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DRUG:

Folotyn (pralatrexate)

i
Other names: PDX, 10-propargyl-10-deazaaminopterin
Company:
Assertio, Aurobindo, CASI, Mundipharma
Drug class:
THF dehydrogenase inhibitor
11d
New trial
|
Epidaza (chidamide) • Folotyn (pralatrexate)
25d
Enrollment open
|
Beleodaq (belinostat) • Folotyn (pralatrexate) • soquelitinib (CPI-818)
2ms
The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity. (PubMed, Front Pharmacol)
Using proliferation assays, we investigated their potential to protect cancer cells from cytotoxicity of the antifolates methotrexate, pemetrexed (Alimta), raltitrexed (Tomudex) and pralatrexate (Folotyn). However, protection from inhibition by various antifolates was solely achieved by l-LV and dl-LV. In general l-LV acts similar to the dl-LV formulations, however disparate effects were observed when d-LV and l-LV were used in combination, conceivably by d-LV affecting (anti)folate transport and intracellular metabolism.
Journal
|
TYMS (Thymidylate Synthetase)
|
5-fluorouracil • pemetrexed • methotrexate • leucovorin calcium • Tomudex (raltitrexed) • Folotyn (pralatrexate)
3ms
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas (clinicaltrials.gov)
P1/2, N=13, Active, not recruiting, City of Hope Medical Center | Trial completion date: Jun 2024 --> Dec 2024
Trial completion date
|
ALK (Anaplastic lymphoma kinase)
|
Keytruda (pembrolizumab) • Folotyn (pralatrexate)
3ms
New P3 trial
|
Beleodaq (belinostat) • Folotyn (pralatrexate) • soquelitinib (CPI-818)
3ms
Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL (clinicaltrials.gov)
P2, N=50, Recruiting, University of Virginia | Trial primary completion date: Dec 2026 --> Jun 2026
Trial primary completion date
|
gemcitabine • azacitidine • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
4ms
Targeting CD25+ lymphoma cells with the antibody-drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents. (PubMed, Br J Haematol)
When camidanlumab tesirine-containing combinations were evaluated in four T-cell lymphoma models, the most active partners were everolimus, copanlisib, venetoclax, vorinostat, and pralatrexate, followed by bortezomib, romidepsin, bendamustine, and 5-azacytidine. The strong camidanlumab tesirine single-agent anti-lymphoma activity and the in vitro synergisms with targeted agents identify potential combination partners for future clinical studies.
Journal • Combination therapy
|
IL2RA (Interleukin 2 receptor, alpha)
|
Venclexta (venetoclax) • everolimus • bortezomib • azacitidine • Aliqopa (copanlisib) • Zolinza (vorinostat) • bendamustine • Istodax (romidepsin) • camidanlumab tesirine (ADCT-301) • Folotyn (pralatrexate)
5ms
Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL (clinicaltrials.gov)
P2, N=50, Recruiting, University of Virginia | Trial primary completion date: Jun 2026 --> Dec 2026
Trial primary completion date
|
gemcitabine • azacitidine • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
6ms
Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL (clinicaltrials.gov)
P1, N=37, Recruiting, University of Virginia | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Jun 2025
Trial completion date • Trial primary completion date
|
Keytruda (pembrolizumab) • decitabine • Folotyn (pralatrexate)
6ms
Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL (clinicaltrials.gov)
P2, N=50, Recruiting, University of Virginia | Phase classification: P2b --> P2 | Trial primary completion date: Jun 2024 --> Jun 2026
Phase classification • Trial primary completion date
|
gemcitabine • azacitidine • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
8ms
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas (clinicaltrials.gov)
P1/2, N=13, Active, not recruiting, City of Hope Medical Center | Trial primary completion date: Jun 2024 --> May 2023
Trial primary completion date
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK negative
|
Keytruda (pembrolizumab) • Folotyn (pralatrexate)
9ms
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas (clinicaltrials.gov)
P1/2, N=13, Active, not recruiting, City of Hope Medical Center | Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
Trial completion date • Trial primary completion date
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK negative
|
Keytruda (pembrolizumab) • Folotyn (pralatrexate)
1year
CRESCENDO: To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL (clinicaltrials.gov)
P3, N=504, Recruiting, Acrotech Biopharma Inc. | Not yet recruiting --> Recruiting
Enrollment open
|
ALK (Anaplastic lymphoma kinase) • TNFRSF8 (TNF Receptor Superfamily Member 8) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
TNFRSF8 expression • UGT1A1*1*1
|
doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Beleodaq (belinostat) • Folotyn (pralatrexate)
1year
Strategies to Develop Anti-KIR Mab Lacutamab in Patients with Peripheral T-Cell Lymphoma: Preliminary Monotherapy Clinical Data and Pre-Clinical Combinability Data (ASH 2023)
To further develop novel-lacutamab combinations, the combinability of lacutamab with therapies used in R/R or frontline PTCL e.g., pralatrexate or CHOP, respectively, was tested. These data inform the future development of lacutamab to provide additional therapeutic options that may improve outcomes for PTCL patients, including those who relapse or are refractory to available therapies. A Phase 2 study evaluating the combination of lacutamab with GemOx is ongoing (NCT04984837) based on pre-clinical observations that GemOx improves lacutamab-induced ADCC by NK cells.
