^
    2d
    Efficacy of Topical 5-Fluorouracil Vs Calcipotriol As Photodynamic Therapy Pre-treatment for Field Actinic Keratoses (clinicaltrials.gov)
    P=N/A, N=50, Not yet recruiting, St Vincent's University Hospital, Ireland
    New trial
    |
    fluorouracil topical
    8d
    CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type, Metastatic Colorectal Cancer (clinicaltrials.gov)
    P3, N=520, Completed, Taizhou Mabtech Pharmaceutical Co.,Ltd | Active, not recruiting --> Completed
    Trial completion • Metastases
    |
    BRAF (B-raf proto-oncogene) • RAS (Rat Sarcoma Virus)
    |
    BRAF wild-type
    |
    irinotecan • leucovorin calcium • fluorouracil topical • Enlituo (cetuximab biosimilar)
    9d
    NRG-HN001: Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA (clinicaltrials.gov)
    P2/3, N=685, Active, not recruiting, NRG Oncology | Phase classification: P3 --> P2/3
    Phase classification
    |
    cisplatin • gemcitabine • paclitaxel • fluorouracil topical
    28d
    Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer (clinicaltrials.gov)
    P3, N=3610, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Sep 2024 --> Dec 2024 | Trial primary completion date: Sep 2024 --> Dec 2024
    Trial completion date • Trial primary completion date • Surgery
    |
    MSI (Microsatellite instability) • MSH2 (MutS Homolog 2)
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • fluorouracil topical
    1m
    Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery (clinicaltrials.gov)
    P3, N=537, Active, not recruiting, Children's Oncology Group | Phase classification: P2/3 --> P3
    Phase classification • Surgery
    |
    SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein)
    |
    AFP elevation
    |
    cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine • daunorubicin • fluorouracil topical
    1m
    OPTIMA-II: Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer (clinicaltrials.gov)
    P2, N=76, Completed, University of Chicago | Active, not recruiting --> Completed
    Trial completion • Surgery • Metastases
    |
    Opdivo (nivolumab) • cisplatin • carboplatin • albumin-bound paclitaxel • hydroxyurea • fluorouracil topical
    1m
    Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma (clinicaltrials.gov)
    P2, N=40, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2024 --> Dec 2026 | Trial primary completion date: Dec 2024 --> Dec 2026
    Trial completion date • Trial primary completion date • Surgery
    |
    PD-L1 (Programmed death ligand 1)
    |
    Tecentriq (atezolizumab) • oxaliplatin • tiragolumab (RG6058) • fluorouracil topical
    2ms
    Zimberelimab and Quemliclustat in Combination with Chemotherapy for the Treatment of Patients with Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma (clinicaltrials.gov)
    P1/2, N=56, Recruiting, Jonsson Comprehensive Cancer Center | Suspended --> Recruiting
    Enrollment open
    |
    oxaliplatin • irinotecan • Yutuo (zimberelimab) • leucovorin calcium • fluorouracil topical • quemliclustat (AB680)
    2ms
    Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant (clinicaltrials.gov)
    P2, N=46, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025
    Trial completion date • Trial primary completion date • Metastases
    |
    MUC16 (Mucin 16, Cell Surface Associated)
    |
    cisplatin • gemcitabine • leucovorin calcium • fluorouracil topical
    2ms
    NCI-2015-00693: Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination with Multiple Standard Chemotherapy or Immunotherapy Agents in Patients with Advanced Malignancies (clinicaltrials.gov)
    P1, N=221, Terminated, M.D. Anderson Cancer Center | Trial completion date: Dec 2024 --> Sep 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2024 --> Sep 2024; Administratively Complete
    Trial completion date • Trial termination • Trial primary completion date • Combination therapy • IO biomarker • Metastases
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • Lynparza (olaparib) • Yervoy (ipilimumab) • carboplatin • paclitaxel • doxorubicin hydrochloride • capecitabine • cyclophosphamide • pemetrexed • oxaliplatin • irinotecan • Halaven (eribulin mesylate) • Xpovio (selinexor) • daunorubicin • topotecan • leucovorin calcium • fluorouracil topical • Pemfexy (pemetrexed)
    2ms
