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    BIOMARKER:

    FANCE expression

    i
    Other names: FANCE, FA Complementation Group E, FACE, FAE, Fanconi Anemia Complementation Group E, Fanconi Anemia Group E Protein, Protein FACE
    Entrez ID:
    2178
    over2years
    Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer. (PubMed, J Cancer)
    FANCE participated in regulating several pathways. The study demonstrates the reduction of FANCE expression leads to genomic instability, thereby promoting the development of EC by regulating cell cycle.
    Journal
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    FANCE (FA Complementation Group E)
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    FANCE expression
    3years
    Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E. (PubMed, Front Genet)
    Conclusively, FANCE potential to serve as a biomarker for cancer prognosis and may predict cancer immunotherapy responses. Fance heterozygous mutant resulted in increased tumorigenesis and poor prognosis in mice.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker • Pan tumor
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • FANCE (FA Complementation Group E)
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    FANCE expression