^
Contact us  to learn more about
our Premium Content:  News alerts, weekly reports and conference planners
DRUG:

fosciclopirox (CPX-POM)

i
Other names: CPX-POM, ciclopirox prodrug
Associations
Trials
Company:
BioNovus, University of Kansas Medical Center
Drug class:
γ-secretase inhibitor
Associations
Trials
9ms
Safety, Dose Tolerance, Pharmacokinetics, and Pharmacodynamics Study of CPX-POM in Patients With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=9, Completed, CicloMed LLC | Trial completion date: Dec 2022 --> Apr 2023 | Trial primary completion date: Dec 2022 --> Apr 2023
Trial completion date • Trial primary completion date • Metastases
|
fosciclopirox (CPX-POM)
9ms
CPX-POM-003: Study of Fosciclopirox in Patients With Relapsed/Refractory Acute Myeloid Leukemia (clinicaltrials.gov)
P1/2, N=18, Terminated, CicloMed LLC | Phase classification: P1b/2a --> P1/2 | N=28 --> 18 | Recruiting --> Terminated; Discontinued
Phase classification • Enrollment change • Trial termination • Combination therapy
|
cytarabine • fosciclopirox (CPX-POM)
9ms
Trial completion
|
fosciclopirox (CPX-POM)
over3years
Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. (PubMed, Cell Death Dis)
Additionally, there was a reduction in Presenilin 1 and Hes-1 expression in the bladder tissues of CPX-POM treated animals. Following the completion of the first-in-human Phase 1 trial (NCT03348514), the pharmacologic activity of fosciclopirox is currently being characterized in a Phase 1 expansion cohort study of muscle-invasive bladder cancer patients scheduled for cystectomy (NCT04608045) as well as a Phase 2 trial of newly diagnosed and recurrent urothelial cancer patients scheduled for transurethral resection of bladder tumors (NCT04525131).
Journal
|
HES1 (Hes Family BHLH Transcription Factor 1)
|
fosciclopirox (CPX-POM)
almost5years
Clinical • PK/PD data
|
NOTCH1 (Notch 1) • CD8 (cluster of differentiation 8) • PCNA (Proliferating cell nuclear antigen)
|
cisplatin • fosciclopirox (CPX-POM)
almost5years
Safety, dose tolerance, pharmacokinetics, and pharmacodynamics of fosciclopirox (CPX-POM) in patients with advanced solid tumors. (ASCO-GU 2020)
IV CPX-POM was well tolerated with treatment-related AEs primarily CNS-related. At MTD, systemic and urinary CPX exposures exceeding in vitro IC50 values by several-fold. The 900 mg/m2 dose is currently being evaluated in an expansion cohort study in cisplatin-ineligible muscle invasive bladder cancer patients scheduled for cystectomy.
Clinical • PK/PD data
|
NOTCH1 (Notch 1) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
|
cisplatin • fosciclopirox (CPX-POM)
almost5years
Safety, dose tolerance, pharmacokinetics, and pharmacodynamics of fosciclopirox (CPX-POM) in patients with advanced solid tumors. (ASCO-GU 2020)
IV CPX-POM was well tolerated with treatment-related AEs primarily CNS-related. At MTD, systemic and urinary CPX exposures exceeding in vitro IC50 values by several-fold. The 900 mg/m2 dose is currently being evaluated in an expansion cohort study in cisplatin-ineligible muscle invasive bladder cancer patients scheduled for cystectomy.
Clinical • PK/PD data
|
NOTCH1 (Notch 1) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
|
cisplatin • fosciclopirox (CPX-POM)
almost5years
Clinical • PK/PD data
|
NOTCH1 (Notch 1) • CD8 (cluster of differentiation 8) • PCNA (Proliferating cell nuclear antigen)
|
cisplatin • fosciclopirox (CPX-POM)