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    GENE:

    FGG (Fibrinogen Gamma Chain)

    i
    Other names: FGG, Fibrinogen Gamma Chain, Fibrinogen, Gamma Polypeptide, Testicular Tissue Protein Li 70
    Associations

    News

    Trials
    5ms
    Exosomal FGG promotes colorectal cancer liver metastases through inducing angiogenic pre-metastatic niche formation. (PubMed, Arch Biochem Biophys)
    In conclusion, FGG facilitates CRC liver metastasis by regulating key angiogenic, adhesion and mesenchymal markers via exosome-mediated mechanisms, resulting enhanced angiogenesis, vascular permeability, and EMT induction. These findings offer new insights into the mechanisms and treatment strategies of CRC liver metastasis.
    Journal
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    CDH1 (Cadherin 1) • VIM (Vimentin) • CD31 (Platelet and endothelial cell adhesion molecule 1) • CDH2 (Cadherin 2) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • CDH5 (Cadherin 5) • FGG (Fibrinogen Gamma Chain)
    5ms
    Identification of Molecular Subtypes and a Novel Prognostic Model for Lung Squamous Cell Carcinoma Based on Adenylate Uridylate (AU)-Rich Element Genes. (PubMed, J Immunother)
    In addition, the low-risk patients show increased sensitivity to vinorelbine. The molecular subtypes and prognostic model based on AREGs demonstrate reliable clinical prognostic value. This finding may contribute to personalized and precise treatment for patients with LUSC, offering new insights for improving patient outcomes.
    Journal • IO biomarker
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    AREG (Amphiregulin) • ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) • FGG (Fibrinogen Gamma Chain)
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    vinorelbine tartrate
    over2years
    MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor. (PubMed, BMC Cancer)
    Our data showed that MAPK1 can bind to the promoter regions of these target genes to control their transcription as a bidirectional transcription factor, promoting AGS cell motility and invasion. Our research has expanded the understanding of the regulatory roles of MAPK1, enriched our knowledge of transcription factors, and provided novel candidates for cancer therapeutics.
    Journal
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    MAPK1 (Mitogen-activated protein kinase 1) • FGG (Fibrinogen Gamma Chain) • KRT6A (Keratin 6A)
    over2years
    Identification of specific prognostic markers for lung squamous cell carcinoma based on tumor progression, immune infiltration, and stem index. (PubMed, Front Immunol)
    Our study demonstrated the potential clinical implication of the 7- DEGs signature for prognosis prediction of LUSC patients based on tumor progression, immune infiltration, and stem index. And the FGG could be an independent prognostic biomarker of LUSC promoting cell proliferation, migration, invasion, THP-1 cell infiltration, and stem cell maintenance.
    Journal • IO biomarker
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    FGG (Fibrinogen Gamma Chain)