    OPTIMA-II: Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer (clinicaltrials.gov)
    P2, N=76, Active, not recruiting, University of Chicago | Trial completion date: Jul 2025 --> Sep 2024 | Trial primary completion date: Jul 2025 --> Sep 2024
    Trial completion date • Trial primary completion date • Surgery • Metastases
    |
    Opdivo (nivolumab) • cisplatin • carboplatin • albumin-bound paclitaxel • hydroxyurea • fluorouracil topical
    3ms
    LAPIS: Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Participants With Locally Advanced Pancreatic Cancer (clinicaltrials.gov)
    P3, N=284, Completed, FibroGen | Active, not recruiting --> Completed
    Trial completion • Combination therapy • Metastases
    |
    gemcitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical • pamrevlumab (FG-3019)
    3ms
    Nivolumab in Combination With Chemotherapy Pre-Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer (clinicaltrials.gov)
    P1, N=28, Completed, Jonsson Comprehensive Cancer Center | Active, not recruiting --> Completed | Trial completion date: Apr 2026 --> May 2024 | Trial primary completion date: Apr 2025 --> May 2024
    Trial completion • Trial completion date • Trial primary completion date • Combination therapy • Surgery • Pre-surgery
    |
    IFNG (Interferon, gamma)
    |
    Opdivo (nivolumab) • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    3ms
    Pembrolizumab and Chemoradiotherapy for the Treatment of Unresectable Gastroesophageal Cancer (clinicaltrials.gov)
    P1, N=16, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Jul 2024 --> Jul 2025
    Trial completion date • Trial primary completion date • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    Keytruda (pembrolizumab) • docetaxel • oxaliplatin • fluorouracil topical
    3ms
    FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer (clinicaltrials.gov)
    P1/2, N=86, Recruiting, City of Hope Medical Center | Trial completion date: Apr 2025 --> Oct 2025 | Trial primary completion date: Apr 2025 --> Oct 2025
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    POLE (DNA Polymerase Epsilon)
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • balstilimab (AGEN2034) • botensilimab (AGEN1181) • fluorouracil topical
    3ms
    Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P2, N=25, Not yet recruiting, Mayo Clinic | Trial completion date: Jul 2029 --> Oct 2029 | Initiation date: Jun 2024 --> Oct 2024 | Trial primary completion date: Jul 2029 --> Oct 2029
    Trial completion date • Trial initiation date • Trial primary completion date • Metastases
    |
    Keytruda (pembrolizumab) • oxaliplatin • irinotecan • leucovorin calcium • Visudyne (verteporfin) • fluorouracil topical
    4ms
    Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo (clinicaltrials.gov)
    P4, N=60, Recruiting, Al-Azhar University | Trial completion date: Apr 2024 --> Oct 2024 | Trial primary completion date: Apr 2024 --> Oct 2024
    Trial completion date • Trial primary completion date
    |
    fluorouracil topical
    4ms
    PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer (clinicaltrials.gov)
    P1, N=49, Recruiting, City of Hope Medical Center | Trial completion date: Dec 2025 --> Aug 2026 | Trial primary completion date: Dec 2025 --> Aug 2026
    Trial completion date • Trial primary completion date
    |
    cisplatin • doxorubicin hydrochloride • oxaliplatin • irinotecan • daunorubicin • leucovorin calcium • Jelmyto (mitomycin urothelial gel) • fluorouracil topical
    5ms
    Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions (clinicaltrials.gov)
    P3, N=91, Completed, AIDS Malignancy Consortium | Active, not recruiting --> Completed
    Trial completion
    |
    Zyclara (imiquimod) • fluorouracil topical
    5ms
    Safety and adherence to self-administered intravaginal 5-fluorouracil cream following cervical intraepithelial neoplasia (CIN) 2/3 treatment among HIV-positive women in Kenya: A phase 1 clinical trial. (PubMed, medRxiv)
    Randomized trials are needed to investigate whether adjuvant 5FU can improve treatment outcomes or serve as primary cervical precancer treatment in sub-Saharan Africa. A self-administered therapy may be transformative in increasing access to treatment and, hence, secondary prevention of cervical cancer.
