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    BIOMARKER:

    ESR1 rs2228480

    i
    Other names: ESR1, Era, ESR, NR3A1, ER, ER beta
    Entrez ID:
    2099
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    The Role of Female Reproductive Hormones in the Association between Migraine and Breast Cancer: An Unanswered Question. (PubMed, Biomedicines)
    However, the possible specific mutation or polymorphism involved in this association has not yet been identified. Further studies with robust methodologies are needed to validate the protective role of Mi in BC and fully elucidate the precise nature of this causal relationship.
    Review • Journal
    |
    ER (Estrogen receptor)
    |
    ESR1 rs2228480
    over1year
    Association of ESR1 gene polymorphisms with the susceptibility to Hepatitis B virus infection and the clinical outcomes. (PubMed, J Med Virol)
    Haplotype C-G-G was associated with significantly increased risk of HBV persistence (OR=1.37, 95%CI=1.08-1.73), while it was opposite for C-A-G and T-G-G (OR=0.41, 95%CI=0.27-0.62; OR=0.53, 95%CI=0.32-0.85, respectively). These results imply that combinations of these ESR1 polymorphisms may be valuable for the prediction of HBV persistence.
    Clinical data • Journal
    |
    ER (Estrogen receptor)
    |
    ER rs2234693 • ESR1 rs2228480
    over2years
    GENOTYPE ANALYSIS OF ESR1; ESR2 AND CYP19A1 GENES OF PAKISTANI BREAST CANCER PATIENTS (EACR 2022)
    Conclusion ESR1 and CYP19A1 alleles and genotypes, and specific 3-locus ESR1 haplotypes are related with increased breast cancer susceptibility in Pakistani women. However, ESR2 variant and specific 1-locus ESR1 haplotype have a protective effect.
    Clinical
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
    |
    HER-2 positive • ER positive • HER-2 negative • ESR1 rs2228480