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    GENE:

    FI44L (Interferon Induced Protein 44 Like)

    i
    Other names: FI44L, Interferon Induced Protein 44 Like, Interferon-Induced Protein 44-Like, C1orf29, GS3686, TLDC5B, Chromosome 1 Open Reading Frame 29
    Associations

    News

    Trials
    12ms
    GnRHR inhibits the malignant progression of triple-negative breast cancer by upregulating FOS and IFI44L. (PubMed, Genomics)
    Overall, our results reveal that GnRHR suppresses the malignant progression of TNBC by upregulating FOS and IFI44L. Goserelin slows down the proliferation of TNBC tumors in vivo through the GnRHR/FOS/IFI44L pathway, which may present a new therapeutic approach for the management of TNBC.
    Journal
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    VIM (Vimentin) • CDH2 (Cadherin 2) • FI44L (Interferon Induced Protein 44 Like)
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    goserelin acetate
    over1year
    ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells. (PubMed, Cancer Sci)
    Our results suggest that ACSL4 upregulates interferon signaling, enhancing IFI44 and IFI44L expression and promoting HNSCC cell proliferation and invasiveness. Thus, ACSL4 could serve as a novel therapeutic target for HNSCC.
    Journal
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    JAK1 (Janus Kinase 1) • IRF1 (Interferon Regulatory Factor 1) • TYK2 (Tyrosine Kinase 2) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNA1 (Interferon Alpha 1) • FI44L (Interferon Induced Protein 44 Like) • IFNB1 (Interferon Beta 1)
    2years
    Recognizing the role of Epstein-Barr virus in gastric cancer: transcriptomic insights into malignancy modulation. (PubMed, Virol J)
    Our study underscores the capacity of EBV to exert regulatory control over genes associated with GC malignancy. In addition to its inflammatory effects, EBV elicits transcriptomic changes that appear to attenuate the progression of GC.
    Journal
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    FI44L (Interferon Induced Protein 44 Like)
    almost3years
    Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma. (PubMed, Int J Clin Oncol)
    These results indicate that the differential expression and balance of immune response and microenvironment genes may be required for PCNSL tumor growth or prognosis prediction, which would help understanding the mechanism of tumorigenesis and potential therapeutic targets in PCNSL.
    Journal
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    CXCL10 (Chemokine (C-X-C motif) ligand 10) • CSF3R (Colony Stimulating Factor 3 Receptor) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CCR7 (Chemokine (C-C motif) receptor 7) • GZMB (Granzyme B) • TGFB1 (Transforming Growth Factor Beta 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • LRP1 (LDL Receptor Related Protein 1) • FI44L (Interferon Induced Protein 44 Like) • GFAP (Glial Fibrillary Acidic Protein) • LY6E (Lymphocyte Antigen 6 Family Member E) • PLAU (Plasminogen Activator)
    3years
    IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis. (PubMed, Environ Pollut)
    Our study revealed that IFI44L promotes cell apoptosis and exerts tumor suppressors by activating the JAK/STAT1 signaling pathway. It further suggests that IFI44L has clinical therapeutic potential and may be a promising biomarker during lung carcinogenesis.
    Journal
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    FI44L (Interferon Induced Protein 44 Like) • XAF1 (XIAP Associated Factor 1)