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    DRUG:

    eritoran (E5564)

    i
    Other names: E5564, B-1287
    Associations

    News

    Trials
    Company:
    Eisai
    Drug class:
    TLR4 antagonist, Endotoxin inhibitor
    Related drugs:
    Associations

    News

    Trials
    9ms
    REMAP-CAP: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (clinicaltrials.gov)
    P3, N=20000, Recruiting, UMC Utrecht | N=10000 --> 20000
    Enrollment change
    |
    imatinib • hydroxychloroquine • simvastatin • Actemra IV (tocilizumab) • Kevzara (sarilumab) • Kineret (anakinra) • captopril • eritoran (E5564)
    over1year
    Quality of life (QoL) and toxicity in patients (pts) with hormone receptor-positive, HER2-negative early breast cancer (HR+, HER2– eBC) treated with adjuvant (adj) endocrine therapy (ET) in the CANcer TOxicities (CANTO) study (ESMO 2023)
    Results Of the 5564 pts who met the inclusion criteria (median age: 57 yrs), 63% were post-menopausal and 52% had stage I eBC at diagnosis...This study confirmed long-term toxicity of ET, particularly pain. Better management of symptoms and supportive interventional strategies are needed to further improve QoL in eBC.
    Clinical • HEOR
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HR positive • HER-2 negative • HR positive + HER-2 negative
    |
    eritoran (E5564)
    4years
    Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis. (PubMed, Biosci Rep)
    The array data of GSE41368, GSE43795, GSE55643, and GSE41369 were downloaded from Gene Expression Omnibus (GEO) database...miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR-455-3p, miR-744 and hub genes predicted poor OS of PDAC. An integrative bioinformatics analysis identified several hub genes that may serve as potential biomarkers or targets for early diagnosis and precision target treatment of PDAC.
    Journal
    |
    MET (MET proto-oncogene, receptor tyrosine kinase) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MIR21 (MicroRNA 21) • MIR221 (MicroRNA 221) • MIR27A (MicroRNA 27a) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • MIR135B (MicroRNA 135b)
    |
    eritoran (E5564)