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DRUG:

fluorobenzyl polyethylene glycol mono-triazole tetraiodothyroacetic acid (fb-PMT)

i
Other names: fb-PMT, NP751, NP-100
Associations
Trials
Company:
NanoPharmaceuticals
Drug class:
αvβ3 integrin antagonist
Associations
Trials
over1year
Preclinical Assessment of Drug-drug interaction of fb-PMT, a novel anti-cancer thyrointegrin αvβ3 antagonist. (PubMed, Clin Transl Sci)
However, fb-PMT inhibited the uptake of rosuvastatin by both OATP1B1 and OATP1B3 with IC s >3 and <10 μM. In summary, data suggest that the systemic administration of fb-PMT is unlikely to lead to DDIs through CYP enzymes or ABC and SLC transporters in humans.
Preclinical • Journal
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CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4)
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fluorobenzyl polyethylene glycol mono-triazole tetraiodothyroacetic acid (fb-PMT)