Clinical data • Preclinical
|
KIR3DL2 (Killer Cell Immunoglobulin Like Receptor Three Ig Domains And Long Cytoplasmic Tail 2)
|
Folotyn (pralatrexate) • lacutamab (IPH4102)
1year
Patterns of Care and Impact of Initial Treatment in Peripheral T-Cell Lymphoma: Outcome Analysis from the Lymphoma Epidemiology of Outcomes (LEO) and Molecular Epidemiology Resource (MER) Prospective Cohort Study (ASH 2023)
The most common 1st line chemotherapy regimens overall were CHOP-based (N=506, 70%), including 60% receiving CHOP-like chemotherapy in both MER and LEO cohorts (CHOP [N=268, 37%], CHOEP [N=91, 13%] or EPOCH [N=75, 10%]), and 16% with CHOP-like in combination with novel agents in LEO cohort (BV+ [N=41, 9.3%], azacitidine+ [N=11, 2.5%], pralatrexate+ [N=10, 2.3%], lenalidomide+ [N=8, 1.9%]) (Table 1)...Outcomes continue to mature with longitudinal follow-up and ongoing accrual, which poise to shape benchmarks in the contemporary era. The lack of benefit of etoposide adding to CHOP induction and poor overall survival of non-ALCL subtypes underscores the unmet need of therapeutic breakthrough for non-ALCL frontline treatment, particularly through clinical trials with biomarker-guided approaches incorporating novel agents.
Clinical
|
ALK (Anaplastic lymphoma kinase)
|
LDH elevation
|
lenalidomide • azacitidine • etoposide IV • Folotyn (pralatrexate) • Epoch (epoetin beta biosimilar)
1year
New P3 trial
|
ALK (Anaplastic lymphoma kinase) • TNFRSF8 (TNF Receptor Superfamily Member 8) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
TNFRSF8 expression • UGT1A1*1*1
|
doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Beleodaq (belinostat) • Folotyn (pralatrexate)
1year
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas (clinicaltrials.gov)
P1/2, N=13, Active, not recruiting, City of Hope Medical Center | Recruiting --> Active, not recruiting | N=40 --> 13
Enrollment closed • Enrollment change
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK negative
|
Keytruda (pembrolizumab) • Folotyn (pralatrexate)
over1year
Predictive model for treatment outcomes of peripheral T-cell lymphoma, not otherwise specified, in Taiwanese patients. (PubMed, J Formos Med Assoc)
PTCL-NOS patients have a dismal prognosis in Taiwan. Novel agents may improve the outcomes of PTCL-NOS patients. The usefulness of the novel prognostic index for PTCL-NOS needs further validation.
Journal • Predictive model
|
Folotyn (pralatrexate)
over1year
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas (clinicaltrials.gov)
P1/2, N=40, Recruiting, City of Hope Medical Center | Trial completion date: Apr 2023 --> Dec 2023 | Trial primary completion date: Apr 2023 --> Dec 2023
Trial completion date • Trial primary completion date
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK negative
|
Keytruda (pembrolizumab) • Folotyn (pralatrexate)
over1year
Tailoring Therapy In PTCL (SOHO 2023)
There are several approved agents for the treatment of relapsed T-cell lymphomas including pralatrexate, romidepsin, belinostat, and brentuximab vedotin, but none of them are considered curative. As these studies mature, it is expected that the treatment for TCL will evolve so that each individual patient will be treated based on the biologic and molecular characteristics of their tumor type. The future for TCL remains promising.
