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    BIOMARKER:

    ETV1 overexpression

    i
    Other names: ETV1, ETS Variant Transcription Factor 1, ER81, ETS Translocation Variant 1, Ets-Related Protein 81, Ets Variant Gene 1, ETS Variant 1
    Entrez ID:
    2115
    Related biomarkers:
    Mutation
    over2years
    Immunohistochemical markers as predictors of prognosis in multifocal prostate cancer. (PubMed, Virchows Arch)
    In conclusion, our results indicate that UF and MF PCa have relevant and consistent molecular differences. The analysis of an immunohistochemical panel, composed by PTEN, SPOP, SLC45A3, ETV1 and ERG, could be useful to predict outcome in MF cases.
    Journal
    |
    PTEN (Phosphatase and tensin homolog) • SPOP (Speckle Type BTB/POZ Protein) • ETV1 (ETS Variant Transcription Factor 1) • SLC45A3 (Solute Carrier Family 45 Member 3)
    |
    PTEN expression • PTEN overexpression • ERG overexpression • ETV1 overexpression
    over2years
    Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression. (PubMed, Growth Factors)
    ETV1 overexpression partially antagonized the suppression of silencing MAFG-AS1 on PC cells. ETV1-induced MAFG-AS1 stabilized the ETV1 expression by recruiting IGF2BP2 and promoted PC cell migration, invasion, proliferation, and EMT.
    Journal
    |
    ETV1 (ETS Variant Transcription Factor 1) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2)
    |
    ETV1 overexpression
    almost3years
    Development and characterization of an ETV1 rabbit monoclonal antibody for the immunohistochemical detection of ETV1 expression in cancer tissue specimens. (PubMed, J Immunol Methods)
    The selective detection of ETV1 by the 29E4 mAb in immunoblots, IFA, and IHC assays using human prostate tissue specimens reveals a potential utility for the diagnosis, the prognosis of prostate adenocarcinoma and other cancers, and the stratification of patients for treatment by ETV1 inhibitors.
    Preclinical • Journal
    |
    ETV1 (ETS Variant Transcription Factor 1)
    |
    ETV1 overexpression
    over3years
    HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET. (PubMed, J Exp Clin Cancer Res)
    This study uncovers functional and prognostic roles for ETV1 in HCC and exposes a positive feedback loop of HGF-ERK1/2-ETV1-c-MET. Targeting this pathway may provide a potential therapeutic intervention for ETV1-overexpressing HCC.
    Journal
    |
    MET (MET proto-oncogene, receptor tyrosine kinase) • ETV1 (ETS Variant Transcription Factor 1) • TYK2 (Tyrosine Kinase 2) • PTK2 (Protein Tyrosine Kinase 2)
    |
    ETV1 overexpression
    |
    Tabrecta (capmatinib) • Fakzynja (defactinib)
    almost5years
    Glucose-Regulated Protein 94 Mediates the Proliferation and Metastasis through the Regulation of ETV1 and MAPK Pathway in Colorectal Cancer. (PubMed, Int J Med Sci)
    Our results indicated that silencing GRP94 repressed the ability of EMT process, cancer cell proliferation, metastasis, and CRC tumorigenesis. Therefore, GRP94 may play an important role in CRC by regulating ETV1 and MAPK pathway.
    Journal
    |
    ETV1 (ETS Variant Transcription Factor 1) • VIM (Vimentin)
    |
    ETV1 overexpression