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GENE:

FCGR1A (Fc Fragment Of IgG Receptor Ia)

News alerts, weekly reports and conference planners

16d

Plasma PFDN2 suppresses head and neck squamous cell carcinoma progression by restricting CD64 on monocyte-driven inflammatory microenvironments. (PubMed, Front Immunol)

Tissue analyses further confirmed PFDN2 downregulation and CD64 upregulation in HNSC, correlating with advanced tumor grade and stage. Our findings establish PFDN2 as a protective plasma protein that restrains HNSC progression by suppressing CD64 on monocyte-mediated inflammatory immune microenvironments, highlighting the PFDN2-CD64 axis as a potential prognostic biomarker and therapeutic target.

16 days ago

Journal

FCGR1A (Fc Fragment Of IgG Receptor Ia)

2ms

Activation of FCGR2A enhances the antitumor efficacy of hPSC-derived CAR-M. (PubMed, Front Cell Dev Biol)

Furthermore, polarization of CAR-Ms into a proinflammatory state significantly enhanced tumor-killing efficacy, particularly in FCGR2A CAR-Ms. These findings highlight the potential of FCGR2A as an optimal signaling domain for CAR-M design and underscore the therapeutic promise of proinflammatory polarized CAR-Ms in solid tumor immunotherapy.

2 months ago

Journal • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • FCGR2A (Fc fragment of IgG receptor IIa) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • FCGR2B (Fc Fragment Of IgG Receptor IIb)

HER-2 positive • HER-2 expression

5ms

Spatial transcriptomic landscape and cellular neighborhood heterogeneity in cervical cancer: integrative single-cell and spatial RNA sequencing analysis. (PubMed, Discov Oncol)

This study established the first comprehensive spatial transcriptomic atlas of cervical cancer, revealing unprecedented insights into tumor microenvironment organization and cellular spatial relationships.

5 months ago

Journal

MUC1 (Mucin 1) • CDH1 (Cadherin 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • CD3G (CD3 Gamma Subunit Of T-Cell Receptor Complex) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IGHG1 (Immunoglobulin Heavy Constant Gamma 1) • COMP (Cartilage Oligomeric Matrix Protein) • KRT16 (Keratin 16)

5ms

Progressively altered genes in colorectal carcinogenesis link oncogenesis immune cycle and tumor microenvironment. (PubMed, Sci Rep)

However, it demonstrates a declining trend in the progression of CRC from stage I to IV, which may be intricately associated with the metastasis of CRC. The WARS1 can serve as a reliable indicator of the immune response in CRC, thereby demonstrating its potential to impede tumorigenesis or metastasis.

5 months ago

Journal • Tumor mutational burden

TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • SECTM1 (Secreted and transmembrane 1) • SLC16A3 (Solute Carrier Family 16 Member 3) • SERPINA1 (Serpin Family A Member 1)

6ms

Revealing a Heterozygous FCGR1A Variant in a Patient with Uveal Melanoma and Von Hippel-Lindau Syndrome: A Rare Case Report. (PubMed, J Curr Ophthalmol)

In the future, FCGR1A could be a promising therapeutic approach for retinal cancer due to its role in several cancers and retinal degeneration. To gain a better understanding of its pathogenesis mechanism, it is recommended to conduct functional analysis using appropriate animal models before using the variant in genetic counseling.

6 months ago

Journal

FCGR1A (Fc Fragment Of IgG Receptor Ia)

11ms

The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment. (PubMed, Discov Oncol)

This study provides the first evidence that VSIG4, CYBBC3AR1, and FCGR1A play critical roles in the immune microenvironment of colorectal cancer, particularly emphasizing the immunoregulatory function of VSIG4 in macrophage activity and CD8 + T cell immune exhaustion. PCR validation further confirmed the differential expression of these genes. These findings offer new insights into the molecular mechanisms of CRC and provide a potential theoretical basis for targeting VSIG4 in immunotherapy.

11 months ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • FCGR1A (Fc Fragment Of IgG Receptor Ia)

1year

Isolation, phylogenetics, and characterization of a new PDCoV strain that affects cellular gene expression in human cells. (PubMed, Front Microbiol)

In addition, the protein levels of p-IRF3, LC3-II, and ACSL4 increased, suggesting that PDCoV infection in Huh7 cells induces an intrinsic immune response, cellular autophagy, and ferroptosis. Collectively, our findings provide new insights into the characteristics and mechanisms of PDCoV infection.

