Killer Cell Granule Protein 7)
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IFNG expression
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Hensify (crystalline hafnium oxide)
3ms
New trial
4ms
TES2022: Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo (clinicaltrials.gov)
P4, N=1408, Recruiting, Ministry of Public Health, Democratic Republic of the Congo | Active, not recruiting --> Recruiting
Enrollment open
6ms
anal HSIL HIV-: Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL (clinicaltrials.gov)
P2, N=17, Active, not recruiting, Frantz Viral Therapeutics, LLC | Trial completion date: Aug 2024 --> Dec 2024
Trial completion date
6ms
NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer (clinicaltrials.gov)
P1, N=24, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Mar 2024 --> Mar 2026 | Trial primary completion date: Mar 2024 --> Mar 2026
Trial completion date • Trial primary completion date
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Hensify (crystalline hafnium oxide)
7ms
Enrollment closed • Metastases
|
Hensify (crystalline hafnium oxide)
7ms
HopES: SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma (clinicaltrials.gov)
P2, N=31, Active, not recruiting, Sarcoma Oncology Research Center, LLC | Trial completion date: Oct 2023 --> Mar 2025 | Trial primary completion date: Jan 2023 --> Dec 2024
Trial completion date • Trial primary completion date • Metastases
|
sirolimus • racemetyrosine (SM-88)
8ms
DeTACT-Africa: A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs. (clinicaltrials.gov)
P3, N=3240, Recruiting, University of Oxford | Trial completion date: Dec 2023 --> Sep 2024 | Trial primary completion date: Dec 2023 --> Mar 2024
Trial completion date • Trial primary completion date • Combination therapy • Head-to-Head
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • KCNQ1OT1 (KCNQ1 Opposite Strand/Antisense Transcript 1) • KCNH2 (Potassium Voltage-Gated Channel Subfamily H Member 2)
8ms
Trial completion • Enrollment change • Combination therapy • Head-to-Head
|
ABCB1 (ATP Binding Cassette Subfamily B Member 1) • KCNQ1OT1 (KCNQ1 Opposite Strand/Antisense Transcript 1) • KCNH2 (Potassium Voltage-Gated Channel Subfamily H Member 2)
8ms
New P4 trial
8ms
ALAQ: Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects (clinicaltrials.gov)
P1, N=16, Recruiting, University of Oxford | Trial completion date: Aug 2023 --> Aug 2026 | Trial primary completion date: Aug 2023 --> Aug 2026
Trial completion date • Trial primary completion date
9ms
MALCOV: Malaria as a Risk Factor for COVID-19 in Western Kenya and Burkina Faso (clinicaltrials.gov)
P3, N=143, Completed, Liverpool School of Tropical Medicine | Recruiting --> Completed | Trial completion date: Jul 2023 --> Feb 2024
Trial completion • Trial completion date
9ms
ART_CIN_II: Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3) (clinicaltrials.gov)
P2, N=78, Recruiting, Frantz Viral Therapeutics, LLC | Trial completion date: Mar 2025 --> Dec 2025 | Trial primary completion date: Jul 2024 --> Jul 2025
Trial completion date • Trial primary completion date
9ms
anal HSIL HIV-: Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL (clinicaltrials.gov)
P2, N=17, Active, not recruiting, Frantz Viral Therapeutics, LLC | Recruiting --> Active, not recruiting | N=48 --> 17
Enrollment closed • Enrollment change
9ms
TES2022: Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo (clinicaltrials.gov)
P4, N=1408, Active, not recruiting, Ministry of Public Health, Democratic Republic of the Congo | Recruiting --> Active, not recruiting
Enrollment closed
11ms
Study 1100: NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy (clinicaltrials.gov)
P1, N=145, Recruiting, Nanobiotix | Trial primary completion date: Mar 2023 --> Apr 2027
Trial primary completion date • Metastases
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Keytruda (pembrolizumab) • Opdivo (nivolumab) • Hensify (crystalline hafnium oxide)
11ms
MEFI_IV: In Vivo Efficacy of Artemether-Lumefantrine, Amodiaquine-Artesunate, Dihydroartemisinin-Piperaquine, and Pironaridine-Artesunate in Mozambique (clinicaltrials.gov)
P4, N=870, Active, not recruiting, Centro de Investigacao em Saude de Manhica | Trial completion date: Sep 2023 --> Jul 2024
Trial completion date
1year
NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer (clinicaltrials.gov)
P1, N=24, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Oct 2023 --> Oct 2025 | Trial primary completion date: Oct 2023 --> Oct 2025
Trial completion date • Trial primary completion date
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carboplatin • paclitaxel • docetaxel • capecitabine • oxaliplatin • leucovorin calcium • fluorouracil topical • Hensify (crystalline hafnium oxide)
1year
TES2022: Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo (clinicaltrials.gov)
P4, N=1408, Recruiting, Ministry of Public Health, Democratic Republic of the Congo
New P4 trial
1year
Assessment of the Spatial Bio-Distribution of NBTXR3 for Locally Advanced or Borderline-Resectable Pancreatic Ductal Adenocarcinoma (LAPC or BRPC) Patients Undergoing Radiation Therapy. (PubMed, Int J Radiat Oncol Biol Phys)
The raw volume of NBTXR3 injected in the pancreas did not significantly change over the duration of the three weeks of treatment. We also did not observe significant changes in the NBTXR3 volume overlapping the GTV in most cases. The stability of NBTXR3 was demonstrated during RT.
