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    BIOMARKER:

    FOXP1-ABL1 Fusion

    i
    Other names: FOXP1, Forkhead box P1, QRF1, hFKH1B, 12CC4, HSPC215, ABL proto-oncogene 1, ABL, c-ABL, JTK7, p150, ABL1
    Entrez ID:
    25; 27086
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    Rapid molecular response to dasatinib in Ph-like acute lymphoblastic leukemia patients with ABL1 rearrangements: case series and literature review. (PubMed, Ann Hematol)
    All three patients achieved rapid and profound remission with no significant adverse events. Our findings suggest that dasatinib is a potent TKI for the treatment of ABL1-rearranged Ph-like ALL and can be used as a first-line treatment option for such patients.
    Review • Journal
    |
    ABL1 (ABL proto-oncogene 1) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase) • CSF1R (Colony stimulating factor 1 receptor) • FOXP1 (Forkhead Box P1)
    |
    ABL1 fusion • FOXP1-ABL1 Fusion
    |
    dasatinib