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    BIOMARKER:

    ER rs2234693

    i
    Other names: ESR1, Era, ESR, NR3A1, ER, ER beta
    Entrez ID:
    2099
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    Estrogen receptor alpha (ESR1) gene polymorphism (rs2234693 and rs2046210) with breast cancer risk in pashtun population of Khyber Pakhtunkhwa. (PubMed, Mol Biol Rep)
    It is concluded that ESR1-rs2234693 is not associated with breast cancer, while rs2046210 is significantly associated with the risk of breast cancer in Khyber Pakhtunkhwa population. Further, to confirm the exact situation of ESR1 polymorphism, ESR1 existing and other SNPs need to be investigated in diverse data sets.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
    |
    ER rs2234693
    over1year
    Association between ESR1 rs2234693 single nucleotide polymorphism and uterine fibroids in Taiwanese premenopausal and postmenopausal women. (PubMed, J Health Popul Nutr)
    The TC and CC genotypes of the ESR1 rs2234693 variant may reduce susceptibility to UFs, especially in premenopausal women.
    Journal
    |
    ER (Estrogen receptor)
    |
    ER rs2234693
    over1year
    Association of ESR1 gene polymorphisms with the susceptibility to Hepatitis B virus infection and the clinical outcomes. (PubMed, J Med Virol)
    Haplotype C-G-G was associated with significantly increased risk of HBV persistence (OR=1.37, 95%CI=1.08-1.73), while it was opposite for C-A-G and T-G-G (OR=0.41, 95%CI=0.27-0.62; OR=0.53, 95%CI=0.32-0.85, respectively). These results imply that combinations of these ESR1 polymorphisms may be valuable for the prediction of HBV persistence.
    Clinical data • Journal
    |
    ER (Estrogen receptor)
    |
    ER rs2234693 • ESR1 rs2228480
    over2years
    ESR1 PvuII polymorphism: from risk factor to prognostic and predictive factor of the success of primary systemic therapy in advanced breast cancer. (PubMed, BMC Cancer)
    The ESR1 PvuII TC + CC genotypes confer poor prognosis in advanced breast cancer, but these genotypes could be regarded as a good predictor of the therapeutic effect of hormonal treatment.
    Clinical • Retrospective data • Journal
    |
    ER (Estrogen receptor)
    |
    ER rs2234693