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DRUG:

FH-TCR-Tᴍsʟɴ

i
Other names: FH-TCR-Tᴍsʟɴ, Autologous Mesothelin-specific TCR-T Cells
Associations
Company:
Fred Hutchinson Cancer Center
Drug class:
TCR modulator, Mesothelin inhibitor
Related drugs:
Associations
18d
Mesothelin-Specific T-Cells (FH-TCR-Tᴍsʟɴ) for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma (clinicaltrials.gov)
P1, N=9, Active, not recruiting, Fred Hutchinson Cancer Center | Recruiting --> Active, not recruiting | N=15 --> 9
Enrollment closed • Enrollment change
|
HLA-A (Major Histocompatibility Complex, Class I, A) • MSLN (Mesothelin)
|
MSLN expression • HLA-A*02
|
cyclophosphamide • bendamustine • fludarabine IV • FH-TCR-Tᴍsʟɴ
4ms
Mesothelin-Specific T-Cells (FH-TCR-Tᴍsʟɴ) for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma (clinicaltrials.gov)
P1, N=15, Recruiting, Fred Hutchinson Cancer Center | Trial primary completion date: Jun 2024 --> Dec 2024
Trial primary completion date • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A) • MSLN (Mesothelin)
|
cyclophosphamide • bendamustine • fludarabine IV • FH-TCR-Tᴍsʟɴ
10ms
Mesothelin-Specific T-Cells (FH-TCR-Tᴍsʟɴ) for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma (clinicaltrials.gov)
P1, N=15, Recruiting, Fred Hutchinson Cancer Center | Trial completion date: Sep 2024 --> Jun 2025 | Trial primary completion date: Dec 2023 --> Jun 2024
Trial completion date • Trial primary completion date • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A) • MSLN (Mesothelin)
|
MSLN expression • HLA-A*02
|
cyclophosphamide • bendamustine • fludarabine IV • FH-TCR-Tᴍsʟɴ