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    BIOMARKER:

    FLT1 overexpression

    i
    Other names: FLT1, FLT, VEGFR1, Fms-related tyrosine kinase 1
    Entrez ID:
    2321
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    over2years
    VEGF and VEGFR family members are expressed by neoplastic cells of NF1-associated tumors and may play an oncogenic role in malignant peripheral nerve sheath tumor growth through an autocrine loop. (PubMed, Ann Diagn Pathol)
    Whether or not it drives an oncogenic autocrine/paracrine loop in neoplastic cells, participating in an increased activation of signaling pathways downstream of tyrosine kinase receptors, including VEGFRs, is a tempting hypothesis. Nevertheless, the specific targeting of angiogenesis in MPNSTs may not be sufficient to slow down tumor growth.
    Journal
    |
    NF1 (Neurofibromin 1) • KDR (Kinase insert domain receptor) • VEGFA (Vascular endothelial growth factor A) • FLT1 (Fms-related tyrosine kinase 1)
    |
    KDR expression • FLT1 overexpression • VEGFA expression • FLT1 expression • VEGFA expression + FLT1 expression + KDR expression