FADD (Fas associated via death domain)

GIM model rats were established by a four-factor GIM induction protocol involving "N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), ranitidine, irregular feeding, and sodium salicylate"...Compared with the model group, the Shuangshen Yiwei Granules group exhibited alleviated mental state, general conditions, and pathological features of the gastric mucosa, significantly upregulated PGⅠ, PGⅠ/PGⅡ ratio, and G-17(P<0.05, P<0.01), significantly downregulated PGⅡ(P<0.01), ameliorated parietal cell ultrastructure to varying degrees, significantly reduced gastric glandular apoptosis(P<0.01), significantly lowered gastric pH(P<0.01), significantly decreased expression of p-JAK2/JAK2, p-STAT3/STAT3, Bax/Bcl-2, TNFR1, TRADD, FADD, and cleaved caspase-8/caspase-8(P<0.05, P<0.01), and significantly increased expression of HRH_2, CDK5, STX3, and SNAP25(P<0.05). To sum up, Shuangshen Yiwei Granules potentially inhibit JAK2/STAT3 and TNFR1/caspase-8 signaling pathways to suppress gastric glandular apoptosis while activating CDK5/SNAREs to enhance parietal cell acid secretion, thereby restoring gastric acid homeostasis and blocking GIM progression.

Among the tested combinations, RA and Paclitaxel (PTX) exhibited enhanced cytotoxicity and synergistic activity compared with individual treatments, whereas other combinations demonstrated limited efficacy...Although the combined treatment reduced tumor volume in vivo, its antitumor efficacy was comparable to that of RA monotherapy. Collectively, these findings indicate that while the RA+PTX combination enhanced cytotoxicity activity against triple-negative breast cancer in vitro, its therapeutic advantage in vivo requires further investigation.

By integrating mechanistic insights with translational pharmacology, this review positions PANoptosis as both a therapeutic target and an adjuvant framework, outlining how its selective modulation could transform the management of infectious, inflammatory, oncologic, and neurodegenerative diseases. Schematic representation of major human disease categories associated with dysregulated PANoptosis.

In the middle and late developmental stages of E. tenella, the Fas-FADD, Fas-Daxx, TRAIL-FADD, and TNFR1-TRADD apoptotic pathways were all activated, collectively facilitating host cell apoptosis. The pro-apoptotic effects of these pathways were ranked in descending order, as follows: Fas signaling pathway > TNFR1 signaling pathway > TRAIL signaling pathway.

The results presented in this study indicate that FOXO1 has a tumor suppressor function, while FADD has a tumor-promoting function in OS following anticancer drug treatment. The experimental approach used in this investigation also indicates that FADD antagonizes the effect of FOXO1 on p21 expression in OS.

This study is the first to demonstrate the potent anti-melanoma effect of atranorin. This demonstrates the natural compounds' effects on cell proliferation, cell cycle progression, and the suppression of metastasis. These findings emphasize the potential of atranorin as a novel natural compound for use in adjunctive or targeted melanoma therapy, and highlight the need for further preclinical and clinical evaluation.

FEAPs exerts anticancer effects in MCF-7 breast cancer cells by modulating multiple signalling pathways and likely promoting caspase mediated apoptosis, supporting its traditional use as an anticancer remedy.

MBD4 downregulation significantly impaired carboplatin or etoposide efficacy in vitro and in vivo, respectively. In the present study, our findings indicate that depletion or mutation of MBD4 interferes with the activation of the cell cycle and apoptosis via epigenetic regulation, thereby reducing drug susceptibility. It provides new insights into the role in RB chemoresistance of MBD4 as an epigenetic regulator, which might fuel the development of new RB-targeted strategies.

This is the first study defining the function of canine RIPK3 and potentially immunostimulatory, non-lytic, cell death in canine cells. This form of cell death can be further developed to ignite immunity against virus infections and cancer.

Notably, one SRE located within the promoter region of the OBI1 gene is present in 45% of OSCC samples...Furthermore, we found that the frequently amplified region 11q13 in HNSCC is prone to large-scale somatic SVs, affecting the expression of ANO1, FADD, and CTTN, thereby confirming the association of SVs in this region with OSCC development. Our study provides novel insights into the role of somatic SVs in OSCC, especially with respect to SREs and large-scale SVs in critical genomic regions, thereby enhancing our comprehension of the molecular pathogenesis of OSCC.

Significantly, our investigation presents an approach for addressing challenges in NPs development and opening up new opportunities for drug discovery. Our findings demonstrate the utility of FBTR in exploring the function of NPs, revealing the target, and advancing drug optimization for stronger clinical translation.

Eliminating FADD, the adaptor protein that promotes caspase-8 oligomerization, prevented this perinatal lethality. Collectively, our results suggest that cFLIP forms heterodimers with caspase-8 D387A to promote apoptosis in some contexts, while limiting the activity of caspase-8 D387A homodimers in others.