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    GENE:

    FCGR1A (Fc Fragment Of IgG Receptor Ia)

    i
    Other names: Fc Fragment Of IgG Receptor Ia, Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64), Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64), High Affinity Immunoglobulin Gamma Fc Receptor I, Fc Gamma Receptor Ia, IgG Fc Receptor I, Fc-Gamma RIA, Fc-Gamma RI, FcgammaRIa, CD64A, IGFR1, CD64, Fc-Gamma Receptor I A1, CD64 Antigen, FCGR1A, FCGR1, FCRI, FCG1, FcRI
    26d
    Activation of FCGR2A enhances the antitumor efficacy of hPSC-derived CAR-M. (PubMed, Front Cell Dev Biol)
    Furthermore, polarization of CAR-Ms into a proinflammatory state significantly enhanced tumor-killing efficacy, particularly in FCGR2A CAR-Ms. These findings highlight the potential of FCGR2A as an optimal signaling domain for CAR-M design and underscore the therapeutic promise of proinflammatory polarized CAR-Ms in solid tumor immunotherapy.
    Journal • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • FCGR2A (Fc fragment of IgG receptor IIa) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • FCGR2B (Fc Fragment Of IgG Receptor IIb)
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    HER-2 positive • HER-2 expression
    4ms
    Spatial transcriptomic landscape and cellular neighborhood heterogeneity in cervical cancer: integrative single-cell and spatial RNA sequencing analysis. (PubMed, Discov Oncol)
    This study established the first comprehensive spatial transcriptomic atlas of cervical cancer, revealing unprecedented insights into tumor microenvironment organization and cellular spatial relationships.
    Journal
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    MUC1 (Mucin 1) • CDH1 (Cadherin 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • CD3G (CD3 Gamma Subunit Of T-Cell Receptor Complex) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IGHG1 (Immunoglobulin Heavy Constant Gamma 1) • COMP (Cartilage Oligomeric Matrix Protein) • KRT16 (Keratin 16)
    4ms
    Progressively altered genes in colorectal carcinogenesis link oncogenesis immune cycle and tumor microenvironment. (PubMed, Sci Rep)
    However, it demonstrates a declining trend in the progression of CRC from stage I to IV, which may be intricately associated with the metastasis of CRC. The WARS1 can serve as a reliable indicator of the immune response in CRC, thereby demonstrating its potential to impede tumorigenesis or metastasis.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • SECTM1 (Secreted and transmembrane 1) • SLC16A3 (Solute Carrier Family 16 Member 3) • SERPINA1 (Serpin Family A Member 1)
    5ms
    Revealing a Heterozygous FCGR1A Variant in a Patient with Uveal Melanoma and Von Hippel-Lindau Syndrome: A Rare Case Report. (PubMed, J Curr Ophthalmol)
    In the future, FCGR1A could be a promising therapeutic approach for retinal cancer due to its role in several cancers and retinal degeneration. To gain a better understanding of its pathogenesis mechanism, it is recommended to conduct functional analysis using appropriate animal models before using the variant in genetic counseling.
    Journal
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    FCGR1A (Fc Fragment Of IgG Receptor Ia)
    10ms
    The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment. (PubMed, Discov Oncol)
    This study provides the first evidence that VSIG4, CYBBC3AR1, and FCGR1A play critical roles in the immune microenvironment of colorectal cancer, particularly emphasizing the immunoregulatory function of VSIG4 in macrophage activity and CD8 + T cell immune exhaustion. PCR validation further confirmed the differential expression of these genes. These findings offer new insights into the molecular mechanisms of CRC and provide a potential theoretical basis for targeting VSIG4 in immunotherapy.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • FCGR1A (Fc Fragment Of IgG Receptor Ia)
    11ms
    Isolation, phylogenetics, and characterization of a new PDCoV strain that affects cellular gene expression in human cells. (PubMed, Front Microbiol)
    In addition, the protein levels of p-IRF3, LC3-II, and ACSL4 increased, suggesting that PDCoV infection in Huh7 cells induces an intrinsic immune response, cellular autophagy, and ferroptosis. Collectively, our findings provide new insights into the characteristics and mechanisms of PDCoV infection.
    Journal
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    KEAP1 (Kelch Like ECH Associated Protein 1) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TNFRSF9 (TNF Receptor Superfamily Member 9) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IL15 (Interleukin 15) • DUSP1 (Dual Specificity Phosphatase 1) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
    12ms
    Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis. (clinicaltrials.gov)
    P=N/A, N=200, Not yet recruiting, Chinese University of Hong Kong
    New trial
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IFI27 (Interferon Alpha Inducible Protein 27) • ALPL (Alkaline Phosphatase) • ANKRD22 (Ankyrin Repeat Domain 22) • ANXA3 (Annexin A3) • ATF3 (Activating Transcription Factor 3)
    over1year
    Neutrophil Extracellular Traps: Potential Thrombotic Markers and Therapeutic Targets in Colorectal Cancer. (PubMed, J Leukoc Biol)
    These findings indicate that NETs are actively involved in VTE in CRC. NETs are promising thrombotic marker and therapeutic target in CRC to prevent the thrombotic consequences of cancer.
