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    over2years
    Tumor cell- intrinsic expression of FGFR3 drives anti-PDL-1 immunotherapy resistance in a murine bladder cancer model (SITC 2021)
    The mechanism of resistance was not dependent on receptor kinase activity. Further studies are ongoing to determine the biochemical mechanisms of FGFR3-mediated immunotherapy resistance in bladder cancer.
    Preclinical • PD(L)-1 Biomarker • IO biomarker
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    FGFR3 (Fibroblast growth factor receptor 3) • CD8 (cluster of differentiation 8)
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    FGFR3 mutation • FGFR3 G370C • FGFR3 expression • FGFR3 K508M