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    BIOMARKER:

    FADD amplification

    i
    Other names: FADD, GIG3, MORT1, Fas (TNFRSF6)-associated via death domain
    Entrez ID:
    8772
    Related biomarkers:
    Expression
    CNA
    7ms
    FADD amplification is associated with CD8+ T-cell exclusion and malignant progression in HNSCC. (PubMed, Oral Dis)
    Our preliminary investigation has discovered the association between FADD expression and the immunosuppressive microenvironment in HNSCC. Due to the high frequent amplification of the chromosomal region 11q13.3, where FADD is located, targeting FADD holds promise for improving the immune-inactive state of tumors, subsequently inhibiting HNSCC tumor progression.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD276 (CD276 Molecule) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • FADD (Fas associated via death domain) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1)
    |
    CD8 expression • FADD amplification • FADD overexpression