IO biomarker
|
ALK (Anaplastic lymphoma kinase) • TNFRSF8 (TNF Receptor Superfamily Member 8) • TET2 (Tet Methylcytosine Dioxygenase 2) • CCR4 (C-C Motif Chemokine Receptor 4) • IL2RA (Interleukin 2 receptor, alpha) • CD70 (CD70 Molecule) • RHOA (Ras homolog family member A) • SYK (Spleen tyrosine kinase) • TBX21 (T-Box Transcription Factor 21) • TP63 (Tumor protein 63) • DUSP22 (Dual Specificity Phosphatase 22) • USP22 (Ubiquitin Specific Peptidase 22) • SIRPA (Signal Regulatory Protein Alpha)
|
TET2 mutation • TNFRSF8 expression
|
Adcetris (brentuximab vedotin) • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
over1year
Dupilumab-associated mycosis fungoides: a cross-sectional study. (PubMed, Arch Dermatol Res)
Treatment strategies included narrow-band UVB therapy, topical corticosteroids, brentuximab, pralatrexate, and acitretin. The results raise the question as to whether the patients had MF misdiagnosed as AD that was unmasked by dupilumab or if MF truly is an adverse effect of treatment with dupilumab. Close monitoring of these patients and further investigation of the relationship between dupilumab and MF can shed more light on this question .
Observational data • Journal
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IL13 (Interleukin 13) • IL4 (Interleukin 4)
|
Adcetris (brentuximab vedotin) • Folotyn (pralatrexate) • Dupixent (dupilumab)
almost2years
Pralatrexate mediates effective killing of gemcitabine-resistant pancreatic cancer: role of mTOR/4E-BP1 signal pathway. (PubMed, Heliyon)
In summary, pralatrexate induces effective inhibition of gemcitabine-resistant pancreatic cancer. This may lead to the expansion of pralatrexate's application and offer benefit to gemcitabine-resistant pancreatic cancer patients in the future.
Journal
|
EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1)
|
gemcitabine • Folotyn (pralatrexate)
almost2years
Tolinapant, a Non-Peptidomimetic Antagonist of Inhibitors of Apoptosis Proteins, cIAP1/2 and XIAP, in Combination with the Hypomethylating Agents, Azacytidine and Decitabine Are Highly Synergistic in in Vitro Models of T Cell Lymphoma (ASH 2022)
In addition, re-expression of RIPK3 in CT26 cells increased lytic cell death on treatment with tolinapant indicating its essential role in the necroptosis pathway.Objectives: 1) Characterize the single-agent activity of tolinapant in a range of TCL lines; 2) Determine the synergy of tolinapant in combination with drugs active against PTCL (romidepsin, pralatrexate) and HMAs (azacytidine-AZA; decitabine-DAC), and 3) Define the role of necroptosis in the mechanism of synergy. Thus, activation of the necroptosis pathway, is a possible mechanism for the high degree of synergy displayed when HMAs are used in combination with tolinapant in the TCL lines in vitro. These data provided the rationale for a phase 1-2 study of the combination of tolinapant and oral decitabine/cedazuridine treatment in relapsed/refractory PTCL (NCT05403450).
Preclinical • Combination therapy • PARP Biomarker
|
ALK (Anaplastic lymphoma kinase) • TNFA (Tumor Necrosis Factor-Alpha) • XIAP (X-Linked Inhibitor Of Apoptosis) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) • RIPK3 (Receptor Interacting Serine/Threonine Kinase 3)
|
azacitidine • Inqovi (decitabine/cedazuridine) • Istodax (romidepsin) • Folotyn (pralatrexate) • tolinapant (ASTX660)
2years
Pembrolizumab in Combination with Epigenetic Therapy Is Safe and Active in Heavily Treated Patients with Peripheral T-Cell Lymphoma (PTCL) and Cutaneous T-Cell Lymphoma (CTCL): Preliminary Results from the Embolden Trial (ASH 2022)
We have demonstrated that epigenetic modifiers, such as decitabine and 5-azacytidine (Marchi et al; Br...Herein, we report on the differential clinical activity of adding the immune checkpoint inhibitor, pembrolizumab, to decitabine, pralatrexate, or the combination and we describe the role of cytokines as a biomarker of treatment response... These preliminary data suggest that the integration of pembrolizumab into an epigenetic backbone is safe and demonstrates encouraging responses in heavily pretreated patients with PTCL and CTCL. Pharmacodynamic data suggests that certain cytokines might have predictive value as biomarkers of disease response and progression. Interestingly, patients that responded (PR/CR) to the study drugs displayed a decline in cytokine levels, highlighting the prognostic implications of these cytokines.
