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    GENE:

    FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)

    i
    Other names: FLT3LG, Fms Related Receptor Tyrosine Kinase 3 Ligand, Fms-Related Tyrosine Kinase 3 Ligand, Fms Related Tyrosine Kinase 3 Ligand, Flt3 Ligand, SL Cytokine, FLG3L, FLT3L, Flt3L, FL
    Associations

    News

    Trials
    1m
    Circulating inflammatory proteins and osteomyelitis: A bidirectional Mendelian randomization and colocalization analysis. (PubMed, Medicine (Baltimore))
    This study identified several CIPs - including TNF-β, osteoprotegerin, and adenosine deaminase - as potentially causal in OM development. These findings highlight promising targets for future immunomodulatory therapies aimed at preventing or mitigating osteomyelitis.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CCL19 (C-C Motif Chemokine Ligand 19) • CXCL6 (C-X-C Motif Chemokine Ligand 6) • IL15 (Interleukin 15) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    2ms
    FLT3LG as an inflammatory hub bridging tumor immune surveillance to therapy response in breast cancer. (PubMed, Clin Exp Med)
    Correlations with immune cell infiltration and checkpoint markers suggested that FLT3LG may predict enhanced responses to immune checkpoint inhibitors and certain targeted drugs. These findings support its potential as a multifunctional biomarker for prognosis and therapeutic decision making in breast cancer.
    Journal • IO biomarker
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    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
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    TP53 mutation • PIK3CA mutation
    2ms
    IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy. (PubMed, Cancer Immunol Res)
    Consistently, human CD56brightCD16- NK cells more strongly correlated with cDC1 and FLT3LG expression than other NK cell subsets across multiple human melanoma datasets and cancer indications. This mechanistic study of NK cell regulation of FLT3LG and control of the NK cell-cDC1 axis provides insights and strategies for the development of more effective cancer immunotherapies.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    IL2 (Interleukin 2) • CD27 (CD27 Molecule) • ITGAM (Integrin, alpha M) • IL15 (Interleukin 15) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
    2ms
    Inflammatory Proteins Profiling in Tear Fluid in Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration. (PubMed, J Ocul Pharmacol Ther)
    Boxplot analysis confirmed that Flt3L, IL-18, IL-1α, IL-7, IL-8, MCP-1, MMP-1, OPG, SCF, and VEGFA were specifically elevated in nAMD compared with both PCV and NC groups, while IL-10 was specifically suppressed in PCV. Tear fluid analysis represents a feasible and noninvasive approach to investigate the pathogenesis of PCV and nAMD.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • HGF (Hepatocyte growth factor) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TNFRSF9 (TNF Receptor Superfamily Member 9) • IL10 (Interleukin 10) • CASP8 (Caspase 8) • EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • FGF (Fibroblast Growth Factor) • IL18 (Interleukin 18) • CCL8 (C-C Motif Chemokine Ligand 8) • IL7 (Interleukin 7) • MMP1 (Matrix metallopeptidase 1) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    3ms
    Two-sample Mendelian randomization analysis of 91 circulating inflammatory protein levels and meningioma. (PubMed, Medicine (Baltimore))
    Reverse MR suggested meningiomas might lower plasma FLT3L, C-X-C motif chemokine 11, adenosine deaminase, and hepatocyte growth factor levels. FLT3L may play a protective role in meningiomas, warranting further research on inflammatory proteins for prevention and treatment strategies.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • HGF (Hepatocyte growth factor) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
    3ms
    Investigating bidirectional causality between prostate cancer and inflammatory factors: A 2-sample Mendelian randomization analysis. (PubMed, Medicine (Baltimore))
    Specifically, the results suggested that Flt3L and MCP4 may be risk factors for PCa, whereas MCP2 may be a favorable factor for PCa. Conversely, adenosine deaminase, axin-1, C-X-C motif chemokine ligand 6, IL-24, IL-33, and Flt3L were involved in the downstream of PCa progression.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • AXIN1 (Axin 1) • CXCL6 (C-X-C Motif Chemokine Ligand 6) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • IL33 (Interleukin 33)
