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    GENE:

    FLNC (Filamin C)

    i
    Other names: Filamin C, ABPL, Actin Binding Protein 280, ABP-280-Like Protein, Filamin C, Gamma, Gamma Filamin, Filamin-C, Filamin-2, ABP-280, FLN2, Filamin C, Gamma (Actin Binding Protein 280), Actin-Binding-Like Protein, ABP-L, Gamma Filamin, Gamma-Filamin, ABP280A, CMH26, FLN-C, ABP-L, ABPA, MFM5, MPD4, RCM5, FLNC, FLNc
    Associations

    News

    Trials
    1m
    Recurrent Myocarditis After COVID Vaccination in a Patient With FLNC Mutation Undergoing Treatment for Lymphoma. (PubMed, JACC Case Rep)
    Myocarditis may be the initial presentation for certain genetic cardiomyopathies. Genetic testing should be strongly considered in patients with multiple episodes of myocarditis.
    Journal • IO biomarker
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    FLNC (Filamin C)
    2ms
    A Comprehensive Analysis of Novel Variations Associated with Bile Duct Cancer: Insights into Expression, Methylation, and 3D Protein Structure. (PubMed, Int J Mol Sci)
    This multi-omics, public data-driven synthesis delineates a coherent network of genomic, epigenomic, transcriptomic, and structural vulnerabilities, offering a rational framework for therapeutic targeting of cholangiocarcinoma. This study reveals novel bile duct-associated variations that expand our understanding of cholangiocarcinoma pathogenesis and provide potential targets for precision medicine approaches.
    Journal
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • TUBB3 (Tubulin beta 3 class III) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • FLNC (Filamin C)
    4ms
    Disulfidptosis-linked Gene Signatures Constituted of Prognostic Prediction Models in Prostate Cancer. (PubMed, Cancer Diagn Progn)
    In particular, the prognostic formula comprising ZHX2, SMPD4, and CHD4 using the Lasso-Cox regression model properly distinguished the BCR-free survival curves, indicating that these genes could be signatures for disulfidptosis. Decoding disulfidptosis-related data in the transcriptome would provide crucial clues for finding novel approaches to personalized cancer medicine in prostate cancer.
    Journal • Gene Signature
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    CHD4 (Chromodomain Helicase DNA Binding Protein 4) • DBN1 (Drebrin 1) • FLNC (Filamin C)
    5ms
    Multi-Omics Integrated Analysis of the Protective Effect of Tertiary Lymphoid Structures and Associated Key Regulatory Genes in Human Gallbladder Cancer. (PubMed, J Gene Med)
    In conclusion, TLS had a protective effect on human GBC, and its related genes, played a potential role in diagnosis, prognosis, immune infiltration, and metastasis of GBC. Our findings provided a new insight for the research on clinical biomarkers of GBC and development of its therapeutic targets.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) • CCNB1 (Cyclin B1) • FLNC (Filamin C) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • MYLK (Myosin Light Chain Kinase)
    7ms
    Long Term Survivors of Anaplastic Thyroid Cancer: A Genomic Predictive Model. (PubMed, J Clin Endocrinol Metab)
    This model identifies mutated genes that are associated with the most aggressive ATCs and thus may aid in preoperative risk assessment when evaluating patients for surgery for curative intent.
    Journal
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    BRAF (B-raf proto-oncogene) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MUC4 (Mucin 4, Cell Surface Associated) • RECQL4( RecQ Like Helicase 4) • ZMYND8 (Zinc Finger MYND-Type Containing 8) • FLNC (Filamin C) • MAPK12 (Mitogen-Activated Protein Kinase 12)
    8ms
    Unveiling the multifaceted role of the FLNC gene: implications for cancer diagnosis and prognosis. (PubMed, Eur J Med Res)
