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    BIOMARKER:

    FOXO3 underexpression

    i
    Other names: FOXO3, AF6q21, FKHRL1, FOXO2, FOXO3A, Forkhead box O3
    Entrez ID:
    2309
    Related biomarkers:
    Mutation
    1year
    High Expression of FOXO3 in Gastric Cancer Tissues is Associated with Poor Prognosis and Immune Cell Infiltration. (PubMed, Clin Lab)
    We find that FOXO3 is a potential oncogene and that the transcript level of FOXO3 is related to the mutation of TP53 and ARID1A. In addition, FOXO3 may influence immune infiltration and different signal pathways through sponge adsorption of miRNA to impact the prognoses of stomach adenocarcinoma patients.
    Journal • Immune cell
    |
    TP53 (Tumor protein P53) • ARID1A (AT-rich interaction domain 1A) • FOXO3 (Forkhead box O3) • MIR18A (MicroRNA 18a)
    |
    TP53 mutation • ARID1A mutation • FOXO3 underexpression
    over3years
    FOXO3A Expression in Upper Tract Urothelial Carcinoma. (PubMed, Front Oncol)
    Multivariate analyses showed that FOXO3A was a significant predictor for OS (HR 2.145, P = 0.014) and RFS (HR 2.227, P = 0.010) in UTUC patients. Our results indicate that FOXO3A may be involved in the recurrence of UTUC and that it has certain clinical value in the therapeutic targeting and prognostic evaluation of UTUC.
    Journal
    |
    FOXO3 (Forkhead box O3)
    |
    FOXO3 underexpression