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    GENE:

    FABP6 (Fatty Acid Binding Protein 6)

    i
    Other names: FABP6, Fatty Acid Binding Protein 6, I-BABP, I-15P, ILLBP, ILBP, Gastrotropin, I-BALB, I-BAP, ILBP3, Fatty Acid Binding Protein 6, Ileal, Ileal Bile Acid Binding Protein, Illeal Lipid-Binding Protein, Ileal Lipid-Binding Protein, Intestinal 15 KDa Protein, GT, Intestinal Bile Acid-Binding Protein, Fatty Acid-Binding Protein 6
    Associations

    News

    Trials
    2ms
    Highly Expressed Fatty Acid-Binding Protein 6 Mediates Lipid Metabolism Remodeling in Tumor Cells via Intracellular Bile Acid Transport to Promote Pancreatic Cancer Metastasis. (PubMed, Mol Carcinog)
    FABP6 overexpression promoted lipid metabolism reprogramming by enhancing intracellular bile acid transport to activate NR1H2/3, thereby accelerating PC progression. These findings offered new insights into PC molecular mechanisms and potential therapeutic targets.
    Journal
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    FABP6 (Fatty Acid Binding Protein 6)
    7ms
    Fatty acid-binding proteins in cancers. (PubMed, Int J Surg)
    However, challenges such as insufficient target specificity, cross-cancer heterogeneity, and normal tissue toxicity remain. Future studies should integrate multi-omics and single-cell technologies to elucidate cell-specific mechanisms and develop precise combination therapies for clinical translation.
    Journal
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    CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • FABP7 (Fatty Acid Binding Protein 7) • FABP1 (Fatty Acid Binding Protein 1) • FABP4 (Fatty Acid Binding Protein 4) • FABP5 (Fatty Acid Binding Protein 5) • FABP6 (Fatty Acid Binding Protein 6)
    9ms
    The role of bile acid metabolism-related genes in prognosis assessment of hepatocellular carcinoma and identification of NPC1 as a biomarker. (PubMed, Front Endocrinol (Lausanne))
    In conclusion, BAM-related genes offer a promising avenue for improving prognosis assessment in HCC patients. Our findings highlight the potential of NPC1 as a valuable tool for risk stratification and personalized treatment strategies in HCC patients.
    Journal
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    FABP6 (Fatty Acid Binding Protein 6)
    9ms
    A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma. (PubMed, Adv Sci (Weinh))
    FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity in ccRCC cells. Thus, the study has identified potential targets for drug design and diagnosis and discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC.
    Journal
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    EPAS1 (Endothelial PAS domain protein 1) • FABP5 (Fatty Acid Binding Protein 5) • FABP6 (Fatty Acid Binding Protein 6) • LPCAT1 (Lysophosphatidylcholine Acyltransferase 1)
    11ms
    Identification of Deregulated miRNAs and mRNAs Involved in Tumorigenesis and Detection of Glioblastoma Patients Applying Next-Generation RNA Sequencing. (PubMed, Pharmaceuticals (Basel))
    Based on the PPI network, a functional enrichment analysis of the target proteins was also carried out. (4) We identified an miRNA panel and several deregulated mRNAs that could play an important role in tumor development and distinguish GBM patients from healthy controls with high sensitivity and specificity using total RNA isolated from tissue samples.
    Journal
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    MIR21 (MicroRNA 21) • AURKB (Aurora Kinase B) • MIR490 (MicroRNA 490) • MYBL2 (MYB Proto-Oncogene Like 2) • CDC45 (Cell Division Cycle 45) • E2F2 (E2F Transcription Factor 2) • FABP6 (Fatty Acid Binding Protein 6) • HOXC10 (Homeobox C10) • MIR10B (MicroRNA 10b) • MIR383 (MicroRNA 383)
    1year
    Signature of immune-related metabolic genes predicts the prognosis of hepatocellular carcinoma. (PubMed, Front Immunol)
    We observed variations in prognosis among different risk groups, accompanied by distinct immune and metabolic characteristics. Therefore, our model provides an original evaluation index for personalized clinical treatment strategies targeting HCC patients.
    Journal
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    FABP6 (Fatty Acid Binding Protein 6)
    over1year
    REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway. (PubMed, Front Biosci (Landmark Ed))
    REST positively regulates autophagy and negatively affects the Akt/mTOR signaling pathway in GC cells in a FABP6-dependent manner, providing valuable insights into regulatory networks involving FABP6 and REST.
    Journal
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    FABP6 (Fatty Acid Binding Protein 6)
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    LY294002 • MG132
    almost2years
    Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics. (PubMed, Environ Int)
    This work shows how single cell transcriptomics can be applied to selectively study the in vitro effects of endocrine disrupters and their interaction with different hormonal contexts.
    Journal
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    ER (Estrogen receptor) • AR (Androgen receptor) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • APOA1 (Apolipoprotein A-I) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • FABP1 (Fatty Acid Binding Protein 1) • FABP6 (Fatty Acid Binding Protein 6)
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    PGR expression
    almost2years
    A novel gene signature related to fatty acid metabolism predicts prognosis, immune landscape, and drug sensitivity in early-stage lung squamous cell carcinoma. (PubMed, Transl Cancer Res)
    The FAMRGs-based signature demonstrated superior sensitivity in predicting the prognosis of early-stage LUSC. Detecting FAMRGs may provide predictive targets for the development of clinical treatment strategies.
    Journal • Gene Signature
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    CYP2R1 (Cytochrome P450 Family 2 Subfamily R Member 1) • FABP6 (Fatty Acid Binding Protein 6) • FADS2 (Fatty Acid Desaturase 2)
    2years
    FABP6 serves as a new therapeutic target in esophageal tumor. (PubMed, Aging (Albany NY))
    Cellular communication analysis identified increased interactions between FABP6+ tumor cells and T cells, with the involvement of the MIF-related pathway and the CD74-CD44 interaction. This study provides insights into the cellular landscape and immune interactions within esophageal tumors, contributing to a better understanding of tumor heterogeneity and potential therapeutic targets.
    Journal
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    CD8 (cluster of differentiation 8) • CD74 (CD74 Molecule) • FABP6 (Fatty Acid Binding Protein 6)
    over2years
    Comprehensive Analysis of the Roles of Fatty Acid Transport Related Proteins in Clear Cell Renal Cell Carcinoma. (PubMed, Prostaglandins Other Lipid Mediat)
    Only a few FATRP genes are upregulated in ccRCC tumor tissue, and positively correlate with tumor progression and poor prognosis. The accuracy of a single gene of these FATRP genes as predictors of progression and prognosis of ccRCC is limited. The performance of the novel prediction model proposed by this study was much better than that of any single gene.
    Journal
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    FABP7 (Fatty Acid Binding Protein 7) • FABP1 (Fatty Acid Binding Protein 1) • FABP5 (Fatty Acid Binding Protein 5) • FABP6 (Fatty Acid Binding Protein 6)
    almost3years
    Kruppel-like factor 5 enhances proliferation, lipid droplet formation and oxaliplatin resistance in colorectal cancer by promoting fatty acid binding protein 6 transcription. (PubMed, Anticancer Drugs)
    KLF5 downregulation restrained CRC tumor growth and OXA resistance in vivo. In conclusion, KLF5 knockdown reduced FABP6 transcription to protect against proliferation, lipid droplet formation and OXA resistance in CRC.
    Journal
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    FABP6 (Fatty Acid Binding Protein 6)
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    oxaliplatin