FAT2 (FAT Atypical Cadherin 2)

Chimeric antigen receptor (CAR)-T cells targeting FAT2 demonstrate anti-tumor activity. This work lays the foundation for developing FAT2-targeted therapies and represents a pivotal platform to inform therapeutic target discovery across cancers.

These findings demonstrate the wide morphological and immunophenotypic spectrum of EBV+ IFDCS. Furthermore, variants in chromatin modifier and HRR-related genes may participate in its pathogenesis, and PARP inhibition may represent a potential therapeutic strategy for patients with unresectable disease.

Ginsenosides alleviate inflammation induced by ELF-EMF by downregulating inflammatory-related cytokines and proteins. It also had an effect on decreasing nerve cell apoptosis by reducing inflammatory response.

One case is clearly classified as DMG, while others have insufficient calibrated scores. Based on these results, we speculate that DMG-SCs with piloid features may represent a unique subtype with a more favorable prognosis.

Orai1 induces NFAT2 nuclear translocation in MCF-7 cells and NFAT2 overexpression attenuates ERα and Orai3 protein content in cells expressing Orai1. Our findings show that Orai1 is functionally associated with sustaining Orai3 synthesis and stability and ERα expression in luminal breast cancer cells, consequently modulating the ERα-Orai3 axis, rather than acting as a primary SOCE component.

In sum, all these results position MA as a novel NFAT2 inhibitor to overcome P-gp-mediated MDR via modulating calcium signaling, which points to further investigation for its clinical applications.

This study comprehensively integrated and analyzed research results on the characteristics of the FAT gene family in lung cancer, focusing on its mutations, signaling pathways, and immunological roles, as well as its clinical significance in terms of prognosis. This study provides theoretical support and references for the development of targeted therapeutic strategies.

The identification of the main tumor suppressors in the regenerating blastema that inhibit human cancer cells in-vitro remains open. The evolution of this process of tumor self-remission indicated as tail regeneration in lizards remains unknown but is worth for further research.

Furthermore, our in silico modeling validates that the spatial pattern of myosin directly regulates the orientation of cortical F-actin arrangement. These findings establish a novel mechano-metabolic link between matrix compliance and detrimental mediators-NF-κB/XBP1s, GFAT, and hyaluronan-uncovering a potential microenvironmental reprogramming strategy adopted by tumor cells in soft niches.

The child received systemic chemotherapy and intrathecal topotecan as CNS prophylaxis, along with enucleation of the left eye...These processes are key drivers of cancer progression and metastasis. Proteomic analysis could be valuable in identifying proteins modulated in CSF during disease progression in RB patients, offering potential for new prognostic biomarkers.

NFAT2 knockdown reduced tumorigenesis. Our study uncovered a mechanism by which NFAT2 increases HCC cell resistance to sorafenib by altering intracellular calcium ion signals, highlighting NFAT2 as a promising target for HCC drug therapy.

The intraperitoneal (IP) administration of Epi-FAT2 in Wild Indian Karyotype (WIK) adult zebrafish revealed its superior blood-brain barrier (BBB) penetration capability with greater/diverse tissue-dependent accumulation. The promising results of FAT-2 in both in vitro and in vivo studies highlight its potential for the delivery of CNS therapeutics and exemplify the importance of suitable scaffold modification in CPPs for future studies.