    In conclusion, our research provides insights into the versatile role of FLNC in cancer biology, emphasizing its clinical significance and potential applications as a diagnostic, prognostic, and therapeutic target across diverse cancer types. These findings offer valuable insights for personalized therapeutic interventions and precision medicine approaches.
    Journal
    |
    FLNC (Filamin C)
    8ms
    Spatial transcriptomics and multi-omics reveal relapse and resistance mechanisms of EndMT-derived CAFs mediated by TNC and FLNC in glioblastoma. (PubMed, J Transl Med)
    These discoveries indicate that TNC and FLNC induced EndMT was a key resource of CAFs and targeting TNC and FLNC to inhibit EndMT and the collagen pathway is a promising tactic for reversing drug resistance in tumours. The development of combined chemotherapeutic strategies based on the features of tumour microenvironment endothelial cells and ECM deposition has high potential clinical value in increasing the efficacy of tumour treatment.
    Journal
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    COL1A1 (Collagen Type I Alpha 1 Chain) • FLNC (Filamin C)
    |
    temozolomide
    8ms
    Machine Learning and Experimental Validation Reveal MYH11 as a Novel Prognostic Biomarker and Therapeutic Target in Bladder Cancer. (PubMed, J Inflamm Res)
    Functional experiments showed that MYH11 knockdown promoted cell proliferation, migration, and invasion. This study identified 8 prognostic genes to construct a risk model, and suggest that MYH11 is a potential diagnostic and prognostic biomarker for BCa.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    FLNC (Filamin C)
    8ms
    Fusion of spatiotemporal and network models to prioritize multiscale effects in single-cell perturbations. (PubMed, Brief Bioinform)
    In colitis, Perturb-STNet identified key genes (Csf1r, Col6a1, Lgr4, Myc, and Fzd5) and mediator pairs (Itga5-Flnc, Cd68-Csf1r, Csf1r-Cx3cl1, and Tnfrsf1b-Bmp1) involved in immune regulation, matrix remodeling, and epithelial repair, offering potential therapeutic targets. Overall, Perturb-STNet enables robust identification of spatiotemporal regulatory networks in single-cell perturbation data across diverse disease contexts.
    Journal
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD8 (cluster of differentiation 8) • CD79B (CD79b Molecule) • IL2RA (Interleukin 2 receptor, alpha) • CD5 (CD5 Molecule) • CD68 (CD68 Molecule) • CSF1R (Colony stimulating factor 1 receptor) • FOXP3 (Forkhead Box P3) • COL6A1 (Collagen Type VI Alpha 1 Chain) • CX3CL1 (C-X3-C Motif Chemokine Ligand 1) • KLRG1 (Killer Cell Lectin Like Receptor G1) • FLNC (Filamin C) • FZD5 (Frizzled Class Receptor 5) • ITGA5 (Integrin Subunit Alpha 5) • LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    9ms
    Immunotyping of thyroid cancer for clinical outcomes and implications. (PubMed, Cancer Immunol Immunother)
    Based on bioinformatics analysis, we constructed an immune-related prognosis model for THCA, which is expected to provide new ideas for studies related to the prognosis and treatment of THCA.
    Clinical data • Journal • IO biomarker
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    IFNG (Interferon, gamma) • IL18 (Interleukin 18) • MMP17 (Matrix Metallopeptidase 17) • TGFB1 (Transforming Growth Factor Beta 1) • FLNC (Filamin C) • MMP7 (Matrix metallopeptidase 7)
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    methotrexate • sirolimus
    10ms
    Modulation of Gene Expression by Substrate Stiffness via Ubiquitination of Histone H2B by Ubiquitin-Conjugating Enzyme E2A/B. (PubMed, ACS Omega)
    Among these, filamin C (FLNC), leucine zipper protein 1 (LUZP1), and glutamate-rich WD repeat-containing protein 1 (GRWD1) showed higher expression on stiff substrates, with GRWD1 known for its role in cancer progression through cell cycle and gene regulation. These findings highlight how substrate stiffness modulates gene expression via UBE2A/B-mediated H2B ubiquitination.
    Journal
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    H2BC8 (H2B Clustered Histone 8) • FLNC (Filamin C)