Journal • Metastases
|
Hensify (crystalline hafnium oxide)
1year
Novel Radioenhancer NBTXR3 Activated by Radiotherapy in Cisplatin-Ineligible Locally Advanced HNSCC Patients: Final Results of a Phase I Trial. (PubMed, Int J Radiat Oncol Biol Phys)
NBTXR3 IT injection followed by activation with RT was confirmed to be feasible and well tolerated in elderly or frail patients with LA HNSSC and significant comorbidities. The high rate of best overall response suggests that NBTXR3+RT is effective in this elderly population ineligible to cisplatin with a high unmet medical need. These results support our ongoing phase III study comparing NBTXR3/RT ± cetuximab vs. RT ± cetuximab in platinum-based chemotherapy ineligible elderly patients with LA-HNSCC: NANORAY 312 (NCIT04892173).
P1 data • Journal • Metastases
|
Erbitux (cetuximab) • Hensify (crystalline hafnium oxide)
1year
OASIS: Oral SM-88 in Patients With Metastatic HR+/HER2- Breast Cancer (clinicaltrials.gov)
P2, N=11, Terminated, Georgetown University | N=50 --> 11 | Trial completion date: May 2025 --> Feb 2023 | Active, not recruiting --> Terminated | Trial primary completion date: May 2024 --> Feb 2023; Lack of efficacy
Enrollment change • Trial completion date • Trial termination • Trial primary completion date • Metastases
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • CD4 (CD4 Molecule)
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ER positive • HER-2 negative
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sirolimus • racemetyrosine (SM-88)
over1year
Phase I study of endoscopic ultrasound (EUS)-guided NBTXR3 delivery activated by radiotherapy (RT) for locally advanced or borderline resectable pancreatic cancer (LAPC or BRPC) (ESMO 2023)
Conclusions The RP2D of NBTXR3 for LAPC is 42% of GTV. The successful CR and shift to resectability in this patient population, along with the response and CA19-9 decrease and normalization suggest promising anti-tumor efficacy of NBTXR3/RT.
P1 data • Metastases
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CA 19-9 (Cancer antigen 19-9)
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Hensify (crystalline hafnium oxide)
over1year
Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection. (PubMed, JCI Insight)
This response was further significantly enhanced by the injection of the tumor to be irradiated with NBTXR3 nanoparticles. Tumors of mice treated with the triple combination exhibited increased infiltration and activation of cytotoxic immune cells. This triple combination eradicated both tumors in 37.5% of the treated mice and showed robust long-term immunity to cancer.
Journal
|
Hensify (crystalline hafnium oxide)
over1year
A phase Ib/II trial of PEP503 (NBTXR3, radioenhancer) with radiotherapy and chemotherapy in patients with rectal cancer. (PubMed, Nanomedicine (Lond))
Patients will receive a single intratumoral injection of the nanoparticles, followed by radiotherapy and intravenous infusion of fluorouracil or oral capecitabine concurrently. This study will be the first prospective, open-label, single-arm, nonrandomized study to investigate the efficacy and safety profile of PEP503 (NBTXR3) nanoparticles with radiotherapy and chemotherapy in these patients. Trial registration number: NCT02465593 (ClinicalTrials.gov).
