^
    15h
    Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer (clinicaltrials.gov)
    P1, N=3, Terminated, National Cancer Institute (NCI) | Active, not recruiting --> Terminated; Due to Covid and poor enrollment
    Trial termination • Surgery • Metastases
    |
    capecitabine • oxaliplatin • leucovorin calcium • Imlygic (talimogene laherparepvec) • fluorouracil topical
    15h
    Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines (clinicaltrials.gov)
    P1, N=10, Active, not recruiting, National Cancer Institute (NCI) | N=90 --> 10 | Trial completion date: Dec 2024 --> Apr 2025 | Trial primary completion date: Dec 2024 --> Mar 2024
    Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    irinotecan • elimusertib (BAY 1895344) • leucovorin calcium • fluorouracil topical
    8d
    Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P2, N=25, Not yet recruiting, Mayo Clinic
    New P2 trial • Metastases
    |
    Keytruda (pembrolizumab) • oxaliplatin • irinotecan • leucovorin calcium • Visudyne (verteporfin) • fluorouracil topical
    10d
    Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial (clinicaltrials.gov)
    P3, N=408, Recruiting, ECOG-ACRIN Cancer Research Group | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Avastin (bevacizumab) • Erbitux (cetuximab) • Vectibix (panitumumab) • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    14d
    Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery (clinicaltrials.gov)
    P1/2, N=31, Completed, Mayo Clinic | Active, not recruiting --> Completed | Trial completion date: May 2024 --> Oct 2023
    Trial completion • Trial completion date • Surgery • Metastases
    |
    Keytruda (pembrolizumab) • carboplatin • paclitaxel • oxaliplatin • leucovorin calcium • fluorouracil topical
    15d
    Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery (clinicaltrials.gov)
    P1/2, N=31, Active, not recruiting, Mayo Clinic | Phase classification: P1b/2 --> P1/2
    Phase classification • Surgery • Metastases
    |
    Keytruda (pembrolizumab) • carboplatin • paclitaxel • oxaliplatin • leucovorin calcium • fluorouracil topical
    16d
    Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients (clinicaltrials.gov)
    P2, N=56, Recruiting, National Cancer Institute (NCI) | Not yet recruiting --> Recruiting
    Enrollment open
    |
    CD4 (CD4 Molecule) • ITGAE (Integrin Subunit Alpha E) • TSLP (Thymic Stromal Lymphopoietin)
    |
    fluorouracil topical
    17d
    ACT2: Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV (clinicaltrials.gov)
    P=N/A, N=180, Recruiting, UNC Lineberger Comprehensive Cancer Center | Trial completion date: May 2025 --> Dec 2025 | Trial primary completion date: May 2025 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    fluorouracil topical
    20d
    NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer (clinicaltrials.gov)
    P2, N=60, Recruiting, OHSU Knight Cancer Institute | Trial primary completion date: Apr 2024 --> Apr 2025
    Trial primary completion date • Surgery • Metastases
    |
    CA 19-9 (Cancer antigen 19-9)
    |
    gemcitabine • capecitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    21d
    Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer (clinicaltrials.gov)
    P3, N=3610, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2024 --> Sep 2024 | Trial primary completion date: Mar 2024 --> Sep 2024
    Trial completion date • Trial primary completion date • Surgery
    |
    MSI (Microsatellite instability) • MSH2 (MutS Homolog 2)
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • fluorouracil topical
    22d
    CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type, Metastatic Colorectal Cancer (clinicaltrials.gov)
    P3, N=520, Active, not recruiting, Taizhou Mabtech Pharmaceutical Co.,Ltd | Trial completion date: Jun 2023 --> Jun 2024
    Trial completion date • Metastases
    |
    BRAF (B-raf proto-oncogene) • RAS (Rat Sarcoma Virus)
    |
    BRAF wild-type
    |
    irinotecan • leucovorin calcium • fluorouracil topical • Enlituo (cetuximab biosimilar)
    22d
    Recurrence of Odontogenic Keratocyst (clinicaltrials.gov)
