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    BIOMARKER:

    ETV5 overexpression

    i
    Other names: ETV5, ETS Variant Transcription Factor 5, ETS Variant 5, ETS Translocation Variant 5, Ets-Related Protein ERM, Ets-Related Molecule, ERM, Ets Variant Gene 5 (Ets-Related Molecule)
    Entrez ID:
    2119
    Related biomarkers:
    Mutation
    3ms
    ETV5 Silencing Produces Mesenchymal to Epithelial Transition in INS-1 (832/13) Cell Line. (PubMed, Horm Metab Res)
    In addition, TGFβ1 and TGFβ3 were downregulated in the absence of ETV5. ETV5 silencing induces epithelial phenotype by downregulating TGFβ1 and TGFβ3 in INS-1 (832/13) cell line.
    Preclinical • Journal
    |
    CDH1 (Cadherin 1) • TGFB1 (Transforming Growth Factor Beta 1) • ETV5 (ETS Variant Transcription Factor 5)
    |
    ETV5 overexpression
    8ms
    ETV5 transcriptionally activates TGFβ1 and promotes cancer cell invasion and migration of NSCLC. (PubMed, J Mol Histol)
    Elevated ETV5 expression promotes NSCLC cell invasion and migration via transcriptional activates of TGFβ1. Therefore, ETV5/TGFβ signaling may serve as a therapeutic target for NSCLS patients.
    Journal
    |
    TGFB1 (Transforming Growth Factor Beta 1) • ETV5 (ETS Variant Transcription Factor 5)
    |
    ETV5 overexpression
    almost2years
    ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2. (PubMed, Int J Med Sci)
    ETV5 promoted metastasis of ESCC by activating MMPs through augmenting the transcription of SKA1 and TRPV2. ETV5 was likely to be a novel oncogene and therapeutic target in ESCC.
    Journal
    |
    ETV5 (ETS Variant Transcription Factor 5) • TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2)
    |
    ETV5 overexpression
    over2years
    Biological and prognostic value of ETV5 in high-grade serous ovarian cancer. (PubMed, J Ovarian Res)
    ETV5 has a carcinogenic effect in HGSOC and can be used as a clinically effective biomarker to determine the prognosis of HGSOC patients.
    Journal
    |
    ETV5 (ETS Variant Transcription Factor 5)
    |
    ETV5 overexpression
    almost3years
    LncRNA HCG18 promotes cell multiplication and metastasis by miR-148b/ETV5 regulation in osteosarcoma. (PubMed, Am J Transl Res)
    LncRNA HCG18 acted as a sponge of miR-148b and played an oncogenic role in osteosarcoma, providing therapeutic targets for osteosarcoma.
    Journal
    |
    ETV5 (ETS Variant Transcription Factor 5)
    |
    ETV5 overexpression
    3years
    The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progression. (PubMed, Cell Death Dis)
    Moreover, ETV5 changed drug-sensitivity to palbociclib and dinaciclib. Therefore, therapeutic regimens targeting ETV5 may be promising in improving the efficacy of target-CDK treatment in CRC.
    Journal
    |
    CDK6 (Cyclin-dependent kinase 6) • ETV5 (ETS Variant Transcription Factor 5)
    |
    ETV5 overexpression
    |
    Ibrance (palbociclib) • dinaciclib (MK-7965)