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    BIOMARKER:

    ETV1 E462Q

    i
    Other names: ETV1, ETS Variant Transcription Factor 1, ER81, ETS Translocation Variant 1, Ets-Related Protein 81, Ets Variant Gene 1, ETS Variant 1
    Entrez ID:
    2115
    Related biomarkers:
    Expression
    Mutation
    over2years
    Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors. (PubMed, Ann Transl Med)
    ETV1 p.E462Q and p.P159S mutations were also resistant to gefitinib and osimertinib after introduction into H358 cells. Novel ETV1 p.E462Q and p.P159S mutations were found in the SCLC tissues of TKIs-resistant LUAD patients, providing a new understanding of ETV1 involvement in acquired resistance to EGFR-TKIs via SCLC transformation.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • ETV1 (ETS Variant Transcription Factor 1)
    |
    EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR exon 21 mutation • ETV1 E462Q • ETV1 P159S • ETV1 E462Q + ETV1 P159S
    |
    Tagrisso (osimertinib) • gefitinib