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    BIOMARKER:

    ERBB3 underexpression

    i
    Other names: ERBB3, HER3, LCCS2, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
    Entrez ID:
    2065
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    2ms
    HER3: Updates and current biology function, targeted therapy and pathologic detecting methods. (PubMed, Life Sci)
    Simultaneously, numerous approaches to HER3 targeted therapy are enumerated, and the clinical detection methods for HER3 that are commonly employed in pathology are sorted and contrasted to offer physicians a range of options. We think that a better knowledge of the mechanisms underlying HER3 in tumors and the advancement of targeted HER3 therapy will contribute to an improved prognosis for cancer patients and an increase in the efficacy of anticancer therapies.
    Review • Journal
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
    |
    EGFR expression • ERBB3 expression • ERBB3 overexpression • ERBB3 mutation • ERBB3 underexpression
    over4years
    Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation. (PubMed, Onco Targets Ther)
    In vivo studies demonstrated that down-regulation of USP8 inhibited HER-3 positive tumors growth. Down-regulation of USP8 inhibits HER-3 positive GC cells proliferation in vivo and in vitro, which indicate that USP8 represents a feasible choice as a therapeutic target for HER-3 positive GC cells.
    Journal
    |
    ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
    |
    ERBB3 expression • ERBB3 overexpression • ERBB3 underexpression