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BIOMARKER:

FAP expression

i
Other names: FAP, DPPIV
Entrez ID:
2d
This study suggested the possible application of FAPI radioligand therapy in FAP-expressing pancreatic cancer. Further evaluation is necessary to find the best radionuclide with shorter half-life, as well as the combination with therapies targeting tumour cells directly.
Preclinical • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46 • FAPI-74
3d
FAPI-PET is a valuable diagnostic tool in patients with sarcoma. We confirm an association of tumoral FAPI-PET uptake intensity and histopathological FAP expression in sarcoma patients. We further demonstrate high accuracy of FAPI-PET and, when compared to FDG-PET, similarly high detection rate and reproducibility.
FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
7d
Expression of GATA3 and CK5 did not differ between progressors vs. non-progressors, and were not prognostic for these outcomes. FAP might serve as an easily applicable prognostic biomarker to risk-stratify patients with HG T1 NMIBC if these results are prospectively validated in a larger series.
Journal
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FAP (Fibroblast activation protein, alpha) • GATA3 (GATA binding protein 3)
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FAP expression
15d
This review discusses the basic biological characteristics of FAP and its applications in the diagnosis and treatment of various cancers. We review the emerging basic and clinical research data regarding the use of nanomaterials that target FAP.
Review • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
15d
Metastatic HCCs to various organs showed different pathological features. VETC and MTM subtypes were related to lung metastasis, whereas K19 expression, EMT-high features with fibrous tumor stroma and high immune cell infiltration were related to lymph node metastasis.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • VEGFA (Vascular endothelial growth factor A) • CD163 (CD163 Molecule) • CD34 (CD34 molecule) • CA9 (Carbonic anhydrase 9) • FOXP3 (Forkhead Box P3)
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PD-L1 expression • FAP expression • CD163 expression • FOXP3 expression
1m
[F]AlF-labeled FAPI derivatives represent powerful tracers for PET. Owing to an excellent performance in PET imaging, FAPI-74 can be regarded as a promising precursor for [F]AlF-based FAP-imaging.
Journal
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FAP (Fibroblast activation protein, alpha) • DPP4 (Dipeptidyl Peptidase 4)
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FAP expression
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FAPI-74
1m
Low radiation doses to organs at risk suggest feasibility of repeat cycles of Y-FAPI-46. We observe signs of clinical activity, but further studies are warranted to determine efficacy and toxicity profile in a larger cohort.
Clinical • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
2ms
These changes define common immuno-morphological signatures compatible with cancer immune escape and acquired resistance to therapeutic interventions across different types of malignancy. They also may contribute to the search of new targets for cancer treatment, such as FAP-expressing cancer-associated fibroblasts, in refractory bladder tumors.
Journal • PD(L)-1 Biomarker • IO biomarker
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FAP (Fibroblast activation protein, alpha)
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PD-L1 expression • FAP expression
2ms
Ga-FAPI-PET/CT is a promising imaging modality for ACC, increasing the accuracy of staging exams and radiotherapy planning volumes, as compared conventional to CT and MRI.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
2ms
FAP mesenchymal cells express proangiogenic factors, but in comparison to normal pericytes exhibit decreased levels of antiangiogenic molecules and an increased Angiopoietin 2/1 ratio. Our results show that FAP mesenchymal cells promote angiogenesis and glioma cell migration and growth by paracrine communication and in this manner, they may thus contribute to glioblastoma progression.
Journal
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FAP (Fibroblast activation protein, alpha) • ENG (Endoglin)
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FAP expression
2ms
Patients and PET-Scans of 15 patients with fILD and suspected LC were acquired 10, 60 and 180 minutes after the administration of 150-250 MBq of a Ga labelled FAPI tracer (FAPI-46)... FAPI-PET/CT imaging is a promising new imaging modality for fILD and LC. Its potential clinical value for monitoring and therapy evaluation of fILD should be investigated in future studies.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
3ms
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
3ms
 Ga-FAPI-04 is more sensitive than F-FDG in detecting the early stage of tumor metastasis, but becomes less sensitive than F-FDG at the late stage of tumor metastasis. We envision this result would be meaningful for the explanation of the  Ga-FAPI-04 and F-FDG imaging both in the future clinic and preclinic studies.