    4ms
    Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity. (PubMed, Cell Rep Med)
    The therapeutic efficacy of FX-armed chimeric antigen receptor (CAR)-T cells is further validated in the Flt3KO&hFLT3LG humanized mouse model. This strategy offers a promising avenue for enhancing DC-T cell interactions, paving the way for more effective immunotherapy against solid tumors.
    Journal
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    SLAMF6 (SLAM Family Member 6) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
    5ms
    The influence of 179 lipid metabolism on head and neck cancer is mediated by 91 inflammatory factors. (PubMed, Community Dent Health)
    This study identifies lipids and inflammatory markers as key mediators of HNC development, offering potential diagnostic and therapeutic targets for future research.
    Journal
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    FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
    5ms
    Shared blood gene signature in lung adenocarcinoma and microbial lung infections: a bioinformatic analysis and in silico validation. (PubMed, Discov Oncol)
    This analysis identified a blood-based 7-gene signature shared between LUAD and microbial lung infections, associated with immunosuppressive microenvironment features, suggesting a potential link between infection-driven inflammation and tumor-promoting immune modulation.
    Journal • Gene Signature
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    CD8 (cluster of differentiation 8) • BCL6 (B-cell CLL/lymphoma 6) • CD163 (CD163 Molecule) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • S100A12 (S100 Calcium Binding Protein A12) • RPL22 (Ribosomal Protein L22)
    5ms
    Transcriptomic profiling of PBMCs from mammary tumor dogs reveals two distinct immune states. (PubMed, Am J Cancer Res)
    Notably, CD7, CXCL6, FASN, FLT3LG, LTB, and TNFRSF18 were significantly downregulated, marking a potential transcriptomic signature of systemic immune impairment. These findings suggest that immune dysfunction in the PI group is not solely attributable to conventional immune suppression but rather to a diminished immune activation state driven by reduced TNFRSF gene expression.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD4 (CD4 Molecule) • IL2 (Interleukin 2) • CD27 (CD27 Molecule) • TNFRSF14 (TNF Receptor Superfamily Member 14) • IL18 (Interleukin 18) • CD7 (CD7 Molecule) • FAS (Fas cell surface death receptor) • FASN (Fatty acid synthase) • TNFRSF18 (TNF Receptor Superfamily Member 18) • CXCL6 (C-X-C Motif Chemokine Ligand 6) • IL7 (Interleukin 7) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
    8ms
    FLT3LG modulates the infiltration of immune cells and enhances the efficacy of anti-PD-1 therapy in lung adenocarcinoma. (PubMed, BMC Cancer)
    FLT3LG could be considered as a diagnostic and prognostic marker for LUAD and might play a role in enhancing the therapeutic response to immunotherapy in patients with LUAD.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand)
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    PD-L1 expression
    9ms
    The causal relationship between circulating inflammatory proteins and heart failure: A two-sample Mendelian randomization study. (PubMed, Medicine (Baltimore))
    In this study, 9 of the 91 circulating inflammatory proteins were causally related to the ICM (4 positive, 5 negative), 7 were causally related to the DCM (5 positive, 2 negative), and 4 were causally related to the HCM (all negative). This study provides a theoretical foundation for the study of the relevant mechanisms of heart failure, clinical diagnosis, and treatment, as well as potential drug candidates closely related to heart failure.
    Journal • Causal relationship
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    FLT3 (Fms-related tyrosine kinase 3) • HGF (Hepatocyte growth factor) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • IL10 (Interleukin 10) • EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • LIFR (LIF Receptor Subunit Alpha) • CD40LG (CD40 ligand) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • FLT3LG (Fms Related Receptor Tyrosine Kinase 3 Ligand) • LIF (LIF Interleukin 6 Family Cytokine)