Clinical • Combination therapy • PD(L)-1 Biomarker • IO biomarker
|
TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10)
|
Keytruda (pembrolizumab) • azacitidine • decitabine • Folotyn (pralatrexate)
2years
Clinical Characteristics, Treatment Patterns, and Outcomes of Cytotoxic Cutaneous T-Cell Lymphomas (ASH 2022)
Treatment data were recorded, including use of radiotherapy (RT), pralatrexate, romidepsin, brentuximab vedotin (BV), combination chemotherapy, allogeneic stem cell transplant (allo-SCT), and others. Given wide variation in disease behavior, treatment intensity should be tailored to each individual's clinical phenotype to optimally balance risk and benefit. Further efforts to define the molecular basis of CCTCLs are urgently needed to aid in the identification of more effective therapies.
Clinical
|
TP53 (Tumor protein P53) • CD8 (cluster of differentiation 8) • TERT (Telomerase Reverse Transcriptase) • JAK1 (Janus Kinase 1) • GZMB (Granzyme B)
|
TP53 mutation
|
Adcetris (brentuximab vedotin) • Istodax (romidepsin) • Folotyn (pralatrexate)
over2years
Palbociclib regulates the expression of dihydrofolate reductase and the cell cycle to inhibit t (11;14) multiple myeloma. (PubMed, Ann Transl Med)
The cell viability and cell cycle were detected to evaluate the anti-myeloma effect of the combination of pralatrexate (PTX) and methotrexate (MTX) with PAL. PAL could promote cell cycle genes and the G1 phase of MM cells. Moreover, PAL reduced the expression level of DHFR and exerted its anticancer effects on t (11;14) MM cells by targeting DHFR.
Journal
|
CDK4 (Cyclin-dependent kinase 4) • MCM2 (Minichromosome maintenance complex component 2) • MCM3 (Minichromosome maintenance complex component 3)
|
Ibrance (palbociclib) • methotrexate • Folotyn (pralatrexate)
over2years
Current Treatment of Peripheral T-cell Lymphoma. (PubMed, Oncology (Williston Park))
In the relapsed or refractory (R/R) setting, we often look to clinical trials or choose from 4 FDA-approved single agents-belinostat, brentuximab vedotin, romidepsin, and pralatrexate-based on tumor phenotype and side-effect profiles. Our goal in the R/R setting is achievement of complete remission followed by allogeneic transplant with curative intent in appropriate candidates or long-term disease control in others. Numerous investigational agents are advancing through trials and have potential to alter standards of care in the near future.
Journal
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 expression
|
Adcetris (brentuximab vedotin) • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
almost3years
BRENTUXIMAB VEDOTIN IN THE TREATMENT OF RELAPSED/REFRACTORY CD30 POSITIVE PERIPHERAL T-CELL LYMPHOMA PATIENTS: A PHASE 2 STUDY OF THE FONDAZIONE ITALIANA LINFOMI (SIE 2021)
Only four agents are FDA-approved for the treatment of R/R PTCL including pralatrexate, romidepsin and belinostat and the objective response rate (ORR) is 25–30% with limited duration of response (DoR) is. The ORR and the OS of in the present study places BV among the active agents for PTCL. Safety concerns emerged about infections, claiming for a strict monitoring for these toxicities.
Clinical • P2 data
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 positive • TNFRSF8 expression
|
Adcetris (brentuximab vedotin) • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
almost3years
Tolinapant (ASTX660), a Non-Peptidomimetic Antagonist of cIAP1/2 and XIAP, and the HDAC Inhibitor Romidepsin Are Synergistic in in Vitro Models of T Cell Lymphoma (ASH 2021)
Tolinapant has demonstrated potent cytotoxic effects against a broad range of TCL lines both as a monotherapy and in combination with the HDAC Inhibitor, romidepsin. In in vitro studies, T cell lymphoma cell lines demonstrated varying sensitivity to tolinapant with certain cell lines being more resistant, even in the presence of TNF alpha. Interestingly, the addition of romidepsin appeared to overcome the intrinsic resistance to tolinapant in the absence of TNF alpha.
