FABP7 (Fatty Acid Binding Protein 7)

Therapeutic strategies targeting metabolic vulnerabilities-including SSP blockade, cholesterol homeostasis disruption, and ferroptosis induction-show synergistic effects with conventional agents like temozolomide. This review highlights the intertwined metabolic circuits in GBM and explores their translational potential as targets for precision therapy.

To summarize, this integrative model identified a novel methylation-based risk classifier/molecular subtype for BRCA, highlighting FABP7 and CLIC6 as a key prognostic biomarker with potential utility for risk stratification for strategic treatment. These findings require further validation through wet-lab experiments and prospective clinical studies to support clinical translation.

Furthermore, FABP7 silencing reduced stemness capacity, as evidenced by diminished sphere-forming ability. Mechanistically, downregulation of FABP7 led to inhibition of the Wnt/β-catenin signaling pathway. This study demonstrates that FABP7 can promote cell migration and stemness in endometrial cancer by activating the Wnt/β-catenin pathway, supporting FABP7 as a potential therapeutic target for the clinical management of endometrial cancer.

AAV-mediated expression of APRIL by cortical neuron counteracted microglial recruitment and demyelination in the splenium of CPZ-treated mice. Our multi-omics integration analysis nominated several pathways, including Fabp7-linked astrocytic lipid metabolism, to elucidate APRIL's mechanism of action. Together, these findings provide a framework for the mechanistic dissection of APRIL's therapeutic potential and further translational evaluation in CNS pathologies characterised by acute neuro-inflammatory responses.

The findings of this study suggest that FABP7 and MAOB expression in serum may serve as diagnostic markers for meningiomas. However, additional studies with larger cohorts are necessary to validate these results.

We found that the FABP7-PKC-pGAP43 axis is key to GBM TM formation, with TMs serving as networks for efficient long-distance cell migration. Our results indicate that TM formation can be mitigated by FABP7 inhibition with the potential of improving clinical outcomes in GBM patients.

Our findings reveal a novel mechanism involving FABP7-mediated LD in macrophages that contributes to liver PMN formation and metastasis. This suggests that targeting FABP7 may offer prognostic and therapeutic potential in addressing liver metastasis.

However, challenges such as insufficient target specificity, cross-cancer heterogeneity, and normal tissue toxicity remain. Future studies should integrate multi-omics and single-cell technologies to elucidate cell-specific mechanisms and develop precise combination therapies for clinical translation.

This study is an example of the potential of ML in precision oncology through enhanced biomarker discovery and prediction of metastasis. The incorporation of ML models with biological visualization software gives insights into targeted therapy approaches in breast cancer.

This study identified distinct LMF-related molecular clusters in HR+ breast cancer with unique prognostic and immune characteristics. The LMF_index shows potential as a prognostic biomarker and a guide for immunotherapy strategies in HR+ breast cancer.

In vitro, PCM@TMA-lip inhibited tumor cell malignancy and suppressed the growth of 3D spheroids. In vivo, it suppressed tumor progression, reduced Ki67+ proliferation, increased TUNEL+ apoptosis, and prolonged survival in GBM-bearing mice, highlighting its potential as an effective strategy to improve GBM chemotherapy.

We observed transcriptional shifts toward the invasive MITFLow/AXLHigh phenotype, with upregulation of transforming growth factor-beta (TGF-β) receptor mRNAs. In conclusion, FABP7 may help balancing lipid saturation and maintain the proliferative state of melanomas, mitigating invasiveness and metastatic formation.