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GENE:

ETS1 (ETS Proto-Oncogene 1)

News alerts, weekly reports and conference planners

CX3CR1 identifies a potent effector CD8+ T cell subset associated with anti-PD-1 therapeutic efficacy in colorectal cancer. (PubMed, Front Immunol)

This study characterizes CX3CR1+CD8+T cells as a key effector subset predicting prognosis and immunotherapy response in colorectal cancer. These insights not only support their use as a clinically meaningful biomarker but also highlight the regulatory network orchestrated by ETS1 and PRDM1 as a promising avenue for overcoming immune resistance.

8 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • ETS1 (ETS Proto-Oncogene 1) • PRDM1 (PR/SET Domain 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • PRF1 (Perforin 1) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1)

MSI-H/dMMR

10d

Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP3/miR-760/PUM1 axis. (PubMed, Oncogene)

These findings establish for the first time that circPTBP3 functions as a pivotal mediator of F. nucleatum 's oncogenicity, and reveal a novel F. nucleatum-circPTBP3-miR-760-PUM1 regulatory axis that promotes CRC progression. CircPTBP3 may serve as a potential biomarker and therapeutic target in F. nucleatum-associated colorectal carcinogenesis.

10 days ago

Journal

ETS1 (ETS Proto-Oncogene 1) • MIR760 (MicroRNA 760) • PUM1 (Pumilio RNA Binding Family Member 1)

21d

Gene expression and metadata based identification of key genes for lung cancer, COPD, and IPF using machine learning and statistical models. (PubMed, PLoS One)

The outcomes present a solid framework for subsequent research and therapy strategies for LC, COPD, and IPF. The potential drug compounds targeting the identified key genes are proposed, offering new avenues for the development of treatment.

21 days ago

Journal

MSH2 (MutS Homolog 2) • ETS1 (ETS Proto-Oncogene 1) • PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1)

24d

Development and function of specified thymic iNKT1 cells critically depend on an Ets1-Tbet transcription factor axis. (PubMed, J Immunol)

In peripheral tissues, elevated Tbet expression failed to overcome the requirement for Ets1 in activation-induced interferon γ-production but instead drove increased cytotoxic effector protein expression. Our findings establish Ets1 as a central regulator of iNKT1 cell homeostasis, enforcing a tissue-resident identity in the thymus and supporting context-appropriate effector function.

24 days ago

Journal

CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TGFB1 (Transforming Growth Factor Beta 1) • ETS1 (ETS Proto-Oncogene 1) • ITGAE (Integrin Subunit Alpha E)

25d

ETS1-driven transcriptional activation of USP43 promotes lenvatinib resistance in hepatocellular carcinoma through MYH9 stabilization and AKT/BAD signaling. (PubMed, Mol Cancer Res)

This stabilizes the MYH9 protein by preventing its degradation through the ubiquitin-proteasome pathway and further activates the AKT/BAD signaling axis, ultimately suppressing apoptosis and conferring lenvatinib resistance. Implications: Targeting the ETS1/USP43/MYH9 axis presents a promising therapeutic strategy to overcome lenvatinib resistance in HCC.

25 days ago

Journal

ETS1 (ETS Proto-Oncogene 1) • MYH9 (Myosin Heavy Chain 9)

Lenvima (lenvatinib)

29d

Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells. (PubMed, J Inflamm Res)

Furthermore, siRNA targeting melatonin receptor 2 (MT2) attenuated melatonin-induced SIRT1 upregulation, ETS1 deacetylation, and pyroptosis inhibition. Our findings indicate that melatonin alleviates LPS-induced pyroptosis in alveolar epithelial cells through the MT2/SIRT1/ETS1/NLRP3 signaling pathway.

29 days ago

Journal

ETS1 (ETS Proto-Oncogene 1) • NLRP3 (NLR Family Pyrin Domain Containing 3) • SIRT1 (Sirtuin 1)

Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis. (PubMed, Front Cell Infect Microbiol)

To explore potential therapeutic interventions, we performed small-molecule drug prediction and molecular docking for hub genes revealed: Simvastatin: Linked to CCL20, NFKBIA, and ICAM1. Atorvastatin: Associated with CDKN1A, ICAM1, and TNF. TPCA-1: Targeting JAK1. These findings provide a theoretical foundation for further investigation into the molecular mechanisms underlying H. pylori-related diseases.

