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    BIOMARKER:

    FOXM1 rs3742076_G

    i
    Other names: FOXM1, Forkhead Box M1, M-Phase Phosphoprotein 2, HFH-11, MPP2, Hepatocyte Nuclear Factor 3 Forkhead Homolog 11, Winged-Helix Factor From INS-1 Cells, MPM-2 Reactive Phosphoprotein 2, Forkhead-Related Protein FKHL16, Transcription Factor Trident, HNF-3/Fork-Head Homolog 11, Forkhead Box Protein M1, MPHOSPH2, FKHL16, HFH11, HNF-3, INS-1, A Novel Forkhead Box M1 Isoform FOXM1D, Forkhead Drosophila Homolog-Like 16, Forkhead Box M1-D, TRIDENT, Trident, FOXM1A, FOXM1B, FOXM1C, MPP-2, PIG29, FOXM1, TGT3, WIN
    Entrez ID:
    2305
    Related biomarkers:
    Expression
    over3years
    FOXM1 variant contributes to gefitinib resistance via activating wnt/β-catenin signal pathway in non-small cell lung cancer patients. (PubMed, Clin Cancer Res)
    These findings characterized rs3742076_G as a gain-of-function polymorphism in mediating gefitinib resistance and tumor aggressiveness, and highlighted the variant as a predictive biomarker in guiding gefitinib treatment.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • FOXM1 (Forkhead Box M1)
    |
    EGFR mutation • FOXM1 rs3742076_G
    |
    gefitinib