Preclinical • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
4ms
Both enabled imaging of FAP-expressing tumors specifically in vivo. [In]QCP02 showed high uptake at 18.2 percent injected dose per gram in the U87 tumor at 30 min post-administration.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
4ms
In addition, based on its ability to suppress antitumor immunity in GBM and induce temozolomide resistance, FAP may be a potential target for immunotherapy and reversing temozolomide resistance; however, current studies on therapies targeting FAP are still limited. In this review, we summarized recent progress in FAP expression profiling and the understanding of the biological function of FAP in GBM and raised the possibility of FAP as an imaging biomarker and therapeutic target.
Clinical • Review • Journal • IO biomarker
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FAP (Fibroblast activation protein, alpha) • FGF21 (Fibroblast Growth Factor 21)
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FAP expression
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temozolomide
4ms
The tumor-to-liver ratios were 6.26 ± 4.17 in indolent NHL and > 9 in other subtypes. Ga-FAPI imaging can be used to detect FAP expression in lymphoma lesions and may be an alternate method for characterizing lymphoma profiles.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
4ms
We also provide evidences that both FAP and ENO1 are associated with CRC stages, and high levels of FAP and ENO1 predict a poor survival in CRC patients. In summary, our work could provide a novel mechanism of FAP in CRC cells and a potential strategy for treatment of metastatic CRC.
Journal
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FAP (Fibroblast activation protein, alpha) • ENO1 (Enolase 1)
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FAP expression
5ms
Skin fibroblasts represent important components of the TME in MF. In co-culture model, normal and MF fibroblasts have differential influence on T-cell phenotype in modulating expression of Th1 cytokine and CTCL biomarker genes to reveal distinct roles with implications in MF progression.
Journal
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IFNG (Interferon, gamma) • TBX21 (T-Box Transcription Factor 21) • ACTA2 (Actin Alpha 2 Smooth Muscle) • MKI67 (Marker of proliferation Ki-67) • GATA3 (GATA binding protein 3) • IL16 (Interleukin 16) • IL4 (Interleukin 4)
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IFNG expression • FAP expression • VIM expression
5ms
Novel radio-labelled FAP-Inhibitors (e.g. Ga-FAPI46) have shown high tumor uptake in positron emission tomography (PET) in sarcoma patients... We confirm an association of tumoral FAPI-PET uptake intensity and histopathological FAP expression in sarcoma patients. Further, using blinded reads and independent histopathological validation we report high PPV and sensitivity of FAPI-PET for sarcoma staging.
Clinical • Observational data • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
5ms
Clinical • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
6ms
Modulation of autophagy by rapamycin, 3-methyladenine or ATG-5 knockdown regulated the expression of CAFs markers, suggesting a role of autophagy in the tumor promotion mechanism of TGF-β1-induced CAFs activation...Taken together, we conclude that both autophagy and FAP-α are required for breast cancer cell invasion and metastasis. Targeting autophagy or FAP-α rather than both can serve as a potential approach to improve the prognosis for human breast cancer.
Journal
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TGFB1 (Transforming Growth Factor Beta 1) • VIM (Vimentin)
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FAP expression
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sirolimus
7ms
The study identifies FAP intensity as a candidate independent NSCLC prognostic biomarker. The study also suggests continued analyses of the relationships between genetic driver mutations and the composition of tumor stroma, as well as continued probing of marker-defined fibroblasts as NSCLC subset-specific modifiers of immune surveillance and outcome.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • CD8 (cluster of differentiation 8)
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PD-L1 expression • TP53 mutation • FAP expression
7ms
(4) Due to its high tumor to background contrast, FAPI-PET/CT seems to be a superior imaging modality compared to the current gold standard contrast-enhanced CT in pancreatic cancer. For the first time, we demonstrate how FAPI-PET/CT could facilitate target definition and increases consistency in radiation oncology in pancreatic cancer.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
7ms
Clinical • New trial
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FAP (Fibroblast activation protein, alpha)
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FAP expression
8ms
We further present evidence of FAP regulation by TGFbeta-1 secreted by glioma cells. Our results provide insight into the previously unrecognized regulation of FAP expression by autocrine and paracrine TGFbeta-1 signaling in a broad spectrum of cell types present in the glioblastoma microenvironment.