P1/2 data • Review • Journal
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5-fluorouracil • capecitabine • Hensify (crystalline hafnium oxide)
over1year
Enrollment open • Combination therapy • Metastases
|
Hensify (crystalline hafnium oxide)
over1year
Early biological impacts of radiotherapy-activated NBTXR3 nanoparticles (AACR 2023)
Following LMP, we measured a significant increase of in lipid peroxidation. These first elements allow a better understanding of the early biological consequences induced by NBTXR3+RT, compared to RT alone.
PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8)
|
Hensify (crystalline hafnium oxide)
almost2years
OASIS: Oral SM-88 in Patients With Metastatic HR+/HER2- Breast Cancer (clinicaltrials.gov)
P2, N=50, Active, not recruiting, Georgetown University | Recruiting --> Active, not recruiting
Enrollment closed • Metastases
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • CD4 (CD4 Molecule)
|
ER positive • HER-2 negative
|
sirolimus • racemetyrosine (SM-88)
2years
Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer. (PubMed, J Nanobiotechnology)
Our results strongly attest to the efficacy and validity of combining nanoparticle-enhanced radiotherapy and simultaneous blockade of multiple immune checkpoint receptors and provide a pre-clinical rationale for investigating its translation into human patients.
Journal
|
LAG3 (Lymphocyte Activating 3) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2)
|
Hensify (crystalline hafnium oxide)
over2years
NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy (clinicaltrials.gov)
P1, N=145, Recruiting, Nanobiotix | N=60 --> 145 | Trial completion date: Mar 2023 --> May 2028
Enrollment change • Trial completion date
|
PD-1 (Programmed cell death 1)
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Hensify (crystalline hafnium oxide)
over2years
Radiotherapy-activated NBTXR3 nanoparticles modulate cancer cell immunogenicity and TCR repertoire. (PubMed, Cancer Cell Int)
These results indicate that radiotherapy-activated NBTXR3 can act as an effective immunomodulator, modifying tumor cell immunogenicity and impacting the lymphocyte population.
Journal • IO biomarker
|
CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CD68 (CD68 Molecule)
|
Hensify (crystalline hafnium oxide)
over2years
Inhibition of stearoyl-CoA desaturase 1 potentiates anti-tumor activity of amodiaquine in non-small cell lung cancer. (PubMed, Biol Pharm Bull)
Combinational treatment of autophagy inhibition and SCD1 inhibition achieves synergistic anti-tumor effect both in vitro and in vivo. This combinational approach could be a promising strategy for NSCLC treatment.
Journal
|
SCD (Stearoyl-CoA Desaturase)
over2years
Nanoparticle-enhanced radiotherapy combined with triple blockade of PD1, LAG3, and TIGIT enhances anti-tumor immune activation (AACR 2022)
Simultaneous inhibition of LAG3 and TIGIT in tandem with PD1 blockade and NBTXR3-enhanced radiotherapy promotes immune activation at the irradiated site. In addition, abscopal immune responses are improved with blockade of LAG3 and TIGIT. These results suggest that blockade of multiple immune checkpoints in parallel with NBTXR3-mediated radiotherapy may be effective in metastatic cancers.[Y.H.
PD(L)-1 Biomarker • IO biomarker
|
LAG3 (Lymphocyte Activating 3) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2)
|
Hensify (crystalline hafnium oxide)
almost3years
Combined effect of heat shock protein inhibitor geldanamycin and free radicals on photodynamic therapy of prostate cancer. (PubMed, J Mater Chem B)
Simultaneously, the inhibition of Hsp90 can inhibit the overexpression of its client proteins such as anti-apoptotic proteins (survivin) and androgen receptor (AR), thereby improving the efficacy of PDT and inducing prostate cancer cell apoptosis. Results show that the nanosystem enhances PDT by combining free radicals and 17-AAG, exhibiting a good anticancer effect on prostate cancer cells but less toxicity on normal cells.
Journal
|
AR (Androgen receptor) • BIRC5 (Baculoviral IAP repeat containing 5) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
almost3years
A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model. (PubMed, J Nanobiotechnology)
NBTXR3 nanoparticle in combination with radioimmunotherapy significantly improves anti-PD1 resistant lung tumor control via promoting antitumor immune response.
Preclinical • Journal
|
CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
|
Hensify (crystalline hafnium oxide)
3years
[VIRTUAL] Overcoming Resistance to Anti-PD-1 With Tumor Agnostic NBTXR3: From Bench to Bedside (ASTRO 2021)
The clinical efficacy of NBTXR3+RT has been demonstrated as a single agent in STS. Here we demonstrate that it overcomes resistance to anti-PD-1 treatment mechanisms in mice and led to tumor regression in patients having progressed on anti-PD-1 therapy. These results highlight the potential of NBTXR3+RT to positively impact the immuno-oncology field.