    Journal
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    FCGR1A (Fc Fragment Of IgG Receptor Ia)
    over1year
    CRISPR/Cas9-based genome-wide screening for metastasis ability identifies FCGR1A regulating the metastatic process of ovarian cancer by targeting LSP1. (PubMed, J Cancer Res Clin Oncol)
    FCGR1A enhances OC metastasis by regulating LSP1, and FCGR1A is associated with poor prognosis, suggesting that FCGR1A is a potential predictive factor for detecting early postoperative metastasis.
    Journal • Metastases
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    FCGR1A (Fc Fragment Of IgG Receptor Ia)
    2years
    Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning. (PubMed, Malar J)
    This study reveals the existence of two ICD subtypes in the human immune response against P. falciparum infection. Two ICD-associated candidate hub genes were identified, and a nomogram was constructed for the classification of high parasitaemia. This study can deepen the understanding of the human immune response to P. falciparum infection and provide new targets for the prevention and control of malaria.
    Journal • IO biomarker • Machine learning
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    FCGR1A (Fc Fragment Of IgG Receptor Ia) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)
    2years
    ExBioma: Impact of the Ex-vivo Pulmonary Perfusion System on the Microbiome of Lung Grafts and Their Inflammatory Reaction. (clinicaltrials.gov)
    P=N/A, N=7, Recruiting, Vall d'Hebron Institute Research
    New trial
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    CD20 (Membrane Spanning 4-Domains A1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • IL2RA (Interleukin 2 receptor, alpha) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • FASLG (Fas ligand) • THBS1 (Thrombospondin 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • IL10 (Interleukin 10) • MMP2 (Matrix metallopeptidase 2) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • CASP3 (Caspase 3) • CCR7 (Chemokine (C-C motif) receptor 7) • CD14 (CD14 Molecule) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • TLR9 (Toll Like Receptor 9) • CASP8 (Caspase 8) • CCL2 (Chemokine (C-C motif) ligand 2) • GZMB (Granzyme B) • IL18 (Interleukin 18) • ITGAM (Integrin, alpha M) • TGFB1 (Transforming Growth Factor Beta 1) • ADAM17 (ADAM Metallopeptidase Domain 17) • CD31 (Platelet and endothelial cell adhesion molecule 1) • GZMA (Granzyme A) • IL32 (Interleukin 32) • ITGAE (Integrin Subunit Alpha E) • MMP9 (Matrix metallopeptidase 9) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT6 (Signal transducer and activator of transcription 6) • TLR3 (Toll Like Receptor 3) • CCR2 (C-C Motif Chemokine Receptor 2) • CD40 (CD40 Molecule) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IL1B (Interleukin 1, beta) • MMP1 (Matrix metallopeptidase 1) • MS4A1 (Membrane Spanning 4-Domains A1) • NOS2 (Nitric Oxide Synthase 2) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • PRF1 (Perforin 1) • TAP1 (Transporter 1) • THBS2 (Thrombospondin 2) • TNFSF10 (TNF Superfamily Member 10) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CCR3 (C-C Motif Chemokine Receptor 3) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • CTGF (Connective tissue growth factor) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1) • IL16 (Interleukin 16) • ITGA2 (Integrin Subunit Alpha 2) • STAT4 (Signal Transducer And Activator Of Transcription 4) • TGFB2 (Transforming Growth Factor Beta 2) • CASP1 (Caspase 1)
    almost3years
    GENE EXPRESSION PROFILING OF T(14;18)-NEGATIVE CD23+ FOLLICLE CENTER LYMPHOMA DEMONSTRATES ACTIVATION OF THE IL4/JAK/STAT6 PATHWAY AND A ROLE IN ITS PATHOGENESIS (ICML 2023)
    GEP identified two distinct groups within t(14;18)-neg FL, indicating different stages of differentiation of the neoplastic B cells. FLnegmut shows activation of STAT6 pathway through upregulation of CD23 and IL4R and by enrichment in GSEA and correlates with CD23 expression. Constitutive activation of STAT6 and consequent upregulation of CD23 prevent ongoing B cell differentiation in FLnegmut, precluding the cells from exiting the GC and adopting the state of activated B cell.
    IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • TNFRSF17 (TNF Receptor Superfamily Member 17) • JAK1 (Janus Kinase 1) • CD22 (CD22 Molecule) • PAX5 (Paired Box 5) • STAT3 (Signal Transducer And Activator Of Transcription 3) • PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • S100A8 (S100 Calcium Binding Protein A8) • IRF4 (Interferon regulatory factor 4) • PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • SOCS1 (Suppressor Of Cytokine Signaling 1) • TYK2 (Tyrosine Kinase 2) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • CD40 (CD40 Molecule) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) • IL4 (Interleukin 4) • FCER2 (Fc Fragment Of IgE Receptor II) • FCRLA (Fc Receptor Like A) • IL4R (Interleukin 4 Receptor) • SLAMF7 (SLAM Family Member 7) • SOCS3 (Suppressor Of Cytokine Signaling 3) • TNFRSF13B (TNF Receptor Superfamily Member 13B)
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    SOCS1 mutation
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    HTG EdgeSeq Precision Immuno-Oncology Panel