fluoxetine

P=N/A, N=120, Not yet recruiting, The First Affiliated Hospital of Xi'an Jiaotong University; The First Affiliated Hospital of Xi'an Jiaotong University

P=N/A, N=83, Not yet recruiting, The Affiliated Zhongda Hospital of Southeast University; The Affiliated Zhongda Hospital of Southeast University

P1/2, N=520, Recruiting, First Affiliated Hospital of Chongqing Medical University | Trial primary completion date: Dec 2025 --> Dec 2026

Acupuncture alleviates depression-like behaviors in CUMS-induced rats by modulating microglial polarization and inhibiting neuroinflammation-mediated pyroptosis. Our findings provide further evidence supporting acupuncture as a viable strategy for depression treatment.

In summary, fluoxetine has highly significant immunoregulatory effects in patients with MDD and not in controls. Unfortunately, these effects only partly attenuate the immune sensitization in MDD.

Fifty male C57BL/6 mice were randomized into control, model, XLP(2.7, 5.4 mg·g~(-1)), and 5-aminosalicylic acid+fluoxetine groups...Furthermore, XLP lowered the levels of TNF-α, IL-1β, IL-6, and IL-23, down-regulated the transcript levels of IL-6 and IL-23α and the protein level of H3K4me3 while up-regulating the protein level of KDM5B in the cerebral cortical area and the colon tissue, and increased the binding of KDM5B to the IL-6 and IL-23α promoters. XLP may affect H3K4me3 demethylation through KDM5B to reduce the production of inflammatory factors and alleviate the inflammatory response, thus ameliorating UC combined with depression.

Attenuating peripheral serotonin using fluoxetine-a selective serotonin reuptake inhibitor (SSRI) antidepressant-ablates TAM-derived EV delivering of inositol metabolic enzymes and sensitizes tumors to cisplatin/PARP inhibitor (PARPi). Our study unveils a systemic serotonin-primed metabolic crosstalk within the tumor microenvironment that potentiates chemoresistance, revealing targetable HR repair regulation beyond cancer-cell-autonomous mechanisms.

Rats were randomly assigned to control, model, SSa treatment, and fluoxetine-positive control groups...Mechanistically, SSa restored depleted hippocampal 5-HT levels, reduced pro-inflammatory cytokines expression (TNF-α, IL-6, IL-1β), and suppressed NF-κB p65 activation. These findings demonstrate that SSa exerts therapeutic effect against PTSD-like behavior through dual mechanisms: restoration of hippocampal serotonergic neurotransmission and suppression of NF- κB- mediated neuroinflammation, positioning SSa as a promising candidate for PTSD treatment.

P1/2, N=60, Recruiting, Tanta University | Not yet recruiting --> Recruiting

P=N/A, N=296, Recruiting, University of Bern | Active, not recruiting --> Recruiting

P1/2, N=60, Not yet recruiting, Tanta University

Furthermore, reported LDH allosteric inhibitors, including cGmC9 and fluoxetine, preferentially inhibited LDHBtr compared to the native LDHB, by preventing tetramer formation. Overall, this work highlights the central role of tetramerization in regulating LDH activity, and the therapeutic potential of targeting this process. It also establishes LDHBtr as a valuable tool for screening tetramerization disruptors, paving the way for next-generation LDH inhibitors to target cancer metabolism.