Journal
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TGFB1 (Transforming Growth Factor Beta 1) • FAP (Fibroblast activation protein, alpha)
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FAP expression
9ms
The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
9ms
An oncolytic adenovirus, ICOVIR15, carrying ∆24-E1A and an RGD-fiber, infects and depletes FAP+ pericytes as well as GBM cells in murine GBM. Our study thus identifies FAP+/PDGFRβ+ pericytes as a major CAF-like stromal cell population in GBM, and highlights the unique property of this oncolytic adenovirus to target both GBM cells and GBM-associated stromal FAP+ cells.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
10ms
Epithelial FAP expression (HR 0.4 95% CI 0.20-0.78; p=.007) but not stromal FAP expression was significantly associated with better survival in univariable and multivariable analysis. FAP overexpression is evident in dCCA. There was a positive association between epithelial FAP expression and better survival which merits further evaluation.
Clinical • Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
10ms
A high expression of FAP and low levels sFAP are significantly associated with high tumour diameter, high grade, and high pT stage, lymph node invasion, development of early metastases, and worse 5-year cancer specific survival of CCRCC patients. (4) These findings corroborate the potential usefulness of FAP immunohistochemistry and plasma sFAP as a biomarker of CCRCC progression and point to CAF-related proteins as promising immunohistochemical biomarkers for the differential diagnosis of ChRCC and RO.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
11ms
Until recently, this development has outpaced an understanding of the biology; impeding optimal translation into the clinic. A summary of these applications is provided with an emphasis on eliminating tumor-infiltrating FAP-positive cells to overcome stromal barriers to immuno-oncological responses.
Journal
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VEGFA (Vascular endothelial growth factor A) • FAP (Fibroblast activation protein, alpha)
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FAP expression
11ms
Moreover, we showed that administration of the inhibitor in a mouse model of IPF inhibited PI3K activation in fibrotic lungs, suppressed production of hydroxyproline (major building block of collagen), reduced collagen deposition, and increased mouse survival. Collectively, these studies suggest that a FAP-targeted PI3K inhibitor might be promising for treating IPF.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
11ms
High-level expression of FAP was associated with poor prognosis of HGSOC via FN1 pathway.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
11ms
Single-cell analyses of dissociated tumors facilitated a detailed characterisation of the main cellular components of the glioblastoma microenvironment and revealed that vessel-localised FAP is because of expression on both ECs and pericytes. Fibroblast activation protein is expressed by multiple cell types within glioblastoma, highlighting it as an ideal immunotherapy antigen to target destruction of both tumor cells and their supporting vascular network.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
11ms
Non-invasive imaging of FAP expression by [Ga]FAPI PET/CT resulted in a better visual detection of the malignant primary in CUP, as compared to [F]FDG imaging. However, the detection rate of lymph node metastases was inferior, presumably due to low FAP expression in small metastases. Nevertheless, by offering a detection method for primary tumors with the potential of lower false positive rates and thus avoiding biopsies, patients with CUP syndrome may benefit from [Ga]FAPI PET/CT imaging.
Journal
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FAP (Fibroblast activation protein, alpha)
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FAP expression
11ms
P1, N=30, Recruiting, Jonsson Comprehensive Cancer Center | Not yet recruiting --> Recruiting
Clinical • Enrollment open
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
1year
P1, N=30, Recruiting, Jonsson Comprehensive Cancer Center | Not yet recruiting --> Recruiting
Clinical • Enrollment open
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
1year
Legal entity responsible for the study: Clovis Oncology, Inc., 3B Pharmaceuticals GmbH. Funding: Clovis Oncology, Inc., 3B Pharmaceuticals GmbH.
Preclinical
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAP-2286
1year
P1, N=30, Not yet recruiting, Jonsson Comprehensive Cancer Center
Clinical • New P1 trial
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46
1year
Clinical • New P1 trial
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FAP (Fibroblast activation protein, alpha)
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FAP expression
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FAPI-46