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    BIOMARKER:

    FLT4 amplification

    i
    Other names: FLT4, PCL, VEGFR3, Fms-related tyrosine kinase 4
    Entrez ID:
    2324
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    almost2years
    Characterization of DICER1 Mutations in Clinically Aggressive Thyroid Carcinomas from a Large Database of Real-World Patient Samples (USCAP 2023)
    DICER1 MT thyroid cancers make up a fraction of advanced stage, clinically aggressive thyroid cancers. Here, we found that they are most common in middle age to older adults even though prior studies have shown that DICER1 mutations account for most adolescent PDTCs and are present in a much larger percentage of pediatric thyroid nodules overall compared to adult nodules. We speculate that a small subset of indolent pediatric DICER1 MT thyroid tumors develop additional mutations leading to more aggressive behavior, and that this tumor progression occurs later in life.
    Clinical • Real-world evidence • Real-world
    |
    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • NRAS (Neuroblastoma RAS viral oncogene homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CHEK2 (Checkpoint kinase 2) • FLT4 (Fms-related tyrosine kinase 4) • DICER1 (Dicer 1 Ribonuclease III)
    |
    TP53 mutation • KRAS mutation • CHEK2 mutation • FLT4 amplification • TP53 amplification
    4years
    MYC gene amplification by fluorescence in situ hybridization and MYC protein expression by immunohistochemistry in the diagnosis of cutaneous angiosarcoma: systematic review and appropriate use criteria. (PubMed, J Cutan Pathol)
    FISH for MYC amplification and IHC for MYC overexpression are useful in distinguishing PRAS from AVLs and may also have prognostic value in secondary AS. In contrast, these methods have little diagnostic or prognostic value in primary AS and should not be used to distinguish primary AS from benign vascular neoplasms.
    Review • Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • FLT4 (Fms-related tyrosine kinase 4)
    |
    MYC amplification • MYC overexpression • MYC expression • FLT4 amplification