    P=N/A, N=48, Enrolling by invitation, Tanta University | Trial completion date: Dec 2023 --> Jun 2024
    Trial completion date
    |
    fluorouracil topical
    27d
    S1513: FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P2, N=123, Active, not recruiting, National Cancer Institute (NCI)
    Trial completion date • Metastases
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • CEACAM5 (CEA Cell Adhesion Molecule 5)
    |
    BRCA2 mutation • BRCA1 mutation • HRD • HRD + BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
    |
    irinotecan • veliparib (ABT-888) • leucovorin calcium • fluorouracil topical
    27d
    Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair (clinicaltrials.gov)
    P3, N=700, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Apr 2024 --> Apr 2025 | Trial primary completion date: Apr 2024 --> Apr 2025
    Trial completion date • Trial primary completion date • Mismatch repair • Tumor mutational burden
    |
    MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • CD4 (CD4 Molecule)
    |
    MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PMS2 mutation • MSH6 expression
    |
    Tecentriq (atezolizumab) • oxaliplatin • leucovorin calcium • fluorouracil topical
    27d
    Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer (clinicaltrials.gov)
    P3, N=236, Active, not recruiting, National Cancer Institute (NCI)
    Trial completion date
    |
    AFP (Alpha-fetoprotein)
    |
    AFP elevation
    |
    cisplatin • doxorubicin hydrochloride • irinotecan • Torisel (temsirolimus) • vincristine • fluorouracil topical • dexrazoxane
    1m
    Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer (clinicaltrials.gov)
    P1, N=24, Recruiting, Arjun Mittra | Not yet recruiting --> Recruiting
    Enrollment open
    |
    oxaliplatin • fluorouracil topical
    2ms
    Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer (clinicaltrials.gov)
    P1/2, N=120, Recruiting, Flemming Forsberg | Trial primary completion date: Jun 2024 --> Dec 2024
    Trial primary completion date
    |
    gemcitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    2ms
    Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov)
    P3, N=403, Active, not recruiting, National Cancer Institute (NCI)
    Trial completion date • Metastases
    |
    Avastin (bevacizumab) • cisplatin • carboplatin • docetaxel • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • fluorouracil topical
    2ms
    Atypical Fibroxanthoma Treated with a Topical Combination of Imiquimod, Tazarotene, and 5-Fluorouracil. (PubMed, Dermatol Ther (Heidelb))
    This topical regimen consisted of tazarotene cream, imiquimod cream, and 5-fluorouracil solution, applied for 30 days. This case marks the first recorded instance of successful topical medical treatment of AFX, offering an alternative for patients who may opt out of surgical intervention. Continued research to assess the broader efficacy of this approach is encouraged.
    Journal
    |
    MME (Membrane Metalloendopeptidase) • CD99 (CD99 Molecule)
    |
    5-fluorouracil • Zyclara (imiquimod) • fluorouracil topical
    2ms
    Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial (clinicaltrials.gov)
    P1, N=2, Terminated, OHSU Knight Cancer Institute | Active, not recruiting --> Terminated; Low accrual
    Trial termination
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • Avastin (bevacizumab) • Venclexta (venetoclax) • Lynparza (olaparib) • Mekinist (trametinib) • erlotinib • Gilotrif (afatinib) • Yervoy (ipilimumab) • Ibrance (palbociclib) • dasatinib • Zelboraf (vemurafenib) • Tafinlar (dabrafenib) • carboplatin • Imfinzi (durvalumab) • sorafenib • Rozlytrek (entrectinib) • imatinib • Sutent (sunitinib) • everolimus • Nerlynx (neratinib) • Iclusig (ponatinib) • Kadcyla (ado-trastuzumab emtansine) • Cotellic (cobimetinib) • Lorbrena (lorlatinib) • Lenvima (lenvatinib) • bortezomib • doxorubicin hydrochloride • capecitabine • Verzenio (abemaciclib) • Xtandi (enzalutamide capsule) • Cabometyx (cabozantinib tablet) • albumin-bound paclitaxel • Stivarga (regorafenib) • abiraterone acetate • oxaliplatin • Aliqopa (copanlisib) • Vizimpro (dacomitinib) • Zydelig (idelalisib) • daunorubicin • Zolinza (vorinostat) • Idhifa (enasidenib) • Farydak (panobinostat) • Erivedge (vismodegib) • Nubeqa (darolutamide) • bicalutamide • leucovorin calcium • cabazitaxel • Vesanoid (tretinoin) • fluorouracil topical
