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    BIOMARKER:

    FABP7 overexpression

    i
    Other names: FABP7, Fatty Acid Binding Protein 7, B-FABP, BLBP, Brain-Type Fatty Acid-Binding Protein, Fatty Acid-Binding Protein, Brain, Brain Lipid-Binding Protein, FABPB, MRG, Mammary-Derived Growth Inhibitor-Related, Mammary-Derived Growth Inhibitor Related, Fatty Acid Binding Protein 7, Brain, Hypothetical Protein DKFZp547J2313, Fatty Acid-Binding Protein 7, Brain Lipid Binding Protein
    Entrez ID:
    2173
    over3years
    Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation. (PubMed, FEBS J)
    Interestingly, these OA-boosted functions were abrogated in FABP7 knockout cells and mutant FABP7-overexpressing cells. Thus, our findings suggest that FABP7-OA intracellular interaction may modulate nLD formation and the epigenetic status thereby enhancing transcription of proliferation-regulating genes, ultimately driving tumor cell proliferation.
    Journal
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    FABP7 (Fatty Acid Binding Protein 7)
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    FABP7 overexpression