Preclinical
|
ALK (Anaplastic lymphoma kinase) • TNFA (Tumor Necrosis Factor-Alpha) • XIAP (X-Linked Inhibitor Of Apoptosis)
|
azacitidine • decitabine • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate) • tolinapant (ASTX660)
3years
An Oncology Simulation Model to Estimate 10-Year Progression-Free Survival and Overall Survival Based on the 5-Year Update from the ECHELON-2 Trial in Frontline Patients with Peripheral T-Cell Lymphoma: A United States Perspective (ASH 2021)
Common frontline (1L) regimens include brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP), and cyclophosphamide, doxorubicin, vincristine, and prednisone with or without the addition of etoposide (CHOP and CHOEP, respectively)...Additional model inputs were derived from: 1) ECHELON-2, with 5-year PFS rates of 51.4% (95% CI 42.8, 59.4) for A+CHP, 43.0% (95% CI 35.8, 50.0) for CHOP, and OS HR 0.72 (95% 0.53, 0.99); 2) published literature to inform PFS for consolidation and subsequent lines of therapy; and 3) expert clinicians’ opinion on commonly used regimens for relapsed/refractory PTCL (included in the model were brentuximab vedotin, romidepsin, pralatrexate, ifosfamide in combination with carboplatin and etoposide [ICE], and gemcitabine-based regimens)...Conclusions The durable and significant improvements in PFS and OS of A+CHP vs CHOP in the 5-year follow-up data from ECHELON-2 estimated an increase in the number of 1L PTCL patients who remain progression free and alive for greater than 10 years. This improvement in outcomes may translate into an increased prevalence of PTCL patients, reflecting an increased number of patients in remission and options to undergo transplant therapy when necessary.
Clinical
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 expression
|
carboplatin • gemcitabine • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • Adcetris (brentuximab vedotin) • vincristine • prednisone • Istodax (romidepsin) • Folotyn (pralatrexate)
3years
Characterization of newly established Pralatrexate-resistant cell lines and the mechanisms of resistance. (PubMed, BMC Cancer)
The resistance mechanisms of PDX were associated with reduced cellular uptake of PDX and/or overexpression of DNMT3B. Epigenetic alterations were also considered to play a role in the resistance mechanism. The combination of DAC and PDX exhibited synergistic activity, and thus, this approach might improve the clinical efficacy of PDX.
Preclinical • Journal
|
DNMT3B (DNA Methyltransferase 3 Beta)
|
decitabine • Folotyn (pralatrexate)
3years
Pembrolizumab and Pralatrexate in Treating Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas (clinicaltrials.gov)
P1/2, N=40, Recruiting, City of Hope Medical Center | Trial completion date: Apr 2021 --> Apr 2023 | Trial primary completion date: Apr 2021 --> Apr 2023
Clinical • Trial completion date • Trial primary completion date
|
ALK (Anaplastic lymphoma kinase)
|
ALK positive • ALK negative
|
Keytruda (pembrolizumab) • Folotyn (pralatrexate)
over3years
A High-Throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma. (PubMed, J Clin Endocrinol Metab)
HTS identified classes of systemic agents which demonstrate preferential effectiveness against aggressive thyroid cancers, particularly those with mutant TP53. Preclinical validation in both orthotopic and PDX models, which are accurate in vivo models mimicking tumor microenvironment, may support initiation of early phase clinical trials in non-BRAF mutated or refractory to BRAF/MEK inhibition ATC.
Journal
|
TP53 (Tumor protein P53)
|
TP53 mutation • BRAF mutation
|
docetaxel • Farydak (panobinostat) • Folotyn (pralatrexate)
over3years
Management of ALCL and other CD30+ peripheral T-cell lymphomas with a focus on Brentuximab vedotin. (PubMed, Semin Hematol)
Peripheral T-cell lymphomas (PTCL) are rare lymphoproliferative disorders with poor outcomes and high rates of relapse. Other treatment options in the relapsed and refractory setting include histone deacetylase inhibitors, pralatrexate, and salvage multiagent chemotherapy regimens. Current research is underway regarding combination therapies and the use of other novel agents.
Journal
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 expression
|
Adcetris (brentuximab vedotin) • Folotyn (pralatrexate)
over3years
Clinical • Enrollment open
|
CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
|
gemcitabine • azacitidine • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
almost4years
Clinical • New P2b trial
|
CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
|
gemcitabine • azacitidine • Istodax (romidepsin) • Beleodaq (belinostat) • Folotyn (pralatrexate)
almost4years
Developing a machine learning model to identify protein-protein interaction hotspots to facilitate drug discovery. (PubMed, PeerJ)
The efficacy of this model has been demonstrated through its successful ability to predict drug-disease associations previously identified in literature, including cimetidine, idarubicin, pralatrexate for these conditions. In addition, nadolol, a beta blocker, has also been identified in this study to bind to the EphB2-ephrinB2 complex, and the possibility of this drug treating multiple cancers is still relatively unexplored.
Journal
|
EPHB2 (EPH Receptor B2)
|
idarubicin hydrochloride • Folotyn (pralatrexate)