FOXO3 rs4946935

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Entrez ID:

2309

Related biomarkers:

Expression

Mutation

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1year

ACVR2B polymorphism, Adiponectin, and GDF-15 levels as biomarkers for cachexia in gastrointestinal cancer. (PubMed, Sci Rep)

However, there was no significant difference in the levels of these cytokines between cachectic men and women. The results suggest the rs2268757 SNP in the ACVR2B gene, adiponectin, and GDF-15 as potential biomarkers of cachexia in gastrointestinal cancer.

1 year ago

Journal

GDF15 (Growth differentiation factor 15) • FOXO3 (Forkhead box O3) • SELP (Selectin P) • ACVR2B (Activin A Receptor Type 2B)

GDF15 elevation • FOXO3 rs4946935

3years

FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy. (PubMed, Acta Pharm Sin B)

This study reveals that FOXO3 mutation, leading to autophagic imbalance, plays important role in gefitinib-induced hepatotoxicity, especially for patients with high concentration of gefitinib. In conclusion, FOXO3 mutation is an effective predictor and erlotinib might be an appropriately and well-tolerated treatment option for patients carrying rs4946935 AA.

3 years ago

Journal

FOXO3 (Forkhead box O3)

FOXO3 rs4946935

erlotinib • gefitinib

over5years

[VIRTUAL] FOXO3 polymorphisms were correlated with gefitinib-induced hepatotoxicity in patients with non-small cell lung cancer. (ASCO 2020)

FOXO3 rs4946935 and FOXO3 rs75544369 are predictive biomarkers for gefitinib-induced hepatotoxicity in NSCLC patients. The mechanism underlying the association between FOXO3 polymorphisms and gefitinib-induced hepatotoxicity are worth investigating in further studies. Research Funding: National Natural Science Foundation of China

over 5 years ago

Clinical

EGFR (Epidermal growth factor receptor) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • FOXO3 (Forkhead box O3)

EGFR mutation • FOXO3 rs4946935 • FOXO3 rs75544369

gefitinib