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    BIOMARKER:

    FADD overexpression

    i
    Other names: FADD, GIG3, MORT1, Fas (TNFRSF6)-associated via death domain
    Entrez ID:
    8772
    Related biomarkers:
    Expression
    CNA
    7ms
    GZ17-6.02 kills PDX isolates of uveal melanoma. (PubMed, Oncotarget)
    GZ17-6.02 interacted with doxorubicin or ERBB family inhibitors to significantly enhance tumor cell killing which was associated with greater levels of autophagosome formation and autophagic flux...The components of GZ17-6.02 were detected in tumors using a syngeneic tumor model. Our data support future testing GZ17-6.02 in uveal melanoma as a single agent, in combination with ERBB family inhibitors, in combination with cytotoxic drugs, or with an anti-PD1 immunotherapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • BAP1 (BRCA1 Associated Protein 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • FADD (Fas associated via death domain) • FAS (Fas cell surface death receptor) • ATG5 (Autophagy Related 5) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) • BECN1 (Beclin 1)
    |
    PD-L1 expression • ATM overexpression • ATM expression • FADD overexpression
    |
    Gilotrif (afatinib) • Nerlynx (neratinib) • doxorubicin hydrochloride • GZ17-6.02
    8ms
    FADD amplification is associated with CD8+ T-cell exclusion and malignant progression in HNSCC. (PubMed, Oral Dis)
    Our preliminary investigation has discovered the association between FADD expression and the immunosuppressive microenvironment in HNSCC. Due to the high frequent amplification of the chromosomal region 11q13.3, where FADD is located, targeting FADD holds promise for improving the immune-inactive state of tumors, subsequently inhibiting HNSCC tumor progression.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD276 (CD276 Molecule) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • FADD (Fas associated via death domain) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1)
    |
    CD8 expression • FADD amplification • FADD overexpression
    1year
    Inhibition of murine colorectal cancer metastasis by targeting M2-TAM through STAT3/NF-kB/AKT signaling using macrophage 1-derived extracellular vesicles loaded with oxaliplatin, retinoic acid, and Libidibia ferrea. (PubMed, Biomed Pharmacother)
    Furthermore, malignant cells showed overexpression of FADD, APAF-1, caspase-3, and E-cadherin, and decreased expression of MDR1, survivin, vimentin, and PD-L1 after treatment with systems of M1EVs. The study shows that EVs from M1 antitumor macrophages can transport drugs and enhance their immunomodulatory and antitumor activity by modulating pathways associated with cell proliferation, migration, survival, and drug resistance.
    Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CDH1 (Cadherin 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • BIRC5 (Baculoviral IAP repeat containing 5) • CD163 (CD163 Molecule) • FADD (Fas associated via death domain) • IL10 (Interleukin 10) • CASP3 (Caspase 3) • VIM (Vimentin) • CCL2 (Chemokine (C-C motif) ligand 2) • CD68 (CD68 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • CCL22 (C-C Motif Chemokine Ligand 22) • APAF1 (Apoptotic peptidase activating factor 1)
    |
    BIRC5 expression • CDH1 expression • VIM expression • FADD overexpression
    |
    oxaliplatin
    over1year
    Upregulated FADD is associated with poor prognosis, immune exhaustion, tumor malignancy, and immunotherapy resistance in patients with lung adenocarcinoma. (PubMed, Front Oncol)
    In addition, FADD can be an efficient indicator for assessing sensitivity to chemotherapy and immunotherapy. Therefore, FADD has the potential to serve as a new target for precision medicine and targeted therapy for LUAD.
    Journal • IO biomarker
    |
    TP53 (Tumor protein P53) • FADD (Fas associated via death domain)
    |
    TP53 mutation • FADD overexpression
    over1year
    Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma. (PubMed, Virchows Arch)
    Further validation demonstrated that overexpression of FADD was positively correlated with the infiltration of Foxp3 in PSCC (p=0.0142). It is the first time to show that overexpression of FADD is an adjunct biomarker with poor prognosis in PSCC and could also serve as a tumor immune environment regulator.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • FADD (Fas associated via death domain) • FOXP3 (Forkhead Box P3)
    |
    PD-L1 expression • FADD overexpression • FOXP3 expression
    2years
    Expression of concern: Overexpression of FADD and Caspase-8 inhibits proliferation and promotes apoptosis of human glioblastoma cells. [Biomedicine & Pharmacotherapy 93 (2017) 1-7]. (PubMed, Biomed Pharmacother)
    No abstract available
    Journal
    |
    FADD (Fas associated via death domain) • CASP8 (Caspase 8)
    |
    FADD overexpression
    3years
    Turning immunologically cold tumors into hot ones by activating hepatoma-intrinsic FADD/NF-ΚB/CCL5 pathway (IDDF 2021)
    As we showed that FADD was positively correlated with CD8+T cells in HCC patients, our data pinpointed that FADD controls TIL abundance in HCC. Conclusions Our findings reveal an underlying mechanism of TIL accumulation in HCC, which provides a novel strategy of FADD activation in turning immunologically cold tumors into hot ones for better prognosis and immunotherapeutic responses.
    IO biomarker
    |
    CD8 (cluster of differentiation 8) • FADD (Fas associated via death domain)
    |
    FADD overexpression