FCER2 (Fc Fragment Of IgE Receptor II)

pseudo-RT is a reversible event, and awareness of its characteristic features is essential to prevent overtreatment.

In addition to these mechanisms, Notch2 acts as a transcription factor that directly controls the expression of key targets, such as CD23 and Hes1, that are fundamental for B cell proliferation, differentiation, and survival in CLL. All of these circuits represent important therapeutic targets and help explain the cells' dependence on their niche, the formation of proliferation centers, and resistance to modern targeted agents.

FDCS has a unique histological morphology and immunophenotype for FDCS. It is rare for FDCS to occur in the lungs. However, owing to the lack of experience among doctors and the limitations of small biopsy specimens, FDCS can easily be misdiagnosed as lung cancer. When tumour cells exhibit the above histological features, additional immunostaining for FDC markers should be performed. The Clinical Trial Number is ChiCTR2400090730 and Reg Date is October 12, 2024.

NGS revealed that a common progenitor cell with BCL2-IgH translocation and mutations in TP53, KMT2A, KMT2C, and KMT2D gave rise to two distinct subclones: one (CD5 + CD23+CD200+) CLL driven by mutations in TNFAIP3 and BCORL1, and the other (CD5-CD23-CD200-) driven by mutations in EP300, NOTCH1, and BCL2. This case highlights the significance of clonal heterogeneity in CLL and underscores the crucial role of MFC, flow sorting, and molecular genetics in diagnosing and understanding the complex evolution of this disease.

P2, N=120, Recruiting, Mayo Clinic | Trial primary completion date: Oct 2030 --> Mar 2027

The patient was started on bendamustine and rituximab chemotherapy. This case highlights that parotid swellings may conceal systemic lymphomas, and misleading cytology can delay diagnosis. Clinicians should consider MCL in atypical parotid lesions to ensure early systemic therapy.

Whole-body positron emission tomography (PET) showed no hypermetabolic lymphadenopathy or visceral disease. The patient underwent excision of the back nodule with complex primary closure, and follow-up examinations have shown a well-healed scar without local recurrence. This case illustrates how CLL/SLL can present with a solitary cutaneous nodule and underscores the importance of histopathology and immunophenotyping in distinguishing secondary cutaneous involvement by systemic lymphoma from PCBCLs, as management and prognosis differ.

FDCS is a rare neoplasm with variable morphologic and staining patterns. To the best of our knowledge, this is the first reported instance of pleura-based FDCS with epithelioid morphology and aberrant expression of cytokeratins. Diagnosis of such cases can be challenging, which has to be separated from the morphologic mimicries, particularly carcinoma and mesothelioma.

P3, N=466, Not yet recruiting, Alliance for Clinical Trials in Oncology

The patient remains asymptomatic and under active surveillance for both conditions. Subtle hematologic abnormalities may indicate early stages of HCL, and internists play a crucial role in recognizing these early signs and initiating targeted diagnostic evaluation.

P2, N=22, Recruiting, Zulfa Omer | Not yet recruiting --> Recruiting

P2, N=62, Recruiting, Zulfa Omer | Not yet recruiting --> Recruiting | Initiation date: Jun 2025 --> Dec 2025