1 month ago

Journal

BRCA1 (Breast cancer 1, early onset) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • BIRC3 (Baculoviral IAP repeat containing 3) • JAK1 (Janus Kinase 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • CCL20 (C-C Motif Chemokine Ligand 20) • ICAM1 (Intercellular adhesion molecule 1) • IRF1 (Interferon Regulatory Factor 1) • ITGAM (Integrin, alpha M) • SPI1 (Spi-1 Proto-Oncogene) • ETS1 (ETS Proto-Oncogene 1) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • NFKBIA (NFKB Inhibitor Alpha 2) • NFKBIE (NFKB Inhibitor Epsilon) • TRAF1 (TNF Receptor Associated Factor 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • E2F1 (E2F transcription factor 1) • EGR1 (Early Growth Response 1) • HSF1 (Heat Shock Transcription Factor 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)

simvastatin • atorvastatin

2ms

ETS1 potentiates pancreatic Pyroptosis in mice with acute pancreatitis by regulating the NKIRAS1/NF-κB Axis. (PubMed, Int Immunopharmacol)

This study reveals that ETS1 transcriptionally suppresses NKIRAS1, activating NF-κB signaling and promoting pyroptosis and pancreatic injury in AP. Targeting ETS1 may represent a promising therapeutic strategy.

2 months ago

Preclinical • Journal

ETS1 (ETS Proto-Oncogene 1)

ONCT-216 • Bay11-7082

2ms

Epigenetic Silencing of Primary Cilia Genes by PRAME and ETS2 in Melanoma Cells. (PubMed, J Cell Physiol)

Together, these findings suggest that PRAME and ETS2 cooperatively suppress ciliogenesis in melanoma cells, proposing a previously unrecognized epigenetic mechanism of ciliary loss. This mechanism broadens our understanding of melanoma progression and highlights the role of the PRAME-ETS2-HDAC1 axis in regulating ciliogenesis.

2 months ago

Journal

PRAME (Preferentially Expressed Antigen In Melanoma) • ETS1 (ETS Proto-Oncogene 1) • HDAC1 (Histone Deacetylase 1)

2ms

Biomarkers of Common Molecular Dysregulation in Tumor Tissue and Peritumor Mucosa in Head and Neck SCC: Insights into Field Cancerization. (PubMed, Int J Mol Sci)

The identification and validation of biomarkers reflecting this continuum could enable the establishment of molecular margins-improving risk assessment, reducing local recurrence, and advancing personalized oncologic surgery in HNSCC. Standardizing definitions and sampling protocols for "normal adjacent tissue" remains essential for future translational research.

2 months ago

Review • Journal

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • MIR21 (MicroRNA 21) • ETS1 (ETS Proto-Oncogene 1) • MIR96 (MicroRNA 96) • E2F2 (E2F Transcription Factor 2) • MIR145 (MicroRNA 145)

2ms

Molecular basis of UV lesion binding and repair inhibition by ETS-family transcription factors. (PubMed, bioRxiv)

ETS-family proteins from all major classes bind CPD-containing DNA sites.Engagement of CPD by ETS proteins inhibits DNA repair in a position-dependent manner.Structure and thermodynamics of ETS binding to damaged DNA differ from undamaged substrates.

2 months ago

Journal

ETS1 (ETS Proto-Oncogene 1) • ELF1 (E74 Like ETS Transcription Factor 1)

3ms

The role of constitutive nitric-oxide synthase in regulation of IKKα after ultraviolet irradiation. (PubMed, Photochem Photobiol)

These results demonstrate that cNOS regulates IKKα at multiple levels-promoter activation, transcriptional elongation, and protein stability. This multilayered control enhances our understanding of UV-induced skin pathogenesis and supports cNOS-IKKα signaling as a potential target for therapeutic intervention in skin cancer.

3 months ago

Journal

ETS1 (ETS Proto-Oncogene 1)