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    BIOMARKER:

    FOXA1 underexpression

    i
    Other names: FOXA1, Forkhead Box A1, Hepatocyte Nuclear Factor 3-Alpha, Forkhead Box Protein A1, Transcription Factor 3A, HNF-3-Alpha, HNF-3A, TCF-3A, HNF3A, TCF3A, Hepatocyte Nuclear Factor 3 Alpha
    Entrez ID:
    3169
    Related biomarkers:
    Expression
    Mutation
    Others
    Associations

    News

    Trials
    over2years
    Increased FOXA1 levels induce apoptosis and inhibit proliferation in FOXA1-low expressing basal breast cancer cells. (PubMed, Am J Cancer Res)
    When introduced into MDA-MB-231 cells, ESR1 counteracts the tumor suppressor roles of FOXA1 by altering the FOXA1-regulated gene transcription and the two proteins together maintain the tumor progression in vivo. Our cumulative results suggest that FOXA1 suppresses the basal breast cancer cells with FOXA1-low expressing status independent of ESR1 by inducing apoptosis and inhibiting cell proliferation, thereby implicating its potential therapeutic role in this group of breast cancer.
    Journal
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    ER (Estrogen receptor) • FOXA1 (Forkhead Box A1)
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    FOXA1 underexpression