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    BIOMARKER:

    FOXO3 rs75544369

    i
    Other names: FOXO3, AF6q21, FKHRL1, FOXO2, FOXO3A, Forkhead box O3
    Entrez ID:
    2309
    Related biomarkers:
    Expression
    Mutation
    Associations

    News

    Trials
    over4years
    [VIRTUAL] FOXO3 polymorphisms were correlated with gefitinib-induced hepatotoxicity in patients with non-small cell lung cancer. (ASCO 2020)
    FOXO3 rs4946935 and FOXO3 rs75544369 are predictive biomarkers for gefitinib-induced hepatotoxicity in NSCLC patients. The mechanism underlying the association between FOXO3 polymorphisms and gefitinib-induced hepatotoxicity are worth investigating in further studies. Research Funding: National Natural Science Foundation of China
    Clinical
    |
    EGFR (Epidermal growth factor receptor) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • FOXO3 (Forkhead box O3)
    |
    EGFR mutation • FOXO3 rs4946935 • FOXO3 rs75544369
    |
    gefitinib