    P1 data • Journal • Adherence
    |
    CD4 (CD4 Molecule)
    |
    fluorouracil topical
    6ms
    Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov)
    P2, N=128, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025
    Trial completion date • Trial primary completion date • Metastases
    |
    Erbitux (cetuximab) • cisplatin • carboplatin • paclitaxel • docetaxel • fluorouracil topical
    6ms
    SHIELD-RT: Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer (clinicaltrials.gov)
    P3, N=475, Active, not recruiting, National Cancer Institute (NCI) | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    PD-L1 (Programmed death ligand 1) • CD4 (CD4 Molecule)
    |
    cisplatin • Tecentriq (atezolizumab) • gemcitabine • Jelmyto (mitomycin urothelial gel) • fluorouracil topical
    6ms
    NCI-2018-01810: Docetaxel, Cisplatin and Fluorouracil in Treating Patients With Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer (clinicaltrials.gov)
    P2, N=31, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Sep 2024 --> Sep 2025 | Trial primary completion date: Sep 2024 --> Sep 2025
    Trial completion date • Trial primary completion date • Metastases
    |
    cisplatin • carboplatin • docetaxel • fluorouracil topical
    6ms
    Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients (clinicaltrials.gov)
    P2, N=56, Recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2027 --> Feb 2029
    Trial completion date
    |
    CD4 (CD4 Molecule) • ITGAE (Integrin Subunit Alpha E) • TSLP (Thymic Stromal Lymphopoietin)
    |
    fluorouracil topical
    6ms
    Nivolumab in Combination With Chemotherapy Pre-Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer (clinicaltrials.gov)
    P1, N=28, Active, not recruiting, Jonsson Comprehensive Cancer Center | Recruiting --> Active, not recruiting | Trial completion date: Apr 2025 --> Apr 2026 | Trial primary completion date: Apr 2024 --> Apr 2025
    Enrollment closed • Trial completion date • Trial primary completion date • Combination therapy • Surgery • Pre-surgery
    |
    IFNG (Interferon, gamma)
    |
    IFNG-L
    |
    Opdivo (nivolumab) • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    7ms
    Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer (clinicaltrials.gov)
    P1, N=3, Terminated, National Cancer Institute (NCI) | Active, not recruiting --> Terminated; Due to Covid and poor enrollment
    Trial termination • Surgery • Metastases
    |
    capecitabine • oxaliplatin • leucovorin calcium • Imlygic (talimogene laherparepvec) • fluorouracil topical
    7ms
    Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines (clinicaltrials.gov)
    P1, N=10, Active, not recruiting, National Cancer Institute (NCI) | N=90 --> 10 | Trial completion date: Dec 2024 --> Apr 2025 | Trial primary completion date: Dec 2024 --> Mar 2024
    Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    irinotecan • elimusertib (BAY 1895344) • leucovorin calcium • fluorouracil topical
    7ms
    Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P2, N=25, Not yet recruiting, Mayo Clinic
    New P2 trial • Metastases
    |
    Keytruda (pembrolizumab) • oxaliplatin • irinotecan • leucovorin calcium • Visudyne (verteporfin) • fluorouracil topical
    7ms
    Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial (clinicaltrials.gov)
    P3, N=408, Recruiting, ECOG-ACRIN Cancer Research Group | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Avastin (bevacizumab) • Erbitux (cetuximab) • Vectibix (panitumumab) • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    7ms
    Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery (clinicaltrials.gov)
    P1/2, N=31, Completed, Mayo Clinic | Active, not recruiting --> Completed | Trial completion date: May 2024 --> Oct 2023
    Trial completion • Trial completion date • Surgery • Metastases
    |
    Keytruda (pembrolizumab) • carboplatin • paclitaxel • oxaliplatin • leucovorin calcium • fluorouracil topical
    7ms
    Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery (clinicaltrials.gov)
    P1/2, N=31, Active, not recruiting, Mayo Clinic | Phase classification: P1b/2 --> P1/2
    Phase classification • Surgery • Metastases
    |
