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    BIOMARKER:

    FNDC1 overexpression

    i
    Other names: FNDC1, Fibronectin Type III Domain Containing 1, BA243O10.1, DJ322A24.1, KIAA1866, FNDC2, Fibronectin Type III Domain-Containing Protein 1, Fibronectin Type III Domain Containing 2, Expressed In Synovial Lining Protein, Activation-Associated CDNA Protein, MEL4B3, AGS8
    Entrez ID:
    84624
    over2years
    Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation. (PubMed, iScience)
    In this study, we demonstrated that arsenite can efficiently suppress FNDC1 expression, attenuating the formation of the trimers and downstream pathways. Altogether, our results indicate that FNDC1 might be a promising target for clinical treatment and prognostic judgment, while FNDC1 inhibition by arsenite provides a new opportunity for overcoming this fatal disease.
    Journal
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    KDR (Kinase insert domain receptor) • TWIST1 (Twist Family BHLH Transcription Factor 1) • FNDC1 (Fibronectin Type III Domain Containing 1)
    |
    FNDC1 overexpression
    over2years
    The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer. (PubMed, Eur J Histochem)
    In conclusion, FNDC1 promotes the malignant prototypes of NSCLC cells. miR-143-3p is a negative regulator of FNDC1 in NSCLC cells, which may serve as a promising therapeutic target in NSCLC.
    Journal
    |
    FNDC1 (Fibronectin Type III Domain Containing 1) • MIR143 (MicroRNA 143)
    |
    FNDC1 overexpression • miR-143-3p overexpression
    over3years
    Up-regulated FNDC1 accelerates stemness and chemoradiation resistance in colorectal cancer cells. (PubMed, Biochem Biophys Res Commun)
    More importantly, pharmacological inhibition of PI3K/Akt signaling effectively decreased the effect of FNDC1 on chemoradiation resistance. Taken together, our study reveals the potential function of FNDC1 as a biomarker to predict nCRT sensitivity in CRC and a therapeutic target in CRC treatment.
    Journal
    |
    FN1 (Fibronectin 1) • FNDC1 (Fibronectin Type III Domain Containing 1)
    |
    FNDC1 overexpression
    |
    5-fluorouracil