    2ms
    Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery (clinicaltrials.gov)
    P3, N=548, Active, not recruiting, National Cancer Institute (NCI) | Phase classification: P2/3 --> P3
    Phase classification
    |
    erlotinib • gemcitabine • capecitabine • fluorouracil topical
    2ms
    LAPIS: Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Participants With Locally Advanced Pancreatic Cancer (clinicaltrials.gov)
    P3, N=284, Active, not recruiting, FibroGen | Trial completion date: Dec 2023 --> Apr 2024 | Trial primary completion date: Dec 2023 --> Apr 2024
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    gemcitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical • pamrevlumab (FG-3019)
    2ms
    Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer (clinicaltrials.gov)
    P1, N=24, Not yet recruiting, Arjun Mittra
    New P1 trial
    |
    oxaliplatin • fluorouracil topical
    3ms
    Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer (clinicaltrials.gov)
    P2, N=240, Recruiting, National Cancer Institute (NCI) | Initiation date: Jun 2024 --> Dec 2023
    Trial initiation date
    |
    MSI (Microsatellite instability) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2)
    |
    MSI-H/dMMR • MSH6 expression
    |
    Tecentriq (atezolizumab) • docetaxel • capecitabine • oxaliplatin • leucovorin calcium • fluorouracil topical
    3ms
    Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma (clinicaltrials.gov)
    P1/2, N=56, Suspended, Jonsson Comprehensive Cancer Center | Recruiting --> Suspended
    Trial suspension • Combination therapy • Metastases
    |
    oxaliplatin • irinotecan • Yutuo (zimberelimab) • leucovorin calcium • fluorouracil topical • quemliclustat (AB680)
    3ms
    Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer (clinicaltrials.gov)
    P1/2, N=15, Suspended, M.D. Anderson Cancer Center | Active, not recruiting --> Suspended
    Trial suspension
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    Opdivo (nivolumab) • fluorouracil topical • Novaferon (recombinant anti-tumor and anti-virus protein)
    3ms
    Pembrolizumab and Chemoradiotherapy for the Treatment of Unresectable Gastroesophageal Cancer (clinicaltrials.gov)
    P1, N=15, Active, not recruiting, M.D. Anderson Cancer Center | Recruiting --> Active, not recruiting | Trial completion date: Jan 2024 --> Jul 2024 | Trial primary completion date: Jan 2024 --> Jul 2024
    Enrollment closed • Trial completion date • Trial primary completion date • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    Keytruda (pembrolizumab) • docetaxel • oxaliplatin • fluorouracil topical
    3ms
    COBRA: Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery (clinicaltrials.gov)
    P2/3, N=1408, Active, not recruiting, NRG Oncology | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    capecitabine • oxaliplatin • leucovorin calcium • fluorouracil topical
    3ms
    Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery (clinicaltrials.gov)
    P2/3, N=546, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Jan 2025
    Trial completion date • Surgery
    |
    erlotinib • gemcitabine • capecitabine • fluorouracil topical
    3ms
    PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer (clinicaltrials.gov)
    P1, N=49, Recruiting, City of Hope Medical Center | Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    cisplatin • doxorubicin hydrochloride • oxaliplatin • irinotecan • daunorubicin • leucovorin calcium • Jelmyto (mitomycin urothelial gel) • fluorouracil topical
    3ms
    Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery (clinicaltrials.gov)
    P2/3, N=537, Active, not recruiting, Children's Oncology Group | Recruiting --> Active, not recruiting
    Enrollment closed • Surgery
    |
    SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • AFP (Alpha-fetoprotein)
    |
    AFP elevation
    |
    cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine • daunorubicin • fluorouracil topical
    3ms
    ANCHOR: Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions (clinicaltrials.gov)
    P3, N=4446, Active, not recruiting, AIDS Malignancy Consortium | Trial completion date: Sep 2024 --> Mar 2024
    Trial completion date • HEOR
    |
    Zyclara (imiquimod) • fluorouracil topical
    4ms
    Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients (clinicaltrials.gov)
    P2, N=56, Not yet recruiting, National Cancer Institute (NCI) | Phase classification: P2a --> P2 | Trial completion date: Nov 2026 --> Feb 2027 | Initiation date: Nov 2023 --> Feb 2024 | Trial primary completion date: Nov 2026 --> Feb 2027
    Phase classification • Trial completion date • Trial initiation date • Trial primary completion date
    |
    CD4 (CD4 Molecule) • ITGAE (Integrin Subunit Alpha E) • TSLP (Thymic Stromal Lymphopoietin)
    |
    fluorouracil topical
    4ms
    Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer (clinicaltrials.gov)
    P2, N=44, Recruiting, University of Nebraska | Trial completion date: Dec 2024 --> Dec 2027 | Trial primary completion date: Dec 2024 --> Dec 2027
    Trial completion date • Trial primary completion date • Metastases
    |
    capecitabine • zoledronic acid • fluorouracil topical
    4ms
    Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer (clinicaltrials.gov)
    P1/2, N=15, Active, not recruiting, M.D. Anderson Cancer Center | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    Opdivo (nivolumab) • fluorouracil topical • Novaferon (recombinant anti-tumor and anti-virus protein)
    4ms
    5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer (clinicaltrials.gov)
    P2/3, N=200, Recruiting, Boston University
    Trial completion date • Trial primary completion date
    |
    fluorouracil topical
    4ms
    Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines (clinicaltrials.gov)
    P1, N=90, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    irinotecan • elimusertib (BAY 1895344) • leucovorin calcium • fluorouracil topical
    4ms
    Short-Course Chemoradiotherapy Followed by Chemotherapy for the Treatment of Resectable Gastric Adenocarcinoma (clinicaltrials.gov)
    P1, N=25, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2027 --> Dec 2028 | Trial primary completion date: Dec 2027 --> Dec 2028
    Trial completion date • Trial primary completion date
    |
    capecitabine • fluorouracil topical
    4ms
    Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer (clinicaltrials.gov)
    P3, N=3610, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Mar 2024 | Trial primary completion date: Dec 2023 --> Mar 2024
    Trial completion date • Trial primary completion date • Surgery
    |
    MSI (Microsatellite instability) • MSH2 (MutS Homolog 2)
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • fluorouracil topical
    4ms
    GIANT: Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread (clinicaltrials.gov)
    P2, N=176, Active, not recruiting, ECOG-ACRIN Cancer Research Group | Recruiting --> Active, not recruiting | Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2025
    Enrollment closed • Trial completion date • Trial primary completion date • Metastases
    |
    IL6 (Interleukin 6) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
    |
    UGT1A1*1*1
    |
    gemcitabine • albumin-bound paclitaxel • leucovorin calcium • Onivyde (nanoliposomal irinotecan) • fluorouracil topical
    5ms
    Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery (clinicaltrials.gov)
    P2/3, N=545, Active, not recruiting, National Cancer Institute (NCI) | Phase classification: P3 --> P2/3
    Phase classification • Surgery
    |
    erlotinib • gemcitabine • capecitabine • fluorouracil topical
    5ms
    2 Versus 6 Hour Oxaliplatin Infusions in Patients With Gastrointestinal Cancers (clinicaltrials.gov)
    P2, N=60, Recruiting, Emory University | Trial completion date: Mar 2024 --> Nov 2024 | Trial primary completion date: Nov 2023 --> Nov 2024
    Trial completion date • Trial primary completion date
    |
    oxaliplatin • leucovorin calcium • fluorouracil topical