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    BIOMARKER:

    FGF19 negative

    i
    Other names: FGF19, Fibroblast growth factor 19
    Entrez ID:
    9965
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    28d
    A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma. (PubMed, Nat Commun)
    Thus, the embryonic biliary lineage program cooperates with stabilized nuclear β-catenin, inducing FGF19 as a paracrine growth signal that promotes tumor cell proliferation, together with active Wnt signaling. In this pediatric cancer presumed to originate from a multipotent hepatobiliary progenitor, lineage-driven heterogeneity results in a functional growth advantage, a non-genetic mechanism whereby developmental lineage programs influence tumor evolution.
    Journal
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    FGF19 (Fibroblast growth factor 19) • SOX4 (SRY-Box Transcription Factor 4)
    |
    FGF19 expression • FGF19 negative