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GENE:

FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

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27d

Genetic and Epigenetic Mechanisms in Serrated Adenocarcinomas and Classical Colorectal Carcinomas: An In Silico Study. (PubMed, Curr Issues Mol Biol)

The hub genes act as molecular bridges connecting the observed genomic and epigenetic variations, particularly driving chromatin-related regulation and MAPK signaling pathways. In particular, PSMC1, SNW1, H3C2, H1-2, and H2BC14 genes offer promising molecular targets for future therapeutic approaches in SACs.

27 days ago

Journal

FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • H3C1 (H3 Clustered Histone 1) • MYOD1 (Myogenic Differentiation 1) • PSMC1 (Proteasome 26S Subunit, ATPase 1)

A Two-way Mendelian randomisation study of inflammatory factors and the risk of meningioma. (PubMed, Transl Neurosci)

This study clarified FLT3 as being involved in the pathogenesis of meningioma from a genetic perspective and genetically predicted lower FLT3L to be causally associated with a higher meningioma risk, implicating FLT3 signalling in meningioma pathogenesis. FLT3 as a genetically supported candidate factor associated with meningioma risk.

1 month ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • CCL19 (C-C Motif Chemokine Ligand 19) • IL5 (Interleukin 5) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)

Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes. (PubMed, Nat Immunol)

The combination of Flt3L and anti-CTLA-4 enhanced therapeutic responses. Combination therapy is associated with the emergence of a CD8+ T cell subset characterized by the expression of Il21r and oligoclonal expansion of CD8+ T cells within tumors through a mechanism that is dependent on lymph node egress.

1 month ago

Journal • IO biomarker

FLT3 (Fms-related tyrosine kinase 3) • CD8 (cluster of differentiation 8) • SLAMF6 (SLAM Family Member 6) • IL1R1 (Interleukin 1 receptor, type I) • IL21R (Interleukin 21 Receptor) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

5ms

Circulating inflammatory proteins and osteomyelitis: A bidirectional Mendelian randomization and colocalization analysis. (PubMed, Medicine (Baltimore))

This study identified several CIPs - including TNF-β, osteoprotegerin, and adenosine deaminase - as potentially causal in OM development. These findings highlight promising targets for future immunomodulatory therapies aimed at preventing or mitigating osteomyelitis.

5 months ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CCL19 (C-C Motif Chemokine Ligand 19) • CXCL6 (C-X-C Motif Chemokine Ligand 6) • IL15 (Interleukin 15) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)

5ms

FLT3LG as an inflammatory hub bridging tumor immune surveillance to therapy response in breast cancer. (PubMed, Clin Exp Med)

Correlations with immune cell infiltration and checkpoint markers suggested that FLT3LG may predict enhanced responses to immune checkpoint inhibitors and certain targeted drugs. These findings support its potential as a multifunctional biomarker for prognosis and therapeutic decision making in breast cancer.

5 months ago

Journal • IO biomarker

TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

TP53 mutation • PIK3CA mutation

5ms

IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy. (PubMed, Cancer Immunol Res)

Consistently, human CD56brightCD16- NK cells more strongly correlated with cDC1 and FLT3LG expression than other NK cell subsets across multiple human melanoma datasets and cancer indications. This mechanistic study of NK cell regulation of FLT3LG and control of the NK cell-cDC1 axis provides insights and strategies for the development of more effective cancer immunotherapies.

5 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

IL2 (Interleukin 2) • CD27 (CD27 Molecule) • ITGAM (Integrin, alpha M) • IL15 (Interleukin 15) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

6ms

Inflammatory Proteins Profiling in Tear Fluid in Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration. (PubMed, J Ocul Pharmacol Ther)

Boxplot analysis confirmed that Flt3L, IL-18, IL-1α, IL-7, IL-8, MCP-1, MMP-1, OPG, SCF, and VEGFA were specifically elevated in nAMD compared with both PCV and NC groups, while IL-10 was specifically suppressed in PCV. Tear fluid analysis represents a feasible and noninvasive approach to investigate the pathogenesis of PCV and nAMD.

6 months ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • HGF (Hepatocyte growth factor) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TNFRSF9 (TNF Receptor Superfamily Member 9) • IL10 (Interleukin 10) • CASP8 (Caspase 8) • EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • FGF (Fibroblast Growth Factor) • IL18 (Interleukin 18) • CCL8 (C-C Motif Chemokine Ligand 8) • IL7 (Interleukin 7) • MMP1 (Matrix metallopeptidase 1) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)

6ms

Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and meningioma. (PubMed, Medicine (Baltimore))

Reverse MR suggested meningiomas might lower plasma FLT3L, C-X-C motif chemokine 11, adenosine deaminase, and hepatocyte growth factor levels. FLT3L may play a protective role in meningiomas, warranting further research on inflammatory proteins for prevention and treatment strategies.

6 months ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • HGF (Hepatocyte growth factor) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

7ms

Investigating bidirectional causality between prostate cancer and inflammatory factors: A 2-sample Mendelian randomization analysis. (PubMed, Medicine (Baltimore))

Specifically, the results suggested that Flt3L and MCP4 may be risk factors for PCa, whereas MCP2 may be a favorable factor for PCa. Conversely, adenosine deaminase, axin-1, C-X-C motif chemokine ligand 6, IL-24, IL-33, and Flt3L were involved in the downstream of PCa progression.

7 months ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • AXIN1 (Axin 1) • CXCL6 (C-X-C Motif Chemokine Ligand 6) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • IL33 (Interleukin 33)

7ms

Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity. (PubMed, Cell Rep Med)

The therapeutic efficacy of FX-armed chimeric antigen receptor (CAR)-T cells is further validated in the Flt3KO&hFLT3LG humanized mouse model. This strategy offers a promising avenue for enhancing DC-T cell interactions, paving the way for more effective immunotherapy against solid tumors.

7 months ago

Journal

SLAMF6 (SLAM Family Member 6) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

8ms

The influence of 179 lipid metabolism on head and neck cancer is mediated by 91 inflammatory factors. (PubMed, Community Dent Health)

This study identifies lipids and inflammatory markers as key mediators of HNC development, offering potential diagnostic and therapeutic targets for future research.

8 months ago

Journal

FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

8ms

Shared blood gene signature in lung adenocarcinoma and microbial lung infections: a bioinformatic analysis and in silico validation. (PubMed, Discov Oncol)

This analysis identified a blood-based 7-gene signature shared between LUAD and microbial lung infections, associated with immunosuppressive microenvironment features, suggesting a potential link between infection-driven inflammation and tumor-promoting immune modulation.

8 months ago

Journal • Gene Signature

CD8 (cluster of differentiation 8) • BCL6 (B-cell CLL/lymphoma 6) • CD163 (CD163 Molecule) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • S100A12 (S100 Calcium Binding Protein A12) • RPL22 (Ribosomal Protein L22)