1 year ago

Journal

KEAP1 (Kelch Like ECH Associated Protein 1) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TNFRSF9 (TNF Receptor Superfamily Member 9) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IL15 (Interleukin 15) • DUSP1 (Dual Specificity Phosphatase 1) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

1year

Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis. (clinicaltrials.gov)

P=N/A, N=200, Not yet recruiting, Chinese University of Hong Kong

1 year ago

New trial

IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IFI27 (Interferon Alpha Inducible Protein 27) • ALPL (Alkaline Phosphatase) • ANKRD22 (Ankyrin Repeat Domain 22) • ANXA3 (Annexin A3) • ATF3 (Activating Transcription Factor 3)

over1year

Neutrophil Extracellular Traps: Potential Thrombotic Markers and Therapeutic Targets in Colorectal Cancer. (PubMed, J Leukoc Biol)

These findings indicate that NETs are actively involved in VTE in CRC. NETs are promising thrombotic marker and therapeutic target in CRC to prevent the thrombotic consequences of cancer.

over 1 year ago

Journal

FCGR1A (Fc Fragment Of IgG Receptor Ia)

almost2years

CRISPR/Cas9-based genome-wide screening for metastasis ability identifies FCGR1A regulating the metastatic process of ovarian cancer by targeting LSP1. (PubMed, J Cancer Res Clin Oncol)

FCGR1A enhances OC metastasis by regulating LSP1, and FCGR1A is associated with poor prognosis, suggesting that FCGR1A is a potential predictive factor for detecting early postoperative metastasis.

almost 2 years ago

Journal • Metastases

FCGR1A (Fc Fragment Of IgG Receptor Ia)

2years

Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning. (PubMed, Malar J)

This study reveals the existence of two ICD subtypes in the human immune response against P. falciparum infection. Two ICD-associated candidate hub genes were identified, and a nomogram was constructed for the classification of high parasitaemia. This study can deepen the understanding of the human immune response to P. falciparum infection and provide new targets for the prevention and control of malaria.

2 years ago

Journal • IO biomarker • Machine learning

FCGR1A (Fc Fragment Of IgG Receptor Ia) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)

2years

ExBioma: Impact of the Ex-vivo Pulmonary Perfusion System on the Microbiome of Lung Grafts and Their Inflammatory Reaction. (clinicaltrials.gov)

P=N/A, N=7, Recruiting, Vall d'Hebron Institute Research

2 years ago

New trial

CD20 (Membrane Spanning 4-Domains A1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • IL2RA (Interleukin 2 receptor, alpha) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • FASLG (Fas ligand) • THBS1 (Thrombospondin 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • IL10 (Interleukin 10) • MMP2 (Matrix metallopeptidase 2) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • CASP3 (Caspase 3) • CCR7 (Chemokine (C-C motif) receptor 7) • CD14 (CD14 Molecule) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • TLR9 (Toll Like Receptor 9) • CASP8 (Caspase 8) • CCL2 (Chemokine (C-C motif) ligand 2) • GZMB (Granzyme B) • IL18 (Interleukin 18) • ITGAM (Integrin, alpha M) • TGFB1 (Transforming Growth Factor Beta 1) • ADAM17 (ADAM Metallopeptidase Domain 17) • CD31 (Platelet and endothelial cell adhesion molecule 1) • GZMA (Granzyme A) • IL32 (Interleukin 32) • ITGAE (Integrin Subunit Alpha E) • MMP9 (Matrix metallopeptidase 9) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT6 (Signal transducer and activator of transcription 6) • TLR3 (Toll Like Receptor 3) • CCR2 (C-C Motif Chemokine Receptor 2) • CD40 (CD40 Molecule) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • FCGR1A (Fc Fragment Of IgG Receptor Ia) • IL1B (Interleukin 1, beta) • MMP1 (Matrix metallopeptidase 1) • MS4A1 (Membrane Spanning 4-Domains A1) • NOS2 (Nitric Oxide Synthase 2) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • PRF1 (Perforin 1) • TAP1 (Transporter 1) • THBS2 (Thrombospondin 2) • TNFSF10 (TNF Superfamily Member 10) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CCR3 (C-C Motif Chemokine Receptor 3) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • CTGF (Connective tissue growth factor) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1) • IL16 (Interleukin 16) • ITGA2 (Integrin Subunit Alpha 2) • STAT4 (Signal Transducer And Activator Of Transcription 4) • TGFB2 (Transforming Growth Factor Beta 2) • CASP1 (Caspase 1)