Fallopian Tube Cancer

P3, N=468, Recruiting, Hansoh BioMedical R&D Company | Not yet recruiting --> Recruiting

P1, N=27, Completed, Memorial Sloan Kettering Cancer Center | Active, not recruiting --> Completed | N=40 --> 27 | Trial completion date: Aug 2026 --> Dec 2025 | Trial primary completion date: Aug 2026 --> Dec 2025

P2, N=27, Not yet recruiting, Mayo Clinic

Foamy cell change is a distinctive cytoplasmic alteration in STIC and HGSC. The presence of this histologic feature should prompt immunohistochemical studies to confirm serous differentiation.

A total of 44 manuscripts were retrieved, with only two articles reporting data on pregnancy with vitrified oocytes after fertility-sparing surgery, and 3 cases included. Whilst more research is required for assisted reproductive technology and ovarian cancer, and for the elucidation of the role of BRCA mutations on fertility, the present report aims to provide impetus to further research in this field.

Ribociclib plus letrozole met the primary end point, achieving meaningful response rates and durable disease control in recurrent LGSOC. The safety profile was consistent with prior CDK4/6 inhibitor studies. This combination represents a therapeutic option in this rare and genomically distinct subtype.

P=N/A, N=600, Not yet recruiting, Tongji Hospital

P1/2, N=764, Recruiting, Genmab | N=569 --> 764

P=N/A, N=50, Completed, Rutgers, The State University of New Jersey | Active, not recruiting --> Completed

Interpretability analyses indicated that model decisions were based on epithelial atypia. These results support the potential of integrating deep learning screening tools into clinical workflows to augment pathologist efficiency and diagnostic accuracy in fallopian tubes.

This finding suggests that BRCA1-associated USC may be sensitive to poly ADP-ribose polymerase inhibitors, and also raises the question of whether risk-reducing hysterectomy should be considered for patients with BRCA1 mutation. USC with a BRCA1 mutation may have molecular characteristics distinct from those of sporadic USC, and further accumulation and analysis of such cases are needed to evaluate the clinical implications.

We did not observe associations between CMV DNAemia, EBV DNAemia, or hsCRP and fatigue in this survivor population. Further investigation is needed to identify causes and indicators of cancer-related fatigue following treatment for ovarian cancer.