PD(L)-1 Biomarker • IO biomarker • Pan tumor
|
CD8 (cluster of differentiation 8) • FOXP3 (Forkhead Box P3)
|
Hensify (crystalline hafnium oxide)
3years
[VIRTUAL] Digital XP SH 08 - Digital XP Science Highlights 08 - Biology (ASTRO 2021)
This Science Highlights session will showcase abstracts that are noteworthy in the field of Radiation and Cancer Biology.  The abstracts that will be discussed during this session are: A targeted gene expression risk score predicts meningioma outcomes and responses to radiotherapy Identification of De Novo Pyrimidine Synthesis as a Targetable Vulnerability in a Novel IDH1 Mutant Engineered Astrocytoma Model Overcoming resistance to anti-PD-1 with tumor agnostic NBTXR3: from bench to bedside Focal Adhesion Kinase drives resistance to therapy in HPV-negative head and neck squamous cell carcinoma in a p53-dependent manner CDK4/6 Inhibition and Radiation as a Treatment Strategy to Improve Local Disease Control in Breast Cancers with Poor Prognoses SIRT2 promotes murine melanoma progression through natural killer cell inhibition Click here to view this session on the Digital XP. Be sure to log in.
PD(L)-1 Biomarker • IO biomarker
|
IDH1 (Isocitrate dehydrogenase (NADP(+)) 1)
|
IDH1 mutation
|
Hensify (crystalline hafnium oxide)
3years
Overcoming Resistance to Anti-PD-1 With Tumor Agnostic NBTXR3: From Bench to Bedside. (PubMed, Int J Radiat Oncol Biol Phys)
The clinical efficacy of NBTXR3+RT has been demonstrated as a single agent in STS. Here we demonstrate that it overcomes resistance to anti-PD-1 treatment mechanisms in mice and led to tumor regression in patients having progressed on anti-PD-1 therapy. These results highlight the potential of NBTXR3+RT to positively impact the immuno-oncology field.
Journal • PD(L)-1 Biomarker • IO biomarker • Pan tumor
|
CD8 (cluster of differentiation 8) • FOXP3 (Forkhead Box P3)
|
Hensify (crystalline hafnium oxide)
3years
Dual blockade of LAG3 and TIGIT improves the treatment efficacy of a nanoparticle-mediated immunoradiation in anti-PD1 resistant lung cancer in mice (SITC 2021)
Furthermore, Nanostring transcriptomic analysis of cells isolated from the tumors of mice thus treated showed evidence of classical two-step immunological priming, with an elevation of innate immune genes at the primary tumor and full-blown activation of the immune system within the secondary tumor. Conclusions Blockade of TIGIT and LAG3 with NBTXR3+XRT+aPD1 improved CD8+ T-cell proliferation, augmented the antitumor response at both irradiated and unirradiated (abscopal) tumors, and induced potent long-term antitumor memory in mice.
Preclinical
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CD8 (cluster of differentiation 8) • LAG3 (Lymphocyte Activating 3) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2)
|
CD8 expression
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Hensify (crystalline hafnium oxide)
3years
Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features. (PubMed, J Oncol)
Adverse effects are dose-dependent, though most common with chloroquine, hydroxychloroquine, amodiaquine, and other aminoquinolines are gastrointestinal changes, blurred vision ventricular arrhythmias, cardiac arrest, QTc prolongation, severe hypoglycemia with loss of consciousness, and retinopathy, and they are more common with chloroquine than with hydroxychloroquine and amodiaquine due to pharmacokinetic features. The low cost and availability on the world market have converted aminoquinolines into "star drugs" for pharmaceutical repurposing, but a continuous pharmacovigilance is necessary because these antimalarials have multiple modes of action/unwanted targets, relatively narrow therapeutic windows, recurrent adverse effects, and related poisoning self-treatment. Therefore, their use must obey strict rules, ethical and medical prescriptions, and clinical and laboratory monitoring.
Clinical • Review • Journal
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CCND1 (Cyclin D1) • SQSTM1 (Sequestosome 1) • LAMP1 (Lysosomal Associated Membrane Protein 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • BECN1 (Beclin 1) • E2F1 (E2F transcription factor 1)
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hydroxychloroquine • chloroquine phosphate