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    BIOMARKER:

    FCGR2A R131H

    i
    Other names: FCGR2A, Fc Fragment Of IgG Receptor IIa, Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A, Fc Fragment Of IgG Low Affinity IIa Receptor (CD32), Immunoglobulin G Fc Receptor II, IgG Fc Receptor II-A, Fc-Gamma-RIIa, FcRII-A, FCGR2A1, CDw32, IGFR2, FCG2, CD32, Fc Fragment Of IgG Low Affinity IIa Receptor For (CD32), Fc Gamma Receptor RIIa3, Fc Gamma Receptor IIa, Fc-Gamma RII-A, CD32 Antigen, CD32A, FCGR2, FcGR
    Entrez ID:
    2212
    Related biomarkers:
    Expression
    Mutation
    Associations

    News

    Trials
    over4years
    Single-nucleotide Fcγ receptor polymorphisms do not impact obinutuzumab/rituximab outcome in patients with lymphoma. (PubMed, Blood Adv)
    FCGR2B was associated with poorer PFS in multivariate analyses comparing T232T with I232I in rituximab- but not obinutuzumab-treated patients with DLBCL (HR, 4.40; 95% CI, 1.71-11.32; P = .002; multiple-test-adjusted P = .03); however, this genotype was rare (n = 13). This study shows that FcγR genotype is not associated with response to rituximab/obinutuzumab plus chemotherapy in treatment-naive patients with advanced FL or DLBCL.
    Clinical • Journal
    |
    FCGR2A (Fc fragment of IgG receptor IIa) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • FCGR2B (Fc Fragment Of IgG Receptor IIb)
    |
    FCGR2A R131H • FCGR2B I232T
    |
    Rituxan (rituximab) • Gazyva (obinutuzumab)