fluoxetine

P2, N=3500, Recruiting, National Institute of Mental Health (NIMH) | N=2530 --> 3500

P1/2, N=111, Recruiting, Karolinska University Hospital | Not yet recruiting --> Recruiting

P2, N=240, Recruiting, First Affiliated Hospital of Wenzhou Medical University | Not yet recruiting --> Recruiting

P4, N=180, Recruiting, Poznan University of Medical Sciences

Forty-eight successfully modeled rats were randomly divided into a model group, an acupuncture group, a fluoxetine group, and an acupuncture+agonist group, with 12 rats in each group...Compared with the acupuncture+agonist group, the acupuncture group showed better improvement in all indexes (P<0.05). Tongdu Tiaoshen acupuncture could improve neurological function and depressive-like behavior in PSD rats, possibly by inhibiting the CCL2-CCR2 pathway and promoting neuronal synaptic remodeling in the hippocampus.

Obtained data confirm the inhibitory effect of fluoxetine on melanoma growth, but only when this antidepressant is given to animals that already struggle with melanoma development. Fluoxetine administration before cancer development accelerates its progress and induces unbeneficial changes in immunity and metalloproteinase levels in comparison to saline-pretreated mice.

Mice exhibiting PTSD-like behaviour were treated with fluoxetine (FLU, 10 mg/kg), an antidepressant drug, and COR (10 and 50 mg/kg). COR demonstrated a dose-dependent response with 50 mg/kg showing consistent improvement in both behavioural and biochemical parameters. Overall, COR exhibited promising activity in this model and may serve as a potential natural therapeutic strategy to investigate for the management of PTSD in clinics.

P=N/A, N=80, Not yet recruiting, University of Oxford

SIGNIFICANCE STATEMENT: Fluoxetine, an US Food and Drug Administration-approved selective serotonin reuptake inhibitor reduces solid tumor (breast and melanoma) load through immune mediated tumor cell death and restore antitumor immunity. It remodels tumor microenvironment, activates T cells, reduces cancer stemness and metastasis via regulation of epithelial mesenchymal transition factors, hypoxia Inducible factor 1α, and β-catenin.

SEO exerts antidepressant-like effects in BCRD by modulating hippocampus-centered metabolic and functional networks. Eugenol and 2-phenylethanol were identified as key brain-entry components to function through metabolic pathways. ALOX15 inhibition and CAII improvement were proven to be the main molecular mechanisms. These findings provide mechanistic insights and identify SEO as a promising plant-derived therapeutic candidate for managing cancer-related depression.

P=N/A, N=80, Recruiting, University of Oxford

P=N/A, N=50, Recruiting, Minia University