    Keytruda (pembrolizumab) • carboplatin • paclitaxel • oxaliplatin • leucovorin calcium • fluorouracil topical
    7ms
    Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients (clinicaltrials.gov)
    P2, N=56, Recruiting, National Cancer Institute (NCI) | Not yet recruiting --> Recruiting
    Enrollment open
    |
    CD4 (CD4 Molecule) • ITGAE (Integrin Subunit Alpha E) • TSLP (Thymic Stromal Lymphopoietin)
    |
    fluorouracil topical
    7ms
    ACT2: Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV (clinicaltrials.gov)
    P=N/A, N=180, Recruiting, UNC Lineberger Comprehensive Cancer Center | Trial completion date: May 2025 --> Dec 2025 | Trial primary completion date: May 2025 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    fluorouracil topical
    7ms
    NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer (clinicaltrials.gov)
    P2, N=60, Recruiting, OHSU Knight Cancer Institute | Trial primary completion date: Apr 2024 --> Apr 2025
    Trial primary completion date • Surgery • Metastases
    |
    CA 19-9 (Cancer antigen 19-9)
    |
    gemcitabine • capecitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    7ms
    Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer (clinicaltrials.gov)
    P3, N=3610, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2024 --> Sep 2024 | Trial primary completion date: Mar 2024 --> Sep 2024
    Trial completion date • Trial primary completion date • Surgery
    |
    MSI (Microsatellite instability) • MSH2 (MutS Homolog 2)
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • fluorouracil topical
    7ms
    CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type, Metastatic Colorectal Cancer (clinicaltrials.gov)
    P3, N=520, Active, not recruiting, Taizhou Mabtech Pharmaceutical Co.,Ltd | Trial completion date: Jun 2023 --> Jun 2024
    Trial completion date • Metastases
    |
    BRAF (B-raf proto-oncogene) • RAS (Rat Sarcoma Virus)
    |
    BRAF wild-type
    |
    irinotecan • leucovorin calcium • fluorouracil topical • Enlituo (cetuximab biosimilar)
    7ms
    Recurrence of Odontogenic Keratocyst (clinicaltrials.gov)
    P=N/A, N=48, Enrolling by invitation, Tanta University | Trial completion date: Dec 2023 --> Jun 2024
    Trial completion date
    |
    fluorouracil topical
    7ms
    S1513: FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P2, N=123, Active, not recruiting, National Cancer Institute (NCI)
    Trial completion date • Metastases
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • CEACAM5 (CEA Cell Adhesion Molecule 5)
    |
    BRCA2 mutation • BRCA1 mutation • HRD • HRD + BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
    |
    irinotecan • veliparib (ABT-888) • leucovorin calcium • fluorouracil topical
    7ms
    Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair (clinicaltrials.gov)
    P3, N=700, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Apr 2024 --> Apr 2025 | Trial primary completion date: Apr 2024 --> Apr 2025
    Trial completion date • Trial primary completion date • Mismatch repair • Tumor mutational burden
    |
    MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • CD4 (CD4 Molecule)
    |
    MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PMS2 mutation • MSH6 expression
    |
    Tecentriq (atezolizumab) • oxaliplatin • leucovorin calcium • fluorouracil topical
    7ms
    Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer (clinicaltrials.gov)
    P3, N=236, Active, not recruiting, National Cancer Institute (NCI)
    Trial completion date
    |
    AFP (Alpha-fetoprotein)
    |
    AFP elevation
    |
    cisplatin • doxorubicin hydrochloride • irinotecan • Torisel (temsirolimus) • vincristine • fluorouracil topical • dexrazoxane
    8ms
    Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer (clinicaltrials.gov)
    P1, N=24, Recruiting, Arjun Mittra | Not yet recruiting --> Recruiting
    Enrollment open
    |
    oxaliplatin • fluorouracil topical
    8ms
    Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer (clinicaltrials.gov)
    P1/2, N=120, Recruiting, Flemming Forsberg | Trial primary completion date: Jun 2024 --> Dec 2024
    Trial primary completion date
    |
    gemcitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical