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    BIOMARKER:

    EWSR1-TFCP2 fusion

    i
    Other names: EWSR1, EWS RNA Binding Protein 1, Ewing Sarcoma Breakpoint Region 1, RNA-Binding Protein EWS, EWS, Ewings Sarcoma EWS-Fli1 (Type 1) Oncogene, Ewing Sarcoma Breakpoint Region 1 Protein, EWS RNA-Binding Protein Variant 6, EWS Oncogene, BK984G1.4, EWS-FLI1, TFCP2, Transcription factor CP2, Alpha-globin transcription factor CP2, SAA3 enhancer factor, LSF1D, TFCP2C
    Entrez ID:
    2130; 7024
    Related biomarkers:
    Mutation
    Fusion
    4ms
    Clinicopathological study of epithelioid and spindle cell rhabdomysarcoma with EWSR1/FUS-TFCP2 fusion (PubMed, Zhonghua Bing Li Xue Za Zhi)
    Their genetic hallmark is the presence of EWSR1/FUS-TFCP2 fusions. Familiarity with its clinicopathological characteristics is helpful in avoiding misdiagnoses.
    Retrospective data • Journal
    |
    ALK (Anaplastic lymphoma kinase) • EWSR1 (EWS RNA Binding Protein 1) • FUS (FUS RNA Binding Protein) • TFCP2 (Transcription Factor CP2) • MYOD1 (Myogenic Differentiation 1) • YOD1 (YOD1 Deubiquitinase)
    |
    EWSR1-TFCP2 fusion
    4ms
    Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions. (PubMed, Nat Commun)
    In two patients, sarcoma was preceded by benign lesions carrying FUS-TFCP2, indicating stepwise sarcomagenesis. This study illustrates the potential of linking precision oncology with preclinical research to gain insight into the classification, pathogenesis, and therapeutic vulnerabilities of rare cancers.
    Journal
    |
    MTAP (Methylthioadenosine Phosphorylase) • EWSR1 (EWS RNA Binding Protein 1) • FUS (FUS RNA Binding Protein) • TFCP2 (Transcription Factor CP2)
    |
    EWSR1-TFCP2 fusion
    over1year
    Molecular profile of head and neck rhabdomyosarcomas: A systematic review and meta-analysis. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol)
    The genotypic profile of histologic variants of HNRMS is widely variable, and MYOD1 mutation could be a potential prognostic factor, but more studies are required to establish this.
    Retrospective data • Review • Journal
    |
    EWSR1 (EWS RNA Binding Protein 1) • FUS (FUS RNA Binding Protein) • TFCP2 (Transcription Factor CP2) • MYOD1 (Myogenic Differentiation 1)
    |
    EWSR1-TFCP2 fusion